Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle

Phosphodiesterase isozymes were isolated by diethylaminoethyl ether (DEAE) column chromatography from cardiac muscle (canine, guinea pig), vascular (canine and guinea pig aortic) and airway (canine tracheal) smooth muscle. All peak I phosphodiesterases had a low apparent K m (0.29–0.49 μM) for guano...

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Veröffentlicht in:	European journal of pharmacology 1988-05, Vol.150 (1), p.85-94
Hauptverfasser:	Silver, Paul J., Hamel, Linda T., Perrone, Mark H., Bentley, Ross G., Bushover, Cynthia R., Evans, Dale B.
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors Animals Aorta, Thoracic - drug effects Aorta, Thoracic - enzymology Biological and medical sciences Cardiac muscle Cardiotonic agents Cardiovascular system Chromatography, DEAE-Cellulose Dogs Guinea Pigs In Vitro Techniques Isoenzymes - antagonists & inhibitors Medical sciences Muscle, Smooth - enzymology Muscle, Smooth, Vascular - enzymology Myocardium - enzymology Pharmacology. Drug treatments Phosphodiesterase isozymes Smooth muscle (tracheal) Smooth muscle (vascular)
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