Regulation of DNA Repair Kinetics in Proliferative and Quiescent Tumor Cells
Summary The radiosensitivity and kinetics of repair of radiation-induced DNA damage were determined for proliferative (P) and quiescent (Q) cells of the mouse mammary adenocarcinoma line 67. 67 Q cells are more radiosensitive than 67 P cells. Radiation induced the same amount of DNA damage in both 6...
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| Veröffentlicht in: | International journal of radiation biology 1988, Vol.54 (2), p.245-255 |
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| container_issue | 2 |
| container_start_page | 245 |
| container_title | International journal of radiation biology |
| container_volume | 54 |
| creator | Wheeler, Kenneth T. Nelson, Garret B. Terrell, Kathryn E. Wallen, C. Anne |
| description | Summary
The radiosensitivity and kinetics of repair of radiation-induced DNA damage were determined for proliferative (P) and quiescent (Q) cells of the mouse mammary adenocarcinoma line 67. 67 Q cells are more radiosensitive than 67 P cells. Radiation induced the same amount of DNA damage in both 67 P and 67 Q cells. Both 67 P and 67 Q cells repaired their DNA damage with biphasic kinetics, but the half-times for the fast and slow phase were longer in 67 Q cells. Q cell DNA appeared to be in a more compact or condensed chromatin structure and was less accessible to enzymatic digestion than P cell DNA. These data suggest that 67 Q cells are more sensitive to ionizing radiation than 67 P cells because they repair their radiation-induced DNA damage more slowly, perhaps as a result of their more condensed chromatin structure. |
| doi_str_mv | 10.1080/09553008814551681 |
| format | Article |
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The radiosensitivity and kinetics of repair of radiation-induced DNA damage were determined for proliferative (P) and quiescent (Q) cells of the mouse mammary adenocarcinoma line 67. 67 Q cells are more radiosensitive than 67 P cells. Radiation induced the same amount of DNA damage in both 67 P and 67 Q cells. Both 67 P and 67 Q cells repaired their DNA damage with biphasic kinetics, but the half-times for the fast and slow phase were longer in 67 Q cells. Q cell DNA appeared to be in a more compact or condensed chromatin structure and was less accessible to enzymatic digestion than P cell DNA. These data suggest that 67 Q cells are more sensitive to ionizing radiation than 67 P cells because they repair their radiation-induced DNA damage more slowly, perhaps as a result of their more condensed chromatin structure.</description><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553008814551681</identifier><identifier>PMID: 2900281</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Adenocarcinoma - veterinary ; Animals ; Cell Line ; DNA - radiation effects ; DNA Damage ; DNA Repair ; In Vitro Techniques ; Kinetics ; Mammary Glands, Animal ; Mice ; Space life sciences</subject><ispartof>International journal of radiation biology, 1988, Vol.54 (2), p.245-255</ispartof><rights>1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-6e91a79e20916c9ce292b8448512ca91f04aea1a17ac54dc847346366cbca3b3</citedby><cites>FETCH-LOGICAL-c401t-6e91a79e20916c9ce292b8448512ca91f04aea1a17ac54dc847346366cbca3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553008814551681$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553008814551681$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2900281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wheeler, Kenneth T.</creatorcontrib><creatorcontrib>Nelson, Garret B.</creatorcontrib><creatorcontrib>Terrell, Kathryn E.</creatorcontrib><creatorcontrib>Wallen, C. Anne</creatorcontrib><title>Regulation of DNA Repair Kinetics in Proliferative and Quiescent Tumor Cells</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol</addtitle><description>Summary
The radiosensitivity and kinetics of repair of radiation-induced DNA damage were determined for proliferative (P) and quiescent (Q) cells of the mouse mammary adenocarcinoma line 67. 67 Q cells are more radiosensitive than 67 P cells. Radiation induced the same amount of DNA damage in both 67 P and 67 Q cells. Both 67 P and 67 Q cells repaired their DNA damage with biphasic kinetics, but the half-times for the fast and slow phase were longer in 67 Q cells. Q cell DNA appeared to be in a more compact or condensed chromatin structure and was less accessible to enzymatic digestion than P cell DNA. These data suggest that 67 Q cells are more sensitive to ionizing radiation than 67 P cells because they repair their radiation-induced DNA damage more slowly, perhaps as a result of their more condensed chromatin structure.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - veterinary</subject><subject>Animals</subject><subject>Cell Line</subject><subject>DNA - radiation effects</subject><subject>DNA Damage</subject><subject>DNA Repair</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Mammary Glands, Animal</subject><subject>Mice</subject><subject>Space life sciences</subject><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtqGzEUhkVpcZw0D9BFQavunEgjzYyGdmOcKzFNY7wXx_KZWkYjudJMQ94-MjaBUsjq_PBfOHyEfOHsgjPFLllTloIxpbgsS14p_oGMuaiKicjORzLe-1mz4oScprRlWTGhRmRUNFkqPibzBf4eHPQ2eBpaevVzShe4Axvpg_XYW5Oo9fRXDM62GHPuL1Lwa_o0WEwGfU-XQxcinaFz6TP51IJLeH68Z2R5c72c3U3mj7f3s-l8YiTj_aTChkPdYMEaXpnGYNEUKyWlKnlhoOEtk4DAgddgSrk2StZCVqKqzMqAWIkz8u0wu4vhz4Cp153NvzgHHsOQdK1EpWopc5AfgiaGlCK2ehdtB_FFc6b3APV_AHPn63F8WHW4fmsciWX_x8G3vg2xg-cQ3Vr38OJCbCN4Y5MW781__6e-QXD9xkBEvQ1D9BnbO8-9AiJ9j04</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Wheeler, Kenneth T.</creator><creator>Nelson, Garret B.</creator><creator>Terrell, Kathryn E.</creator><creator>Wallen, C. Anne</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Regulation of DNA Repair Kinetics in Proliferative and Quiescent Tumor Cells</title><author>Wheeler, Kenneth T. ; Nelson, Garret B. ; Terrell, Kathryn E. ; Wallen, C. Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-6e91a79e20916c9ce292b8448512ca91f04aea1a17ac54dc847346366cbca3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - veterinary</topic><topic>Animals</topic><topic>Cell Line</topic><topic>DNA - radiation effects</topic><topic>DNA Damage</topic><topic>DNA Repair</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Mammary Glands, Animal</topic><topic>Mice</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wheeler, Kenneth T.</creatorcontrib><creatorcontrib>Nelson, Garret B.</creatorcontrib><creatorcontrib>Terrell, Kathryn E.</creatorcontrib><creatorcontrib>Wallen, C. Anne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wheeler, Kenneth T.</au><au>Nelson, Garret B.</au><au>Terrell, Kathryn E.</au><au>Wallen, C. Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of DNA Repair Kinetics in Proliferative and Quiescent Tumor Cells</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1988</date><risdate>1988</risdate><volume>54</volume><issue>2</issue><spage>245</spage><epage>255</epage><pages>245-255</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>Summary
The radiosensitivity and kinetics of repair of radiation-induced DNA damage were determined for proliferative (P) and quiescent (Q) cells of the mouse mammary adenocarcinoma line 67. 67 Q cells are more radiosensitive than 67 P cells. Radiation induced the same amount of DNA damage in both 67 P and 67 Q cells. Both 67 P and 67 Q cells repaired their DNA damage with biphasic kinetics, but the half-times for the fast and slow phase were longer in 67 Q cells. Q cell DNA appeared to be in a more compact or condensed chromatin structure and was less accessible to enzymatic digestion than P cell DNA. These data suggest that 67 Q cells are more sensitive to ionizing radiation than 67 P cells because they repair their radiation-induced DNA damage more slowly, perhaps as a result of their more condensed chromatin structure.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>2900281</pmid><doi>10.1080/09553008814551681</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | International journal of radiation biology, 1988, Vol.54 (2), p.245-255 |
| issn | 0955-3002 1362-3095 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78368744 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma - veterinary Animals Cell Line DNA - radiation effects DNA Damage DNA Repair In Vitro Techniques Kinetics Mammary Glands, Animal Mice Space life sciences |
| title | Regulation of DNA Repair Kinetics in Proliferative and Quiescent Tumor Cells |
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