Effect of L-dopa on visual evoked potentials and neuropsychological tests in adult phenylketonuria patients

Eight adult, untreated patients with classical phenylketonuria received L-dopa and a decarboxylase inhibitor for 2 weeks. No effect of L-dopa therapy on choice reaction time tasks, sustained attention, frontal lobal function as well as latencies of visual evoked potentials was found. The results rai...

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Veröffentlicht in:	European journal of pediatrics 1996-07, Vol.155 Suppl 1 (S1), p.S74-S77
Hauptverfasser:	Ullrich, K, Weglage, J, Oberwittler, C, Pietsch, M, Fünders, B, von Eckardstein, H, Colombo, J P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Attention Dihydroxyphenylalanine Dopamine Evoked potentials Evoked Potentials, Somatosensory - drug effects Humans Laboratories Levodopa Levodopa - pharmacology Levodopa - therapeutic use Neuropsychological Tests Neuropsychology Parkinson's disease Phenylalanine - blood Phenylketonuria Phenylketonurias - blood Phenylketonurias - drug therapy Phenylketonurias - physiopathology Reaction Time - drug effects Reaction time task Treatment Outcome Visual evoked potentials Visual perception
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Zusammenfassung:	Eight adult, untreated patients with classical phenylketonuria received L-dopa and a decarboxylase inhibitor for 2 weeks. No effect of L-dopa therapy on choice reaction time tasks, sustained attention, frontal lobal function as well as latencies of visual evoked potentials was found. The results raise the question if adult patients with phenylketonuria really suffer from functional dopamine deficiency.
ISSN:	0340-6199 1432-1076
DOI:	10.1007/PL00014256