Dopaminergic system and monoamine oxidase-B Activity in Alzheimer's disease

The possible involvement of dopaminergic neurons in dementia of Alzheimer type (AD/SDAT) was studied in autopsied brains from 20 patients with AD/SDAT. Dopamine (DA) concentrations were decreased significantly in the temporal cortex, hippocampul cortex and hippocampus in AD/SDAT patients. Levels of...

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Veröffentlicht in:	Neurobiology of aging 1988-05, Vol.9 (3), p.245-252
Hauptverfasser:	Reinikainen, Kari J., Paljarvi, Leo, Halonen, Toivo, Malminen, Outi, Kosma, Veli-Matti, Laakso, Markku, Riekkinen, Paavo J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - enzymology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Brain - enzymology Brain - metabolism Brain - pathology Cerebrospinal fluid (CSF) Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine Dopamine - metabolism Female Homovanillic acid Homovanillic Acid - analysis Homovanillic Acid - cerebrospinal fluid Humans Male Medical sciences Monoamine Oxidase - metabolism Monoamine oxidase-B Neurology Parkinsonian pathology Post-mortem brain
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