Loss of Plasmid-Mediated Oligopeptide Transport System in Lactococci: Another Reason for Slow Milk Coagulation
Fast milk-coagulating (Fmc+) strains of lactococci are known to segregate slow milk-coagulating (Fmc−) variants, which has been attributed to loss of proteinase (Prt) activity encoded by plasmid DNA. It was found that the Fmc−phenotype could also be due to loss of a plasmid encoding an oligopeptide...
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| Veröffentlicht in: | Plasmid 1996-05, Vol.35 (3), p.145-155 |
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| creator | Yu, Weizhu Gillies, Kevin Kondo, Jeffery K. Broadbent, Jeffery R. McKay, Larry L. |
| description | Fast milk-coagulating (Fmc+) strains of lactococci are known to segregate slow milk-coagulating (Fmc−) variants, which has been attributed to loss of proteinase (Prt) activity encoded by plasmid DNA. It was found that the Fmc−phenotype could also be due to loss of a plasmid encoding an oligopeptide permease (Opp) system. InLactococcus lactissubsp.lactis(L. lactis) C2O, lactose metabolism (Lac) and Prt were linked to pJK550 and the Opp system to pJK430. InLactococcus lactissubsp.cremorisSK11, known to possess Prt on a 78-kb plasmid, DNA sequence analysis of a 7.4-kb region from the Lac plasmid, pSK11L, revealed that it possessed the Opp system. The Lac plasmid inL. lactisC2 encoded both the Prt and Opp systems. Fmc−derivatives ofL. lactisC2 were missing theprtgenes and had Opp integrated into the chromosome, possibly due to transposition events. Growth studies showed the Opp systems were functional and, in combination with Prt, produced the Fmc+phenotype. |
| doi_str_mv | 10.1006/plas.1996.0017 |
| format | Article |
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It was found that the Fmc−phenotype could also be due to loss of a plasmid encoding an oligopeptide permease (Opp) system. InLactococcus lactissubsp.lactis(L. lactis) C2O, lactose metabolism (Lac) and Prt were linked to pJK550 and the Opp system to pJK430. InLactococcus lactissubsp.cremorisSK11, known to possess Prt on a 78-kb plasmid, DNA sequence analysis of a 7.4-kb region from the Lac plasmid, pSK11L, revealed that it possessed the Opp system. The Lac plasmid inL. lactisC2 encoded both the Prt and Opp systems. Fmc−derivatives ofL. lactisC2 were missing theprtgenes and had Opp integrated into the chromosome, possibly due to transposition events. Growth studies showed the Opp systems were functional and, in combination with Prt, produced the Fmc+phenotype.</description><identifier>ISSN: 0147-619X</identifier><identifier>EISSN: 1095-9890</identifier><identifier>DOI: 10.1006/plas.1996.0017</identifier><identifier>PMID: 8812781</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ACIDE ORGANIQUE ; ACIDOS ORGANICOS ; Animals ; BACTERIA ; Bacterial Proteins - genetics ; Base Sequence ; BIOSINTESIS ; BIOSYNTHESE ; COAGULACION ; COAGULATION ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; DNA, Bacterial ; ENZIMAS ; ENZYME ; GENE ; Gene Deletion ; GENES ; LACTOCOCCUS LACTIS ; Lactococcus lactis - enzymology ; Lactococcus lactis - genetics ; LAIT ; LECHE ; Membrane Proteins ; Membrane Transport Proteins - genetics ; Milk - metabolism ; Molecular Sequence Data ; PEPTIDE ; PEPTIDOS ; Phenotype ; PLASMIDE ; PLASMIDIOS ; Plasmids ; PROTEASAS ; PROTEASE ; PROTEINAS ; PROTEINE ; SECUENCIA NUCLEOTIDICA ; SEQUENCE NUCLEOTIDIQUE ; Serine Endopeptidases</subject><ispartof>Plasmid, 1996-05, Vol.35 (3), p.145-155</ispartof><rights>1996 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-ced83a02b4bcfbb2c69205e3e39225c8bf64ed30a54abc294008a6701aeb301b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0147619X96900177$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8812781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Weizhu</creatorcontrib><creatorcontrib>Gillies, Kevin</creatorcontrib><creatorcontrib>Kondo, Jeffery K.</creatorcontrib><creatorcontrib>Broadbent, Jeffery R.</creatorcontrib><creatorcontrib>McKay, Larry L.</creatorcontrib><title>Loss of Plasmid-Mediated Oligopeptide Transport System in Lactococci: Another Reason for Slow Milk Coagulation</title><title>Plasmid</title><addtitle>Plasmid</addtitle><description>Fast milk-coagulating (Fmc+) strains of lactococci are known to segregate slow milk-coagulating (Fmc−) variants, which has been attributed to loss of proteinase (Prt) activity encoded by plasmid DNA. It was found that the Fmc−phenotype could also be due to loss of a plasmid encoding an oligopeptide permease (Opp) system. InLactococcus lactissubsp.lactis(L. lactis) C2O, lactose metabolism (Lac) and Prt were linked to pJK550 and the Opp system to pJK430. InLactococcus lactissubsp.cremorisSK11, known to possess Prt on a 78-kb plasmid, DNA sequence analysis of a 7.4-kb region from the Lac plasmid, pSK11L, revealed that it possessed the Opp system. The Lac plasmid inL. lactisC2 encoded both the Prt and Opp systems. Fmc−derivatives ofL. lactisC2 were missing theprtgenes and had Opp integrated into the chromosome, possibly due to transposition events. Growth studies showed the Opp systems were functional and, in combination with Prt, produced the Fmc+phenotype.</description><subject>ACIDE ORGANIQUE</subject><subject>ACIDOS ORGANICOS</subject><subject>Animals</subject><subject>BACTERIA</subject><subject>Bacterial Proteins - genetics</subject><subject>Base Sequence</subject><subject>BIOSINTESIS</subject><subject>BIOSYNTHESE</subject><subject>COAGULACION</subject><subject>COAGULATION</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>DNA, Bacterial</subject><subject>ENZIMAS</subject><subject>ENZYME</subject><subject>GENE</subject><subject>Gene Deletion</subject><subject>GENES</subject><subject>LACTOCOCCUS LACTIS</subject><subject>Lactococcus lactis - enzymology</subject><subject>Lactococcus lactis - genetics</subject><subject>LAIT</subject><subject>LECHE</subject><subject>Membrane Proteins</subject><subject>Membrane Transport Proteins - genetics</subject><subject>Milk - metabolism</subject><subject>Molecular Sequence Data</subject><subject>PEPTIDE</subject><subject>PEPTIDOS</subject><subject>Phenotype</subject><subject>PLASMIDE</subject><subject>PLASMIDIOS</subject><subject>Plasmids</subject><subject>PROTEASAS</subject><subject>PROTEASE</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>SECUENCIA NUCLEOTIDICA</subject><subject>SEQUENCE NUCLEOTIDIQUE</subject><subject>Serine Endopeptidases</subject><issn>0147-619X</issn><issn>1095-9890</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2LFDEUxIMo67h69SAIOXnr8SXdnU68LYNfMMuKswveQpJ-PUa7O71JRtn_3gwzeBNP7_CrqgdVhLxksGYA4u0ymrRmSok1AOsekRUD1VZKKnhMVsCarhJMfXtKnqX0A4qBM3FBLqRkvJNsReZtSImGgX4pOZPvq2vsvcnY05vR78OCS_Y90tto5rSEmOnuIWWcqJ_p1rgcXHDOv6NXc8jfMdKvaFKY6RAi3Y3hN73240-6CWZ_GE32YX5OngxmTPjifC_J3Yf3t5tP1fbm4-fN1bZyDW9z5bCXtQFuG-sGa7kTikOLNdaK89ZJO4gG-xpM2xjruGoApBEdMIO2BmbrS_LmlLvEcH_AlPXkk8NxNDOGQ9KdrDvWKvVfIWu7rgXRFeH6JHSxNBZx0Ev0k4kPmoE-LqGPS-jjEvq4RDG8Picf7IT9X_m5-sJfnfhggjb76JO-2ynBZQNtgfIEsZT0y2PUyXmcSy8-osu6D_5ff_8ApiWhIA</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>Yu, Weizhu</creator><creator>Gillies, Kevin</creator><creator>Kondo, Jeffery K.</creator><creator>Broadbent, Jeffery R.</creator><creator>McKay, Larry L.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19960501</creationdate><title>Loss of Plasmid-Mediated Oligopeptide Transport System in Lactococci: Another Reason for Slow Milk Coagulation</title><author>Yu, Weizhu ; Gillies, Kevin ; Kondo, Jeffery K. ; Broadbent, Jeffery R. ; McKay, Larry L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-ced83a02b4bcfbb2c69205e3e39225c8bf64ed30a54abc294008a6701aeb301b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>ACIDE ORGANIQUE</topic><topic>ACIDOS ORGANICOS</topic><topic>Animals</topic><topic>BACTERIA</topic><topic>Bacterial Proteins - genetics</topic><topic>Base Sequence</topic><topic>BIOSINTESIS</topic><topic>BIOSYNTHESE</topic><topic>COAGULACION</topic><topic>COAGULATION</topic><topic>COMPOSICION QUIMICA</topic><topic>COMPOSITION CHIMIQUE</topic><topic>DNA, Bacterial</topic><topic>ENZIMAS</topic><topic>ENZYME</topic><topic>GENE</topic><topic>Gene Deletion</topic><topic>GENES</topic><topic>LACTOCOCCUS LACTIS</topic><topic>Lactococcus lactis - enzymology</topic><topic>Lactococcus lactis - genetics</topic><topic>LAIT</topic><topic>LECHE</topic><topic>Membrane Proteins</topic><topic>Membrane Transport Proteins - genetics</topic><topic>Milk - metabolism</topic><topic>Molecular Sequence Data</topic><topic>PEPTIDE</topic><topic>PEPTIDOS</topic><topic>Phenotype</topic><topic>PLASMIDE</topic><topic>PLASMIDIOS</topic><topic>Plasmids</topic><topic>PROTEASAS</topic><topic>PROTEASE</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>SECUENCIA NUCLEOTIDICA</topic><topic>SEQUENCE NUCLEOTIDIQUE</topic><topic>Serine Endopeptidases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Weizhu</creatorcontrib><creatorcontrib>Gillies, Kevin</creatorcontrib><creatorcontrib>Kondo, Jeffery K.</creatorcontrib><creatorcontrib>Broadbent, Jeffery R.</creatorcontrib><creatorcontrib>McKay, Larry L.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Plasmid</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Weizhu</au><au>Gillies, Kevin</au><au>Kondo, Jeffery K.</au><au>Broadbent, Jeffery R.</au><au>McKay, Larry L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of Plasmid-Mediated Oligopeptide Transport System in Lactococci: Another Reason for Slow Milk Coagulation</atitle><jtitle>Plasmid</jtitle><addtitle>Plasmid</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>35</volume><issue>3</issue><spage>145</spage><epage>155</epage><pages>145-155</pages><issn>0147-619X</issn><eissn>1095-9890</eissn><abstract>Fast milk-coagulating (Fmc+) strains of lactococci are known to segregate slow milk-coagulating (Fmc−) variants, which has been attributed to loss of proteinase (Prt) activity encoded by plasmid DNA. It was found that the Fmc−phenotype could also be due to loss of a plasmid encoding an oligopeptide permease (Opp) system. InLactococcus lactissubsp.lactis(L. lactis) C2O, lactose metabolism (Lac) and Prt were linked to pJK550 and the Opp system to pJK430. InLactococcus lactissubsp.cremorisSK11, known to possess Prt on a 78-kb plasmid, DNA sequence analysis of a 7.4-kb region from the Lac plasmid, pSK11L, revealed that it possessed the Opp system. The Lac plasmid inL. lactisC2 encoded both the Prt and Opp systems. Fmc−derivatives ofL. lactisC2 were missing theprtgenes and had Opp integrated into the chromosome, possibly due to transposition events. Growth studies showed the Opp systems were functional and, in combination with Prt, produced the Fmc+phenotype.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8812781</pmid><doi>10.1006/plas.1996.0017</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Plasmid, 1996-05, Vol.35 (3), p.145-155 |
| issn | 0147-619X 1095-9890 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ACIDE ORGANIQUE ACIDOS ORGANICOS Animals BACTERIA Bacterial Proteins - genetics Base Sequence BIOSINTESIS BIOSYNTHESE COAGULACION COAGULATION COMPOSICION QUIMICA COMPOSITION CHIMIQUE DNA, Bacterial ENZIMAS ENZYME GENE Gene Deletion GENES LACTOCOCCUS LACTIS Lactococcus lactis - enzymology Lactococcus lactis - genetics LAIT LECHE Membrane Proteins Membrane Transport Proteins - genetics Milk - metabolism Molecular Sequence Data PEPTIDE PEPTIDOS Phenotype PLASMIDE PLASMIDIOS Plasmids PROTEASAS PROTEASE PROTEINAS PROTEINE SECUENCIA NUCLEOTIDICA SEQUENCE NUCLEOTIDIQUE Serine Endopeptidases |
| title | Loss of Plasmid-Mediated Oligopeptide Transport System in Lactococci: Another Reason for Slow Milk Coagulation |
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