Aqueous Stability of Recombinant Human Thrombopoietin as a Function of Processing Schemes

Preformulation studies conducted with recombinant human thrombopoietin (rhTPO), a 332 amino acid glycoprotein which stimulates platelet production, show distinctions in degradation profiles as a function of processing schemes. The stability-limiting degradation pathways change as a function of purif...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1996-07, Vol.85 (7), p.749-752
Hauptverfasser:	Senderoff, Richard I., Kontor, Kathleen M., Heffernan, Jane K., Clarke, Holly J., Garrison, Lori K., Kreilgaard, Lotte, Lasser, Gerald W., Rosenberg, Gary B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cell Line Cricetinae Drug Stability Electrophoresis, Polyacrylamide Gel Humans Medical sciences Pharmacology. Drug treatments Recombinant Proteins - chemistry Thrombopoietin - chemistry
Online-Zugang:	Volltext
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