Cytokine Control of Interstitial Collagenase and Collagenase-3 Gene Expression in Human Chondrocytes

Human collagenase-3 expression, previously seen only in a breast tumor tissue, is here shown to be expressed in primary human chondrocytes derived from the joint tissue and in transformed human chondrocytes. Its mRNA is inducible by the inflammatory cytokines interleukin-1Î² plus tumor necrosis fact...

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Veröffentlicht in:	The Journal of biological chemistry 1996-09, Vol.271 (38), p.23577-23581
Hauptverfasser:	Borden, P, Solymar, D, Sucharczuk, A, Lindman, B, Cannon, P, Heller, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cartilage - cytology Cartilage - drug effects Cartilage - physiology Cells, Cultured Collagenases - biosynthesis Collagenases - genetics Cytokines - pharmacology Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Regulation, Enzymologic Humans Interleukin-1 - pharmacology Matrix Metalloproteinase 1 Matrix Metalloproteinase 13 Mice Promoter Regions, Genetic Proto-Oncogene Proteins c-fos - metabolism Recombinant Proteins - biosynthesis RNA, Messenger - analysis Synovial Membrane - cytology Synovial Membrane - metabolism Transcription Factor AP-1 Transcription Factors - metabolism Tumor Necrosis Factor-alpha - pharmacology
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