Influence of renal function on the elimination of morphine and morphine glucuronides
The influence of renal function, measured by 51Cr-EDTA clearance, on morphine and morphine glucuronide kinetics has been studied in 13 patients after a single i.v. injection of morphine. Unconjugated morphine and morphine glucuronides were measured by a sensitive, specific RIA after extraction from...
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| Veröffentlicht in: | European journal of clinical pharmacology 1988-01, Vol.34 (4), p.353-357 |
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| container_end_page | 357 |
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| container_issue | 4 |
| container_start_page | 353 |
| container_title | European journal of clinical pharmacology |
| container_volume | 34 |
| creator | WOLFF, J BIGLER, D BROEN CHRISTENSEN, C RASMUSSEN, S. N ANDERSEN, H. B TØNNESEN, K. H |
| description | The influence of renal function, measured by 51Cr-EDTA clearance, on morphine and morphine glucuronide kinetics has been studied in 13 patients after a single i.v. injection of morphine. Unconjugated morphine and morphine glucuronides were measured by a sensitive, specific RIA after extraction from plasma. No significant correlation was found between total body clearance of unconjugated morphine and 51Cr-EDTA clearance. However, patients with renal insufficiency had impaired elimination of morphine glucuronides, and the apparent clearance was significantly correlated with the 51Cr-EDTA clearance (r = 0.94, p less than 0.001). A relatively long terminal elimination of half-life of morphine was found in all patients (mean +/- SD: 9.2 +/- 2.5 h), irrespective of glomerular function. |
| doi_str_mv | 10.1007/BF00542435 |
| format | Article |
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A relatively long terminal elimination of half-life of morphine was found in all patients (mean +/- SD: 9.2 +/- 2.5 h), irrespective of glomerular function.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00542435</identifier><identifier>PMID: 3402521</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aged ; Aged, 80 and over ; Analgesics ; Biological and medical sciences ; Female ; Glomerular Filtration Rate ; Glucuronates - metabolism ; Humans ; Kidney Diseases - metabolism ; Male ; Medical sciences ; Middle Aged ; Morphine - blood ; Morphine - metabolism ; Morphine - pharmacokinetics ; Neuropharmacology ; Pharmacology. 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N</creatorcontrib><creatorcontrib>ANDERSEN, H. B</creatorcontrib><creatorcontrib>TØNNESEN, K. H</creatorcontrib><title>Influence of renal function on the elimination of morphine and morphine glucuronides</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>The influence of renal function, measured by 51Cr-EDTA clearance, on morphine and morphine glucuronide kinetics has been studied in 13 patients after a single i.v. injection of morphine. Unconjugated morphine and morphine glucuronides were measured by a sensitive, specific RIA after extraction from plasma. No significant correlation was found between total body clearance of unconjugated morphine and 51Cr-EDTA clearance. However, patients with renal insufficiency had impaired elimination of morphine glucuronides, and the apparent clearance was significantly correlated with the 51Cr-EDTA clearance (r = 0.94, p less than 0.001). A relatively long terminal elimination of half-life of morphine was found in all patients (mean +/- SD: 9.2 +/- 2.5 h), irrespective of glomerular function.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Glucuronates - metabolism</subject><subject>Humans</subject><subject>Kidney Diseases - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morphine - blood</subject><subject>Morphine - metabolism</subject><subject>Morphine - pharmacokinetics</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WOLFF, J</creatorcontrib><creatorcontrib>BIGLER, D</creatorcontrib><creatorcontrib>BROEN CHRISTENSEN, C</creatorcontrib><creatorcontrib>RASMUSSEN, S. N</creatorcontrib><creatorcontrib>ANDERSEN, H. B</creatorcontrib><creatorcontrib>TØNNESEN, K. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WOLFF, J</au><au>BIGLER, D</au><au>BROEN CHRISTENSEN, C</au><au>RASMUSSEN, S. N</au><au>ANDERSEN, H. B</au><au>TØNNESEN, K. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of renal function on the elimination of morphine and morphine glucuronides</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1988-01-01</date><risdate>1988</risdate><volume>34</volume><issue>4</issue><spage>353</spage><epage>357</epage><pages>353-357</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>The influence of renal function, measured by 51Cr-EDTA clearance, on morphine and morphine glucuronide kinetics has been studied in 13 patients after a single i.v. injection of morphine. Unconjugated morphine and morphine glucuronides were measured by a sensitive, specific RIA after extraction from plasma. No significant correlation was found between total body clearance of unconjugated morphine and 51Cr-EDTA clearance. However, patients with renal insufficiency had impaired elimination of morphine glucuronides, and the apparent clearance was significantly correlated with the 51Cr-EDTA clearance (r = 0.94, p less than 0.001). A relatively long terminal elimination of half-life of morphine was found in all patients (mean +/- SD: 9.2 +/- 2.5 h), irrespective of glomerular function.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>3402521</pmid><doi>10.1007/BF00542435</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of clinical pharmacology, 1988-01, Vol.34 (4), p.353-357 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Aged, 80 and over Analgesics Biological and medical sciences Female Glomerular Filtration Rate Glucuronates - metabolism Humans Kidney Diseases - metabolism Male Medical sciences Middle Aged Morphine - blood Morphine - metabolism Morphine - pharmacokinetics Neuropharmacology Pharmacology. Drug treatments |
| title | Influence of renal function on the elimination of morphine and morphine glucuronides |
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