Comparative targeting of human colon‐carcinoma multicell spheroids using one‐ and two‐step (bispecific antibody) techniques

In the perspective of radioimmunotherapy (RIT) of micrometastases, we compared, in multicell spheroids (MS), the uptake and retention kinetics of 125I‐F(ab)′2 F6 anti‐carcinoembryonic antigen (CEA) monoclonal antibody (MAb), and the affinity enhancement system (AES) using an anti‐CEA/anti‐DTPA‐indiu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of cancer 1996-09, Vol.67 (6), p.883-891
Hauptverfasser:	Devys, Anne, Thedrez, Philippe, Gautherot, Emmanuel, Faivre‐Chauvet, Alain, Saï‐Maurel, Catherine, Rouvier, Eric, Auget, Jean‐Louis, Barbet, Jacques, Chatal, Jean‐François
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bispecific - pharmacokinetics Antibodies, Bispecific - therapeutic use Biological and medical sciences Carcinoembryonic Antigen - immunology Carcinoembryonic Antigen - metabolism Colonic Neoplasms - immunology Colonic Neoplasms - metabolism Colonic Neoplasms - radiotherapy Half-Life Humans Immunoglobulin Fab Fragments - metabolism Indium Radioisotopes - pharmacokinetics Iodine Radioisotopes - pharmacokinetics Medical sciences Microscopy, Electron, Scanning Radiation therapy and radiosensitizing agent Radioimmunotherapy - methods Spheroids, Cellular - immunology Spheroids, Cellular - metabolism Temperature Time Factors Treatment with physical agents Treatment. General aspects Tumor Cells, Cultured Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!