Bioactive Metabolites of EM574 and EM523, Erythromycin Derivatives Having Strong Gastrointestinal Motor Stimulating Activity

Two motilides, EM574 (N-demethyl-N-isopropyl-8, 9-anhydroerythromycin A 6, 9-hemiacetal) and EM523 (N-demethyl-N-ethyl-8, 9-anhydroerythromycin A 6, 9-hemiacetal) have strong gastrointestinal motor stimulating (GMS) activity. When administered orally to dogs, these agents showed strong GMS activity,...

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Veröffentlicht in:	Journal of antibiotics 1996/08/25, Vol.49(8), pp.794-801
Hauptverfasser:	FUNABASHI, YASUNORI, MAESHIBA, YOSHIHIRO, INATOMI, NOBUHIRO, TANAYAMA, SHIGEHARU, HARADA, SETSUO, ITOH, ZEN, OMURA, SATOSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Digestive system Dogs Erythromycin - analogs & derivatives Erythromycin - metabolism Erythromycin - pharmacology Gastrointestinal Agents - pharmacology Gastrointestinal Motility - drug effects In Vitro Techniques Male Medical sciences Pharmacology. Drug treatments Rabbits
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