Oxidant defense systems in testes from zinc-deficient rats
Previous studies have demonstrated that zinc deficiency can be associated with high rates of oxidative damage to testes lipids, proteins, and DNA in male rats. In the present work, different aspects of the oxidant defense system (enzymes and lipid-soluble antioxidant substances) were characterized i...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1996-10, Vol.213 (1), p.85-91 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
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| creator | Oteiza, P.L. (Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina.) Olin, K.L Fraga, C.G Keen, C.L |
| description | Previous studies have demonstrated that zinc deficiency can be associated with high rates of oxidative damage to testes lipids, proteins, and DNA in male rats. In the present work, different aspects of the oxidant defense system (enzymes and lipid-soluble antioxidant substances) were characterized in the testes of control and zinc-deficient rats. Seventeen-day-old males were given free access to either a control (25 microgram Zn/g) or a zinc-deficient (0.5 microgram Zn/g) diet, or the 25 microgram Zn/g diet at a level of food intake similar to that of zinc-deficient rats. Animals were sacrificed 14 days after the initiation of the diet. The activities of copper-zinc superoxide dismutase (CuZn SOD) and glutathione reductase (GRed) were significantly higher (34% and 23%, respectively) in testes from the zinc-deficient animals than in those of the ad libitum controls. In testes, the activities of manganese superoxide dismutase (Mn SOD) and glutathione peroxidase (GPx), and the concentration of alpha-tocopherol and ubiquinol-9 and -10 were similar among the groups. However, the ratio of reduced/total concentration of both ubiquinols was higher in the zinc-deficient and restrict-fed animals than in the ad libitum controls. Testes homogenates from the zinc-deficient rats showed a low susceptibility to Fe (II)-induced oxidation, which could be explained in part by a lower peroxidation index, mainly due to the decreased testicular content of the fatty acid 20:4 observed in these animals. In summary, both undernutrition and zinc deficiency can cause an oxidative stress situation in testes, for which cells tend to compensate by increasing select components of the oxidant defense system |
| doi_str_mv | 10.3181/00379727-213-44040 |
| format | Article |
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(Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina.) ; Olin, K.L ; Fraga, C.G ; Keen, C.L</creator><creatorcontrib>Oteiza, P.L. (Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina.) ; Olin, K.L ; Fraga, C.G ; Keen, C.L</creatorcontrib><description>Previous studies have demonstrated that zinc deficiency can be associated with high rates of oxidative damage to testes lipids, proteins, and DNA in male rats. In the present work, different aspects of the oxidant defense system (enzymes and lipid-soluble antioxidant substances) were characterized in the testes of control and zinc-deficient rats. Seventeen-day-old males were given free access to either a control (25 microgram Zn/g) or a zinc-deficient (0.5 microgram Zn/g) diet, or the 25 microgram Zn/g diet at a level of food intake similar to that of zinc-deficient rats. Animals were sacrificed 14 days after the initiation of the diet. The activities of copper-zinc superoxide dismutase (CuZn SOD) and glutathione reductase (GRed) were significantly higher (34% and 23%, respectively) in testes from the zinc-deficient animals than in those of the ad libitum controls. In testes, the activities of manganese superoxide dismutase (Mn SOD) and glutathione peroxidase (GPx), and the concentration of alpha-tocopherol and ubiquinol-9 and -10 were similar among the groups. However, the ratio of reduced/total concentration of both ubiquinols was higher in the zinc-deficient and restrict-fed animals than in the ad libitum controls. Testes homogenates from the zinc-deficient rats showed a low susceptibility to Fe (II)-induced oxidation, which could be explained in part by a lower peroxidation index, mainly due to the decreased testicular content of the fatty acid 20:4 observed in these animals. In summary, both undernutrition and zinc deficiency can cause an oxidative stress situation in testes, for which cells tend to compensate by increasing select components of the oxidant defense system</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1525-1373</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-213-44040</identifier><identifier>PMID: 8820828</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>ACTIVIDAD ENZIMATICA ; ACTIVITE ENZYMATIQUE ; ADN ; Animals ; ANTIOXIDANTES ; ANTIOXYDANT ; Body Weight ; CARENCE EN OLIGOELEMENT ; CINC ; Copper - blood ; DEFICIENCIA DE OLIGOELEMENTOS ; ESTRES ; GLUTATHION PEROXYDASE ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - metabolism ; GLUTATION PEROXIDASA ; LIPIDE ; LIPIDOS ; Male ; MALNUTRICION ; MALNUTRITION ; MECANISME DE DEFENSE ; MECANISMOS DE DEFENSA ; Organ Size ; OXIDACION ; Oxidative Stress - physiology ; Oxidoreductases - metabolism ; OXIDORREDUCTASAS ; OXYDATION ; OXYDOREDUCTASE ; PEROXIDACION LIPIDICA ; PEROXYDATION DES LIPIDES ; Phospholipids - analysis ; PROTEINAS ; PROTEINE ; RAT ; RATA ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species - metabolism ; STRESS ; Superoxide Dismutase - metabolism ; SUPEROXIDO DISMUTASA ; SUPEROXYDE DISMUTASE ; TESTICULE ; TESTICULOS ; Testis - enzymology ; Testis - metabolism ; Testis - pathology ; Thiobarbituric Acid Reactive Substances - analysis ; Thiobarbituric Acid Reactive Substances - metabolism ; Ubiquinone - analogs & derivatives ; Ubiquinone - analysis ; Vitamin E - analysis ; ZINC ; Zinc - blood ; Zinc - deficiency</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1996-10, Vol.213 (1), p.85-91</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-3a3bba8a61003dfa4de8c7c8173fffbbfaa5ab703d0a1546a53481b8f9d5df1c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8820828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oteiza, P.L. (Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina.)</creatorcontrib><creatorcontrib>Olin, K.L</creatorcontrib><creatorcontrib>Fraga, C.G</creatorcontrib><creatorcontrib>Keen, C.L</creatorcontrib><title>Oxidant defense systems in testes from zinc-deficient rats</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Previous studies have demonstrated that zinc deficiency can be associated with high rates of oxidative damage to testes lipids, proteins, and DNA in male rats. In the present work, different aspects of the oxidant defense system (enzymes and lipid-soluble antioxidant substances) were characterized in the testes of control and zinc-deficient rats. Seventeen-day-old males were given free access to either a control (25 microgram Zn/g) or a zinc-deficient (0.5 microgram Zn/g) diet, or the 25 microgram Zn/g diet at a level of food intake similar to that of zinc-deficient rats. Animals were sacrificed 14 days after the initiation of the diet. The activities of copper-zinc superoxide dismutase (CuZn SOD) and glutathione reductase (GRed) were significantly higher (34% and 23%, respectively) in testes from the zinc-deficient animals than in those of the ad libitum controls. In testes, the activities of manganese superoxide dismutase (Mn SOD) and glutathione peroxidase (GPx), and the concentration of alpha-tocopherol and ubiquinol-9 and -10 were similar among the groups. However, the ratio of reduced/total concentration of both ubiquinols was higher in the zinc-deficient and restrict-fed animals than in the ad libitum controls. Testes homogenates from the zinc-deficient rats showed a low susceptibility to Fe (II)-induced oxidation, which could be explained in part by a lower peroxidation index, mainly due to the decreased testicular content of the fatty acid 20:4 observed in these animals. In summary, both undernutrition and zinc deficiency can cause an oxidative stress situation in testes, for which cells tend to compensate by increasing select components of the oxidant defense system</description><subject>ACTIVIDAD ENZIMATICA</subject><subject>ACTIVITE ENZYMATIQUE</subject><subject>ADN</subject><subject>Animals</subject><subject>ANTIOXIDANTES</subject><subject>ANTIOXYDANT</subject><subject>Body Weight</subject><subject>CARENCE EN OLIGOELEMENT</subject><subject>CINC</subject><subject>Copper - blood</subject><subject>DEFICIENCIA DE OLIGOELEMENTOS</subject><subject>ESTRES</subject><subject>GLUTATHION PEROXYDASE</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - metabolism</subject><subject>GLUTATION PEROXIDASA</subject><subject>LIPIDE</subject><subject>LIPIDOS</subject><subject>Male</subject><subject>MALNUTRICION</subject><subject>MALNUTRITION</subject><subject>MECANISME DE DEFENSE</subject><subject>MECANISMOS DE DEFENSA</subject><subject>Organ Size</subject><subject>OXIDACION</subject><subject>Oxidative Stress - physiology</subject><subject>Oxidoreductases - metabolism</subject><subject>OXIDORREDUCTASAS</subject><subject>OXYDATION</subject><subject>OXYDOREDUCTASE</subject><subject>PEROXIDACION LIPIDICA</subject><subject>PEROXYDATION DES LIPIDES</subject><subject>Phospholipids - analysis</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>RAT</subject><subject>RATA</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>STRESS</subject><subject>Superoxide Dismutase - metabolism</subject><subject>SUPEROXIDO DISMUTASA</subject><subject>SUPEROXYDE DISMUTASE</subject><subject>TESTICULE</subject><subject>TESTICULOS</subject><subject>Testis - enzymology</subject><subject>Testis - metabolism</subject><subject>Testis - pathology</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Ubiquinone - analysis</subject><subject>Vitamin E - analysis</subject><subject>ZINC</subject><subject>Zinc - blood</subject><subject>Zinc - deficiency</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1525-1373</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAYhYMoc07_wEDolXdx-Wib1DsZ8wMGu9Bdh7dpMjLWdiYtOH-9mZ1eepXAec7hvAehKSX3nEo6I4SLQjCBGeU4TUlKztCYZizDlAt-jsZHAB-JS3QVwpYQkhNGRmgkJSOSyTF6WH26CpouqYw1TTBJOITO1CFxTdKZ-A2J9W2dfLlG48g47UykPXThGl1Y2AVzc3onaP20eJ-_4OXq-XX-uMSaZ6LDHHhZgoScxjaVhbQyUgstqeDW2rK0ABmUImoEaJbmkPFU0lLaosoqSzWfoLshd-_bjz52UrUL2ux20Ji2D0pInjNCaQTZAGrfhuCNVXvvavAHRYk6DqZ-B1NxMPUzWDTdntL7sjbVn-W0UNRngx5gY9S27X0Tj_0_cTo4LLQKNt4FtX4r4oFF7PgNPO98HA</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Oteiza, P.L. (Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina.)</creator><creator>Olin, K.L</creator><creator>Fraga, C.G</creator><creator>Keen, C.L</creator><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961001</creationdate><title>Oxidant defense systems in testes from zinc-deficient rats</title><author>Oteiza, P.L. (Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina.) ; Olin, K.L ; Fraga, C.G ; Keen, C.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-3a3bba8a61003dfa4de8c7c8173fffbbfaa5ab703d0a1546a53481b8f9d5df1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>ACTIVIDAD ENZIMATICA</topic><topic>ACTIVITE ENZYMATIQUE</topic><topic>ADN</topic><topic>Animals</topic><topic>ANTIOXIDANTES</topic><topic>ANTIOXYDANT</topic><topic>Body Weight</topic><topic>CARENCE EN OLIGOELEMENT</topic><topic>CINC</topic><topic>Copper - blood</topic><topic>DEFICIENCIA DE OLIGOELEMENTOS</topic><topic>ESTRES</topic><topic>GLUTATHION PEROXYDASE</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - metabolism</topic><topic>GLUTATION PEROXIDASA</topic><topic>LIPIDE</topic><topic>LIPIDOS</topic><topic>Male</topic><topic>MALNUTRICION</topic><topic>MALNUTRITION</topic><topic>MECANISME DE DEFENSE</topic><topic>MECANISMOS DE DEFENSA</topic><topic>Organ Size</topic><topic>OXIDACION</topic><topic>Oxidative Stress - physiology</topic><topic>Oxidoreductases - metabolism</topic><topic>OXIDORREDUCTASAS</topic><topic>OXYDATION</topic><topic>OXYDOREDUCTASE</topic><topic>PEROXIDACION LIPIDICA</topic><topic>PEROXYDATION DES LIPIDES</topic><topic>Phospholipids - analysis</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>RAT</topic><topic>RATA</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>STRESS</topic><topic>Superoxide Dismutase - metabolism</topic><topic>SUPEROXIDO DISMUTASA</topic><topic>SUPEROXYDE DISMUTASE</topic><topic>TESTICULE</topic><topic>TESTICULOS</topic><topic>Testis - enzymology</topic><topic>Testis - metabolism</topic><topic>Testis - pathology</topic><topic>Thiobarbituric Acid Reactive Substances - analysis</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>Ubiquinone - analysis</topic><topic>Vitamin E - analysis</topic><topic>ZINC</topic><topic>Zinc - blood</topic><topic>Zinc - deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oteiza, P.L. (Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina.)</creatorcontrib><creatorcontrib>Olin, K.L</creatorcontrib><creatorcontrib>Fraga, C.G</creatorcontrib><creatorcontrib>Keen, C.L</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oteiza, P.L. (Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina.)</au><au>Olin, K.L</au><au>Fraga, C.G</au><au>Keen, C.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidant defense systems in testes from zinc-deficient rats</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>213</volume><issue>1</issue><spage>85</spage><epage>91</epage><pages>85-91</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1525-1373</eissn><eissn>1535-3699</eissn><abstract>Previous studies have demonstrated that zinc deficiency can be associated with high rates of oxidative damage to testes lipids, proteins, and DNA in male rats. In the present work, different aspects of the oxidant defense system (enzymes and lipid-soluble antioxidant substances) were characterized in the testes of control and zinc-deficient rats. Seventeen-day-old males were given free access to either a control (25 microgram Zn/g) or a zinc-deficient (0.5 microgram Zn/g) diet, or the 25 microgram Zn/g diet at a level of food intake similar to that of zinc-deficient rats. Animals were sacrificed 14 days after the initiation of the diet. The activities of copper-zinc superoxide dismutase (CuZn SOD) and glutathione reductase (GRed) were significantly higher (34% and 23%, respectively) in testes from the zinc-deficient animals than in those of the ad libitum controls. In testes, the activities of manganese superoxide dismutase (Mn SOD) and glutathione peroxidase (GPx), and the concentration of alpha-tocopherol and ubiquinol-9 and -10 were similar among the groups. However, the ratio of reduced/total concentration of both ubiquinols was higher in the zinc-deficient and restrict-fed animals than in the ad libitum controls. Testes homogenates from the zinc-deficient rats showed a low susceptibility to Fe (II)-induced oxidation, which could be explained in part by a lower peroxidation index, mainly due to the decreased testicular content of the fatty acid 20:4 observed in these animals. In summary, both undernutrition and zinc deficiency can cause an oxidative stress situation in testes, for which cells tend to compensate by increasing select components of the oxidant defense system</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>8820828</pmid><doi>10.3181/00379727-213-44040</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 1996-10, Vol.213 (1), p.85-91 |
| issn | 0037-9727 1535-3702 1525-1373 1535-3699 |
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| subjects | ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE ADN Animals ANTIOXIDANTES ANTIOXYDANT Body Weight CARENCE EN OLIGOELEMENT CINC Copper - blood DEFICIENCIA DE OLIGOELEMENTOS ESTRES GLUTATHION PEROXYDASE Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism GLUTATION PEROXIDASA LIPIDE LIPIDOS Male MALNUTRICION MALNUTRITION MECANISME DE DEFENSE MECANISMOS DE DEFENSA Organ Size OXIDACION Oxidative Stress - physiology Oxidoreductases - metabolism OXIDORREDUCTASAS OXYDATION OXYDOREDUCTASE PEROXIDACION LIPIDICA PEROXYDATION DES LIPIDES Phospholipids - analysis PROTEINAS PROTEINE RAT RATA Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism STRESS Superoxide Dismutase - metabolism SUPEROXIDO DISMUTASA SUPEROXYDE DISMUTASE TESTICULE TESTICULOS Testis - enzymology Testis - metabolism Testis - pathology Thiobarbituric Acid Reactive Substances - analysis Thiobarbituric Acid Reactive Substances - metabolism Ubiquinone - analogs & derivatives Ubiquinone - analysis Vitamin E - analysis ZINC Zinc - blood Zinc - deficiency |
| title | Oxidant defense systems in testes from zinc-deficient rats |
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