Measurement of seminal LDH-X and transferrin in normal and infertile men
LDH‐X, an isoenzyme of lactate dehydrogenase specific for germinal epithelium activity, has been measured in the seminal plasma of infertile subjects whose infertility had different origins. In the same samples, seminal transferrin, an index of Sertoli cell function, was also measured. In this inves...
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| Veröffentlicht in: | Journal of andrology 1988-05, Vol.9 (3), p.220-223 |
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| creator | Orlando, C Casano, R Caldini, A. L Forti, G Barni, T Bonfanti, L Serio, M |
| description | LDH‐X, an isoenzyme of lactate dehydrogenase specific for germinal epithelium activity, has been measured in the seminal plasma of infertile subjects whose infertility had different origins. In the same samples, seminal transferrin, an index of Sertoli cell function, was also measured. In this investigation, seminal LDH‐X was not detectable in the vasectomized subjects, in patients with azoospermia due to seminiferous tubular damage, nor in patients who showed a marked decrease in sperm concentration ( |
| doi_str_mv | 10.1002/j.1939-4640.1988.tb01040.x |
| format | Article |
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L ; Forti, G ; Barni, T ; Bonfanti, L ; Serio, M</creator><creatorcontrib>Orlando, C ; Casano, R ; Caldini, A. L ; Forti, G ; Barni, T ; Bonfanti, L ; Serio, M</creatorcontrib><description>LDH‐X, an isoenzyme of lactate dehydrogenase specific for germinal epithelium activity, has been measured in the seminal plasma of infertile subjects whose infertility had different origins. In the same samples, seminal transferrin, an index of Sertoli cell function, was also measured. In this investigation, seminal LDH‐X was not detectable in the vasectomized subjects, in patients with azoospermia due to seminiferous tubular damage, nor in patients who showed a marked decrease in sperm concentration (<1 × 106/ml). In Oligozoospermic patients (sperm concentration < 20 × 106/ml) seminal LDH‐X levels were reduced to about one‐third of those found in normal controls. Seminal LDH‐X levels correlated (r = 0.7237) with total sperm count better than seminal transferrin levels (r = 0.5511), while no correlation was found between these two biochemical parameters and sperm motility, viability and morphology. To study their spontaneous variations with time, LDH‐X and transferrin were also measured in semen specimens collected monthly from five healthy men, over 1 year. In these samples (N = 60), sperm count variability (43.1%, calculated in terms of the coefficient of variation), was similar to that of LDH‐X (40.4%) and higher than for transferrin (23.0%).</description><identifier>ISSN: 0196-3635</identifier><identifier>EISSN: 1939-4640</identifier><identifier>DOI: 10.1002/j.1939-4640.1988.tb01040.x</identifier><identifier>PMID: 3403363</identifier><identifier>CODEN: JOAND3</identifier><language>eng</language><publisher>Oxford, UK: Am Soc Andrology</publisher><subject>Adult ; azoospermia ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Humans ; Isoenzymes ; Kinetics ; L-Lactate Dehydrogenase - analysis ; LDH‐X ; Male ; Mammalian male genital system ; Morphology. Physiology ; Oligospermia - enzymology ; Oligospermia - metabolism ; oligozoospermia ; Semen - analysis ; Semen - enzymology ; seminal biochemical parameters ; Sertoli Cells - physiology ; sperm count ; transferrin ; Transferrin - analysis ; variability in semen characteristics ; Vasectomy ; Vertebrates: reproduction</subject><ispartof>Journal of andrology, 1988-05, Vol.9 (3), p.220-223</ispartof><rights>1988 American Society of Andrology</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4810-c6dd10f351b10313ba630aad5dc12dd32794bb6dee0278b7a41e0528966cd8a63</citedby><cites>FETCH-LOGICAL-c4810-c6dd10f351b10313ba630aad5dc12dd32794bb6dee0278b7a41e0528966cd8a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6710974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3403363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orlando, C</creatorcontrib><creatorcontrib>Casano, R</creatorcontrib><creatorcontrib>Caldini, A. L</creatorcontrib><creatorcontrib>Forti, G</creatorcontrib><creatorcontrib>Barni, T</creatorcontrib><creatorcontrib>Bonfanti, L</creatorcontrib><creatorcontrib>Serio, M</creatorcontrib><title>Measurement of seminal LDH-X and transferrin in normal and infertile men</title><title>Journal of andrology</title><addtitle>J Androl</addtitle><description>LDH‐X, an isoenzyme of lactate dehydrogenase specific for germinal epithelium activity, has been measured in the seminal plasma of infertile subjects whose infertility had different origins. In the same samples, seminal transferrin, an index of Sertoli cell function, was also measured. In this investigation, seminal LDH‐X was not detectable in the vasectomized subjects, in patients with azoospermia due to seminiferous tubular damage, nor in patients who showed a marked decrease in sperm concentration (<1 × 106/ml). In Oligozoospermic patients (sperm concentration < 20 × 106/ml) seminal LDH‐X levels were reduced to about one‐third of those found in normal controls. Seminal LDH‐X levels correlated (r = 0.7237) with total sperm count better than seminal transferrin levels (r = 0.5511), while no correlation was found between these two biochemical parameters and sperm motility, viability and morphology. To study their spontaneous variations with time, LDH‐X and transferrin were also measured in semen specimens collected monthly from five healthy men, over 1 year. In these samples (N = 60), sperm count variability (43.1%, calculated in terms of the coefficient of variation), was similar to that of LDH‐X (40.4%) and higher than for transferrin (23.0%).</description><subject>Adult</subject><subject>azoospermia</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Isoenzymes</subject><subject>Kinetics</subject><subject>L-Lactate Dehydrogenase - analysis</subject><subject>LDH‐X</subject><subject>Male</subject><subject>Mammalian male genital system</subject><subject>Morphology. Physiology</subject><subject>Oligospermia - enzymology</subject><subject>Oligospermia - metabolism</subject><subject>oligozoospermia</subject><subject>Semen - analysis</subject><subject>Semen - enzymology</subject><subject>seminal biochemical parameters</subject><subject>Sertoli Cells - physiology</subject><subject>sperm count</subject><subject>transferrin</subject><subject>Transferrin - analysis</subject><subject>variability in semen characteristics</subject><subject>Vasectomy</subject><subject>Vertebrates: reproduction</subject><issn>0196-3635</issn><issn>1939-4640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1LwzAUhoMoc05_glBEvOs8p-nS1iuHX1Om3ih4F9ImdRn9mElL9d-bsjKvhUCS877vOYeHkDOEKQIEl-spJjTxQxa6QhLH0yYFBPf53iPjnbRPxoAJ8ymjs0NyZO3aZQEjOiIjGgJ19TFZPCthW6NKVTVenXtWlboShbe8Xfgfnqik1xhR2VwZoyvPnao2pdN7RVeu3OhCeS59TA5yUVh1MtwT8n5_93az8JevD48386WfhTGCnzEpEXI6wxSBIk0FoyCEnMkMAylpECVhmjKpFARRnEYiRAWzIE4Yy2TszBNyse27MfVXq2zDS20zVRSiUnVreRRTBhj2xqutMTO1tUblfGN0KcwPR-A9Rr7mPSves-I9Rj5g5N8ufDpMadNSyV104Ob080EXNhNF7hhl2u5sLEJIotDZrre2zlH6-ccC_Gn-cts__yat9Oeq00Zx6_gXbi_kXdclnPIgAPoLw6WbPw</recordid><startdate>198805</startdate><enddate>198805</enddate><creator>Orlando, C</creator><creator>Casano, R</creator><creator>Caldini, A. L</creator><creator>Forti, G</creator><creator>Barni, T</creator><creator>Bonfanti, L</creator><creator>Serio, M</creator><general>Am Soc Andrology</general><general>Blackwell Publishing Ltd</general><general>American Society of Andrology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198805</creationdate><title>Measurement of seminal LDH-X and transferrin in normal and infertile men</title><author>Orlando, C ; Casano, R ; Caldini, A. L ; Forti, G ; Barni, T ; Bonfanti, L ; Serio, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4810-c6dd10f351b10313ba630aad5dc12dd32794bb6dee0278b7a41e0528966cd8a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>azoospermia</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Isoenzymes</topic><topic>Kinetics</topic><topic>L-Lactate Dehydrogenase - analysis</topic><topic>LDH‐X</topic><topic>Male</topic><topic>Mammalian male genital system</topic><topic>Morphology. Physiology</topic><topic>Oligospermia - enzymology</topic><topic>Oligospermia - metabolism</topic><topic>oligozoospermia</topic><topic>Semen - analysis</topic><topic>Semen - enzymology</topic><topic>seminal biochemical parameters</topic><topic>Sertoli Cells - physiology</topic><topic>sperm count</topic><topic>transferrin</topic><topic>Transferrin - analysis</topic><topic>variability in semen characteristics</topic><topic>Vasectomy</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orlando, C</creatorcontrib><creatorcontrib>Casano, R</creatorcontrib><creatorcontrib>Caldini, A. L</creatorcontrib><creatorcontrib>Forti, G</creatorcontrib><creatorcontrib>Barni, T</creatorcontrib><creatorcontrib>Bonfanti, L</creatorcontrib><creatorcontrib>Serio, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of andrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orlando, C</au><au>Casano, R</au><au>Caldini, A. L</au><au>Forti, G</au><au>Barni, T</au><au>Bonfanti, L</au><au>Serio, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of seminal LDH-X and transferrin in normal and infertile men</atitle><jtitle>Journal of andrology</jtitle><addtitle>J Androl</addtitle><date>1988-05</date><risdate>1988</risdate><volume>9</volume><issue>3</issue><spage>220</spage><epage>223</epage><pages>220-223</pages><issn>0196-3635</issn><eissn>1939-4640</eissn><coden>JOAND3</coden><abstract>LDH‐X, an isoenzyme of lactate dehydrogenase specific for germinal epithelium activity, has been measured in the seminal plasma of infertile subjects whose infertility had different origins. In the same samples, seminal transferrin, an index of Sertoli cell function, was also measured. In this investigation, seminal LDH‐X was not detectable in the vasectomized subjects, in patients with azoospermia due to seminiferous tubular damage, nor in patients who showed a marked decrease in sperm concentration (<1 × 106/ml). In Oligozoospermic patients (sperm concentration < 20 × 106/ml) seminal LDH‐X levels were reduced to about one‐third of those found in normal controls. Seminal LDH‐X levels correlated (r = 0.7237) with total sperm count better than seminal transferrin levels (r = 0.5511), while no correlation was found between these two biochemical parameters and sperm motility, viability and morphology. To study their spontaneous variations with time, LDH‐X and transferrin were also measured in semen specimens collected monthly from five healthy men, over 1 year. In these samples (N = 60), sperm count variability (43.1%, calculated in terms of the coefficient of variation), was similar to that of LDH‐X (40.4%) and higher than for transferrin (23.0%).</abstract><cop>Oxford, UK</cop><pub>Am Soc Andrology</pub><pmid>3403363</pmid><doi>10.1002/j.1939-4640.1988.tb01040.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of andrology, 1988-05, Vol.9 (3), p.220-223 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult azoospermia Biological and medical sciences Fundamental and applied biological sciences. Psychology Humans Isoenzymes Kinetics L-Lactate Dehydrogenase - analysis LDH‐X Male Mammalian male genital system Morphology. Physiology Oligospermia - enzymology Oligospermia - metabolism oligozoospermia Semen - analysis Semen - enzymology seminal biochemical parameters Sertoli Cells - physiology sperm count transferrin Transferrin - analysis variability in semen characteristics Vasectomy Vertebrates: reproduction |
| title | Measurement of seminal LDH-X and transferrin in normal and infertile men |
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