A Gene for Non-Syndromic Autosomal Dominant Progressive Postlingual Sensorineural Hearing Loss Maps to Chromosome 14q12–13

We report a novel locus responsible for postlingual progressive sensorineural hearing loss (designated DFNA9) that maps to chromosome 14q12–13. A large kindred with autosomal dominant transmission of non-syndromic hearing loss was clinically studied. Hearing in affected individuals deteriorated at ∼...

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Veröffentlicht in:	Human molecular genetics 1996-07, Vol.5 (7), p.1047-1050
Hauptverfasser:	Manolis, Evangelos N., Yandavi, Naidu, Nadol, Joseph B., Eavey, Roland D., McKenna, Michael, Rosenbaum, Stella, Khetarpal, Uman, Halpin, Christopher, Merchant, Saumil N., Duyk, Geoffrey M., MacRae, Calum, Seidman, Christine E., Seidman, J.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Biological and medical sciences Cell Line Chromosome Mapping Chromosomes, Human, Pair 14 - genetics Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Female Genes, Dominant - genetics Haplotypes Hearing Loss, Sensorineural - genetics Hearing Loss, Sensorineural - physiopathology Humans Lod Score Lymphocytes Male Medical sciences Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Pedigree
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