Physiological stresses inhibit guanine‐nucleotide‐exchange factor in Ehrlich cells

Previously, we have shown that phosphorylation of the eukaryotic initiation factor eIF‐2α increases under several physiological stresses in which protein synthesis is inhibited in Ehrlich ascites tumor cells. As phosphorylated eIF‐2 [eIF‐2(αP)] is a potent inhibitor of guanine nucleotide exchange fa...

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Veröffentlicht in:	European journal of biochemistry 1988-07, Vol.175 (1), p.93-99
Hauptverfasser:	ROWLANDS, Anne G., MONTINE, Kathleen S., HENSHAW, Edgar C., PANNIERS, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Ehrlich Tumor - metabolism Eukaryotic Initiation Factor-2 Glutamine - metabolism Guanine Nucleotide Exchange Factors Guanosine Diphosphate - metabolism Peptide Initiation Factors - metabolism Proteins - antagonists & inhibitors Proteins - metabolism Rabbits Temperature
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