Temperature-dependent Block of Capacitative Ca2+ Influx in the Human Leukemic Cell Line KU-812

The mechanism by which depletion of intracellular Ca 2+ stores activates Ca 2+ influx is not understood. We recently showed that primaquine, an inhibitor of vesicular transport, blocks the activation of the calcium release-activated calcium current ( I CRAC ) in rat megakaryocytes (Somasundaram, B.,...

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Veröffentlicht in:	The Journal of biological chemistry 1996-10, Vol.271 (42), p.26096-26104
Hauptverfasser:	Somasundaram, B, Mahaut-Smith, M P, Floto, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Calcium - metabolism Calcium Channels - drug effects Calcium Channels - metabolism Cytosol - metabolism Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Fluorescent Dyes - metabolism Fura-2 - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Humans Leukemia Manganese - metabolism Patch-Clamp Techniques Potassium - metabolism Primaquine - pharmacology Sodium - metabolism Temperature Thapsigargin - pharmacology Tumor Cells, Cultured
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