Prophylaxis with Amoxicillin or Sulfisoxazole for Otitis Media: Effect on the Recovery of Penicillin-Resistant Bacteria from Children
The rate of recovery of oropharyngeal penicillin-resistant Streptococcus pneumoniae and aerobic and anaerobic β-lactamase-producing bacteria (BLPB) from children who received a 4- to 6-month course of prophylaxis with amoxicillin or sulfisoxazole for otitis media was investigated monthly over 9 mont...
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| Veröffentlicht in: | Clinical infectious diseases 1996-01, Vol.22 (1), p.143-145 |
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| creator | Brook, Itzhak Gober, Alan E. |
| description | The rate of recovery of oropharyngeal penicillin-resistant Streptococcus pneumoniae and aerobic and anaerobic β-lactamase-producing bacteria (BLPB) from children who received a 4- to 6-month course of prophylaxis with amoxicillin or sulfisoxazole for otitis media was investigated monthly over 9 months. The BLPB recovered were Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, pigmented Prevotella species, and Fusobacterium species. The recovery rate for all penicillinresistant S. pneumoniae isolates and BLPB increased only after administration of amoxicillin. Before amoxicillin was administered, six BLPB isolates were recovered from four of the children who were to be given this drug (20%). The number of BLPB recovered increased gradually until all of these patients were found to be colonized with BLPB; five (25%) of these patients were found to be colonized with penicillin-resistant S. pneumoniae after 5 months of prophylaxis. Three to five months after amoxicillin prophylaxis was discontinued, the number of BLPB recovered gradually declined; only three children (15%) remained colonized with BLPB, and none remained colonized with penicillin- resistant S. pneumoniae. These data illustrate that amoxicillin prophylaxis induces an increase in the number of penicillin-resistant bacteria in the oropharynx. |
| doi_str_mv | 10.1093/clinids/22.1.143 |
| format | Article |
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The BLPB recovered were Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, pigmented Prevotella species, and Fusobacterium species. The recovery rate for all penicillinresistant S. pneumoniae isolates and BLPB increased only after administration of amoxicillin. Before amoxicillin was administered, six BLPB isolates were recovered from four of the children who were to be given this drug (20%). The number of BLPB recovered increased gradually until all of these patients were found to be colonized with BLPB; five (25%) of these patients were found to be colonized with penicillin-resistant S. pneumoniae after 5 months of prophylaxis. Three to five months after amoxicillin prophylaxis was discontinued, the number of BLPB recovered gradually declined; only three children (15%) remained colonized with BLPB, and none remained colonized with penicillin- resistant S. pneumoniae. These data illustrate that amoxicillin prophylaxis induces an increase in the number of penicillin-resistant bacteria in the oropharynx.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/clinids/22.1.143</identifier><identifier>PMID: 8824982</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Amoxicillin - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobials ; Bacteria ; Bacteria - drug effects ; Bacteria - isolation & purification ; Bacteria, Aerobic - drug effects ; Bacteria, Aerobic - isolation & purification ; Bacteria, Anaerobic - drug effects ; Bacteria, Anaerobic - isolation & purification ; Biological and medical sciences ; Child ; Child, Preschool ; Children ; Female ; Haemophilus influenzae ; Humans ; Infant ; Male ; Medical sciences ; Microbial Sensitivity Tests ; Moraxella catarrhalis ; Oropharynx - microbiology ; Otitis media ; Otitis Media - drug therapy ; Otitis Media - microbiology ; Penicillin ; Penicillin Resistance ; Pharmacology. 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The BLPB recovered were Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, pigmented Prevotella species, and Fusobacterium species. The recovery rate for all penicillinresistant S. pneumoniae isolates and BLPB increased only after administration of amoxicillin. Before amoxicillin was administered, six BLPB isolates were recovered from four of the children who were to be given this drug (20%). The number of BLPB recovered increased gradually until all of these patients were found to be colonized with BLPB; five (25%) of these patients were found to be colonized with penicillin-resistant S. pneumoniae after 5 months of prophylaxis. Three to five months after amoxicillin prophylaxis was discontinued, the number of BLPB recovered gradually declined; only three children (15%) remained colonized with BLPB, and none remained colonized with penicillin- resistant S. pneumoniae. These data illustrate that amoxicillin prophylaxis induces an increase in the number of penicillin-resistant bacteria in the oropharynx.</description><subject>Amoxicillin - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobials</subject><subject>Bacteria</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - isolation & purification</subject><subject>Bacteria, Aerobic - drug effects</subject><subject>Bacteria, Aerobic - isolation & purification</subject><subject>Bacteria, Anaerobic - drug effects</subject><subject>Bacteria, Anaerobic - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Female</subject><subject>Haemophilus influenzae</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Moraxella catarrhalis</subject><subject>Oropharynx - microbiology</subject><subject>Otitis media</subject><subject>Otitis Media - drug therapy</subject><subject>Otitis Media - microbiology</subject><subject>Penicillin</subject><subject>Penicillin Resistance</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevotella</subject><subject>Staphylococcus aureus</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Sulfisoxazole - therapeutic use</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEURUcIVEphzwIkLyp2k9oejz_YtVFhUItahYIQG8txnhWXyTjYDiTs-d-4ZJQtK1u-5x09-VbVS4InBKvmzPZ-8It0RumETAhrHlXHpG1EzVtFHpc7bmXNZCOfVs9SuseYEInbo-pISsqUpMfVn9sY1stdb7Y-oV8-L9H5Kmy99X0xoxDRp03vfApb8zv0gFx5uck-F_gjLLx5iy6dA5tRGFBeApqBDT8h7lBw6BaG0VPPIPmUzZDRhbEZojfIxbBC06XvFxGG59UTZ_oEL8bzpPr87vJu2tXXN-8_TM-va8vaNteUYcNNi4lrlTQGC9lwrDgG6uaUcuuwMkAwn4NojLSWCycBpCNKcDW3sjmp3uy96xh-bCBlvfLJQt-bAcIm6X9CKsR_QSIwo5iTAuI9aGNIKYLT6-hXJu40wfqhIj1WpCnVRJeKysjr0b2Zr2BxGBg7KfnpmJtkTe-iGaxPB4wqprBiBXu1x-5TDvEQM1aqlw-L1fu4fDxsD7GJ3zUXjWh19_WbvrvqutmX7kpfNH8Bceq1tQ</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>Brook, Itzhak</creator><creator>Gober, Alan E.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199601</creationdate><title>Prophylaxis with Amoxicillin or Sulfisoxazole for Otitis Media: Effect on the Recovery of Penicillin-Resistant Bacteria from Children</title><author>Brook, Itzhak ; Gober, Alan E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-240a6a501f598aa078360960e2fb226cf09ae106be73a8cc67f8ee8f19769bc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amoxicillin - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimicrobials</topic><topic>Bacteria</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - isolation & purification</topic><topic>Bacteria, Aerobic - drug effects</topic><topic>Bacteria, Aerobic - isolation & purification</topic><topic>Bacteria, Anaerobic - drug effects</topic><topic>Bacteria, Anaerobic - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Female</topic><topic>Haemophilus influenzae</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Moraxella catarrhalis</topic><topic>Oropharynx - microbiology</topic><topic>Otitis media</topic><topic>Otitis Media - drug therapy</topic><topic>Otitis Media - microbiology</topic><topic>Penicillin</topic><topic>Penicillin Resistance</topic><topic>Pharmacology. Drug treatments</topic><topic>Prevotella</topic><topic>Staphylococcus aureus</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - drug effects</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Sulfisoxazole - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brook, Itzhak</creatorcontrib><creatorcontrib>Gober, Alan E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brook, Itzhak</au><au>Gober, Alan E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prophylaxis with Amoxicillin or Sulfisoxazole for Otitis Media: Effect on the Recovery of Penicillin-Resistant Bacteria from Children</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1996-01</date><risdate>1996</risdate><volume>22</volume><issue>1</issue><spage>143</spage><epage>145</epage><pages>143-145</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>The rate of recovery of oropharyngeal penicillin-resistant Streptococcus pneumoniae and aerobic and anaerobic β-lactamase-producing bacteria (BLPB) from children who received a 4- to 6-month course of prophylaxis with amoxicillin or sulfisoxazole for otitis media was investigated monthly over 9 months. The BLPB recovered were Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, pigmented Prevotella species, and Fusobacterium species. The recovery rate for all penicillinresistant S. pneumoniae isolates and BLPB increased only after administration of amoxicillin. Before amoxicillin was administered, six BLPB isolates were recovered from four of the children who were to be given this drug (20%). The number of BLPB recovered increased gradually until all of these patients were found to be colonized with BLPB; five (25%) of these patients were found to be colonized with penicillin-resistant S. pneumoniae after 5 months of prophylaxis. Three to five months after amoxicillin prophylaxis was discontinued, the number of BLPB recovered gradually declined; only three children (15%) remained colonized with BLPB, and none remained colonized with penicillin- resistant S. pneumoniae. These data illustrate that amoxicillin prophylaxis induces an increase in the number of penicillin-resistant bacteria in the oropharynx.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8824982</pmid><doi>10.1093/clinids/22.1.143</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 1996-01, Vol.22 (1), p.143-145 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78360277 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; JSTOR |
| subjects | Amoxicillin - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobials Bacteria Bacteria - drug effects Bacteria - isolation & purification Bacteria, Aerobic - drug effects Bacteria, Aerobic - isolation & purification Bacteria, Anaerobic - drug effects Bacteria, Anaerobic - isolation & purification Biological and medical sciences Child Child, Preschool Children Female Haemophilus influenzae Humans Infant Male Medical sciences Microbial Sensitivity Tests Moraxella catarrhalis Oropharynx - microbiology Otitis media Otitis Media - drug therapy Otitis Media - microbiology Penicillin Penicillin Resistance Pharmacology. Drug treatments Prevotella Staphylococcus aureus Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - isolation & purification Sulfisoxazole - therapeutic use |
| title | Prophylaxis with Amoxicillin or Sulfisoxazole for Otitis Media: Effect on the Recovery of Penicillin-Resistant Bacteria from Children |
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