Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats
Freely feeding rats received an anorexigenic dose of dl-fenfluramine HCL(5 mg/kg). Two hours following injection, their stomachs retained significantly greater dry weight contents than saline-injected contrls. The same dose of fenfluramine decreased the rate of gastric emptying over a 2 h period to...
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| Veröffentlicht in: | European journal of pharmacology 1988-05, Vol.150 (1), p.137-142 |
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| container_title | European journal of pharmacology |
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| creator | Baker, Barbara J. Duggan, John P. Barber, David J. Booth, David A. |
| description | Freely feeding rats received an anorexigenic dose of dl-fenfluramine HCL(5 mg/kg). Two hours following injection, their stomachs retained significantly greater dry weight contents than saline-injected contrls. The same dose of fenfluramine decreased the rate of gastric emptying over a 2 h period to a similar extent in mildly food-deprived rats. The peripherally acting serotonin antagonist xylamidine counteracted the effect of fenfluramine in prolonging the satiating effect of an ad libitum meal of a given size. We propose therefore that the principal mechanism by which fenfluramine reduces food consumption in freely feeding rats is through a prolongation of the satiating effect of absorption as a result of slowing of gastric emptying, presumably via enhanced release of serotonin from nerve terminals in the wall of the gastrointestinal tract. |
| doi_str_mv | 10.1016/0014-2999(88)90759-5 |
| format | Article |
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Two hours following injection, their stomachs retained significantly greater dry weight contents than saline-injected contrls. The same dose of fenfluramine decreased the rate of gastric emptying over a 2 h period to a similar extent in mildly food-deprived rats. The peripherally acting serotonin antagonist xylamidine counteracted the effect of fenfluramine in prolonging the satiating effect of an ad libitum meal of a given size. We propose therefore that the principal mechanism by which fenfluramine reduces food consumption in freely feeding rats is through a prolongation of the satiating effect of absorption as a result of slowing of gastric emptying, presumably via enhanced release of serotonin from nerve terminals in the wall of the gastrointestinal tract.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(88)90759-5</identifier><identifier>PMID: 3402534</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amidines - pharmacology ; Animals ; Biological and medical sciences ; Diet ; Fenfluramine - pharmacology ; Fenfluramine anorexia ; Freely feeding rats ; Gastric emptying ; Gastric Emptying - drug effects ; Male ; Medical sciences ; Miscellaneous ; Neuropharmacology ; Pharmacology. 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Two hours following injection, their stomachs retained significantly greater dry weight contents than saline-injected contrls. The same dose of fenfluramine decreased the rate of gastric emptying over a 2 h period to a similar extent in mildly food-deprived rats. The peripherally acting serotonin antagonist xylamidine counteracted the effect of fenfluramine in prolonging the satiating effect of an ad libitum meal of a given size. We propose therefore that the principal mechanism by which fenfluramine reduces food consumption in freely feeding rats is through a prolongation of the satiating effect of absorption as a result of slowing of gastric emptying, presumably via enhanced release of serotonin from nerve terminals in the wall of the gastrointestinal tract.</description><subject>Amidines - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diet</subject><subject>Fenfluramine - pharmacology</subject><subject>Fenfluramine anorexia</subject><subject>Freely feeding rats</subject><subject>Gastric emptying</subject><subject>Gastric Emptying - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Satiety Response - physiology</subject><subject>Serotonin</subject><subject>Serotonin Antagonists - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1LBCEUhiWKbfv4BwVeRNTFlDqj49wEEdsHBN3Utbh6LGPG2XQ22n-f0y572ZUczvO-6CNCJ5RcUULFNSG0KljTNBdSXjak5k3Bd9CUyropSE3ZLppukX10kNInIYQ3jE_QpKwI42U1RR8z58AMCfcO27ZwEFy7jLrzAbAOFv-s2jzYcewDftdpiN5g6BbDyof3MdVpHwYIOhjA1sOAfcAuArQr7ADsSEU9pCO053Sb4HhzHqK3-9nr3WPx_PLwdHf7XJiKs6EoxVxqzipmtDDCOMeoqy3Ljyp5bTnhNRWaG24sqeZlabV1QjBhpaEcgLjyEJ2vexex_1pCGlTnk4G21QH6ZVK1zEXZTgarNWhin1IEpxbRdzquFCVqFKxGe2q0p6RUf4IVz7HTTf9y3oHdhjZG8_5ss9fJ6NbFLManLVZT2hAhM3azxiC7-PYQVTIeskPrY_4PZXv__z1-AbDtl-U</recordid><startdate>19880520</startdate><enddate>19880520</enddate><creator>Baker, Barbara J.</creator><creator>Duggan, John P.</creator><creator>Barber, David J.</creator><creator>Booth, David A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880520</creationdate><title>Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats</title><author>Baker, Barbara J. ; Duggan, John P. ; Barber, David J. ; Booth, David A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-36b8a5242ca6c6cff21f7d2187357d505716a5c5cd04b33dadf6626d8c15ee0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amidines - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diet</topic><topic>Fenfluramine - pharmacology</topic><topic>Fenfluramine anorexia</topic><topic>Freely feeding rats</topic><topic>Gastric emptying</topic><topic>Gastric Emptying - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Satiety Response - physiology</topic><topic>Serotonin</topic><topic>Serotonin Antagonists - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baker, Barbara J.</creatorcontrib><creatorcontrib>Duggan, John P.</creatorcontrib><creatorcontrib>Barber, David J.</creatorcontrib><creatorcontrib>Booth, David A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baker, Barbara J.</au><au>Duggan, John P.</au><au>Barber, David J.</au><au>Booth, David A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1988-05-20</date><risdate>1988</risdate><volume>150</volume><issue>1</issue><spage>137</spage><epage>142</epage><pages>137-142</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Freely feeding rats received an anorexigenic dose of dl-fenfluramine HCL(5 mg/kg). Two hours following injection, their stomachs retained significantly greater dry weight contents than saline-injected contrls. The same dose of fenfluramine decreased the rate of gastric emptying over a 2 h period to a similar extent in mildly food-deprived rats. The peripherally acting serotonin antagonist xylamidine counteracted the effect of fenfluramine in prolonging the satiating effect of an ad libitum meal of a given size. We propose therefore that the principal mechanism by which fenfluramine reduces food consumption in freely feeding rats is through a prolongation of the satiating effect of absorption as a result of slowing of gastric emptying, presumably via enhanced release of serotonin from nerve terminals in the wall of the gastrointestinal tract.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>3402534</pmid><doi>10.1016/0014-2999(88)90759-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1988-05, Vol.150 (1), p.137-142 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amidines - pharmacology Animals Biological and medical sciences Diet Fenfluramine - pharmacology Fenfluramine anorexia Freely feeding rats Gastric emptying Gastric Emptying - drug effects Male Medical sciences Miscellaneous Neuropharmacology Pharmacology. Drug treatments Rats Satiety Response - physiology Serotonin Serotonin Antagonists - pharmacology |
| title | Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats |
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