Rat cardiac hypertrophy Altered sodium-calcium exchange activity in sarcolemmal vesicles

The sodium-calcium exchange activity has been studied in sarcolemmal vesicles isolated from rat ventricles hypertrophied by pressure overload. 4 weeks after aortic stenosis the degree of hypertrophy varied from 30 to 70%. The Na +-dependent 45Ca 2+ influx and efflux were up to 50% decreased and the...

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Veröffentlicht in:	FEBS letters 1988-08, Vol.236 (1), p.145-149
Hauptverfasser:	Hanf, Remy, Drubaix, Isabelle, Marotte, Françoise, Lelievre, Lionel G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences calcium Calcium - metabolism Cardiology. Vascular system Cardiomegaly - metabolism Cell Membrane - metabolism Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hypertrophy Male Medical sciences Membrane Potentials Microsomes - metabolism Microsomes - ultrastructure Mitochondria, Heart - metabolism Mitochondria, Heart - ultrastructure Myocardium - metabolism Na +/Ca 2+ exchange Na+/Ca2+ exchange Rat myocardium Rats Rats, Inbred Strains Sarcolemma Sarcolemma - metabolism sodium Sodium - metabolism
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