Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

Muscarinic acetylcholine receptors (mAChRs), like many other neurotransmitter and hormone receptors, transduce agonist signals by activating G proteins to regulate ion channel activity and the generation of second messengers via the phosphoinositide (PI) and adenylyl cyclase systems. Human mAChRs ar...

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Veröffentlicht in:	Nature (London) 1988-08, Vol.334 (6181), p.434-437
Hauptverfasser:	PERALTA, E. G, ASHKENAZI, A, WINSLOW, J. W, RAMACHANDRAN, J, CAPON, D. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Biochemistry Biological and medical sciences Carbachol - pharmacology Cell Line Cell receptors Cell structures and functions Cellular biology Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology Humans Hydrolysis Medical research Molecular and cellular biology Molecules Phosphatidylinositols - metabolism Receptors, Muscarinic - metabolism Time Factors
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