Regional cerebral blood flow in patients with schizophrenia : Relevance to symptom structures
Regional cerebral blood flow (rCBF) was measured with technetium-99m hexamethylpropyleneamine oxime single photon emission computed tomography in 38 neuroleptic-treated schizophrenic patients. To improve the validity of the evaluation of symptomatology, we applied findings previously derived in a pr...
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| Veröffentlicht in: | Psychiatry research 1996-05, Vol.67 (1), p.49-58 |
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| container_title | Psychiatry research |
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| creator | KAWASAKI, Y MAEDA, Y SAKAI, N HIGASHIMA, M YAMAGUCHI, N KOSHINO, Y HISADA, K SUZUKI, M MATSUDA, H |
| description | Regional cerebral blood flow (rCBF) was measured with technetium-99m hexamethylpropyleneamine oxime single photon emission computed tomography in 38 neuroleptic-treated schizophrenic patients. To improve the validity of the evaluation of symptomatology, we applied findings previously derived in a principal component analysis (PCA) of the Positive and Negative Syndrome Scale. The PCA had disclosed five orthogonal independent symptom structures (i.e., negative, hostile/excited, thought disordered, delusional/hallucinatory, and depressive components), and obtained factor scores for 70 schizophrenic subjects, including the present sample. Stepwise regression analysis elucidated some of the cortical regions in which relative rCBF predicted the severity of symptoms--namely, lateral and orbital prefrontal, lateral temporal, inferior parietal, and medial temporal regions. Findings suggested that symptom structures derived from PCA could prove helpful in elucidating the pathophysiology of neural mechanisms. |
| doi_str_mv | 10.1016/0925-4927(96)02685-6 |
| format | Article |
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To improve the validity of the evaluation of symptomatology, we applied findings previously derived in a principal component analysis (PCA) of the Positive and Negative Syndrome Scale. The PCA had disclosed five orthogonal independent symptom structures (i.e., negative, hostile/excited, thought disordered, delusional/hallucinatory, and depressive components), and obtained factor scores for 70 schizophrenic subjects, including the present sample. Stepwise regression analysis elucidated some of the cortical regions in which relative rCBF predicted the severity of symptoms--namely, lateral and orbital prefrontal, lateral temporal, inferior parietal, and medial temporal regions. Findings suggested that symptom structures derived from PCA could prove helpful in elucidating the pathophysiology of neural mechanisms.</description><identifier>ISSN: 0165-1781</identifier><identifier>DOI: 10.1016/0925-4927(96)02685-6</identifier><identifier>PMID: 8797242</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Delusions - psychology ; Female ; Functional Laterality ; Hallucinations - psychology ; Humans ; Male ; Medical sciences ; Middle Aged ; Prefrontal Cortex - blood supply ; Prefrontal Cortex - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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To improve the validity of the evaluation of symptomatology, we applied findings previously derived in a principal component analysis (PCA) of the Positive and Negative Syndrome Scale. The PCA had disclosed five orthogonal independent symptom structures (i.e., negative, hostile/excited, thought disordered, delusional/hallucinatory, and depressive components), and obtained factor scores for 70 schizophrenic subjects, including the present sample. Stepwise regression analysis elucidated some of the cortical regions in which relative rCBF predicted the severity of symptoms--namely, lateral and orbital prefrontal, lateral temporal, inferior parietal, and medial temporal regions. Findings suggested that symptom structures derived from PCA could prove helpful in elucidating the pathophysiology of neural mechanisms.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Delusions - psychology</subject><subject>Female</subject><subject>Functional Laterality</subject><subject>Hallucinations - psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prefrontal Cortex - blood supply</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Regional Blood Flow</subject><subject>Schizophrenia</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Temporal Lobe - blood supply</subject><subject>Temporal Lobe - physiopathology</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>0165-1781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhbNQxvHxDxSyENFFNUnTPNzJ4AsGhGG2UtI0cSJpU5PUYfz1FhxcnQvfx4VzADjH6BYjzO6QJFVBJeHXkt0gwkRVsAMwn1BVYC7wEThO6RMhRLCUMzATXHJCyRy8r8yHC73yUJtomjgdjQ-hhdaHLXQ9HFR2ps8Jbl3ewKQ37icMm2h6p-A9XBlvvlWvDcwBpl035NDBlOOo8xhNOgWHVvlkzvZ5AtZPj-vFS7F8e35dPCyLgZRVLmzVUoaEtEQ1DWuJoVSX2lJEdUsQl02LkGJYcmlxw_TUQVmBWi1LykmpyxNw9fd2iOFrNCnXnUvaeK96E8ZUczGJpUCTeLEXx6YzbT1E16m4q_dzTPxyz1XSyts4VXPpXyNESiRE-Qu9Zm6L</recordid><startdate>19960531</startdate><enddate>19960531</enddate><creator>KAWASAKI, Y</creator><creator>MAEDA, Y</creator><creator>SAKAI, N</creator><creator>HIGASHIMA, M</creator><creator>YAMAGUCHI, N</creator><creator>KOSHINO, Y</creator><creator>HISADA, K</creator><creator>SUZUKI, M</creator><creator>MATSUDA, H</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19960531</creationdate><title>Regional cerebral blood flow in patients with schizophrenia : Relevance to symptom structures</title><author>KAWASAKI, Y ; MAEDA, Y ; SAKAI, N ; HIGASHIMA, M ; YAMAGUCHI, N ; KOSHINO, Y ; HISADA, K ; SUZUKI, M ; MATSUDA, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-f5d46089f2abb6d2e44c3cf404cd2079bd00a61979f1b6c219af80dc934723c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Delusions - psychology</topic><topic>Female</topic><topic>Functional Laterality</topic><topic>Hallucinations - psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prefrontal Cortex - blood supply</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Regional Blood Flow</topic><topic>Schizophrenia</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Temporal Lobe - blood supply</topic><topic>Temporal Lobe - physiopathology</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAWASAKI, Y</creatorcontrib><creatorcontrib>MAEDA, Y</creatorcontrib><creatorcontrib>SAKAI, N</creatorcontrib><creatorcontrib>HIGASHIMA, M</creatorcontrib><creatorcontrib>YAMAGUCHI, N</creatorcontrib><creatorcontrib>KOSHINO, Y</creatorcontrib><creatorcontrib>HISADA, K</creatorcontrib><creatorcontrib>SUZUKI, M</creatorcontrib><creatorcontrib>MATSUDA, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAWASAKI, Y</au><au>MAEDA, Y</au><au>SAKAI, N</au><au>HIGASHIMA, M</au><au>YAMAGUCHI, N</au><au>KOSHINO, Y</au><au>HISADA, K</au><au>SUZUKI, M</au><au>MATSUDA, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional cerebral blood flow in patients with schizophrenia : Relevance to symptom structures</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1996-05-31</date><risdate>1996</risdate><volume>67</volume><issue>1</issue><spage>49</spage><epage>58</epage><pages>49-58</pages><issn>0165-1781</issn><coden>PSRSDR</coden><abstract>Regional cerebral blood flow (rCBF) was measured with technetium-99m hexamethylpropyleneamine oxime single photon emission computed tomography in 38 neuroleptic-treated schizophrenic patients. To improve the validity of the evaluation of symptomatology, we applied findings previously derived in a principal component analysis (PCA) of the Positive and Negative Syndrome Scale. The PCA had disclosed five orthogonal independent symptom structures (i.e., negative, hostile/excited, thought disordered, delusional/hallucinatory, and depressive components), and obtained factor scores for 70 schizophrenic subjects, including the present sample. Stepwise regression analysis elucidated some of the cortical regions in which relative rCBF predicted the severity of symptoms--namely, lateral and orbital prefrontal, lateral temporal, inferior parietal, and medial temporal regions. Findings suggested that symptom structures derived from PCA could prove helpful in elucidating the pathophysiology of neural mechanisms.</abstract><cop>Shannon</cop><pub>Elsevier</pub><pmid>8797242</pmid><doi>10.1016/0925-4927(96)02685-6</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Delusions - psychology Female Functional Laterality Hallucinations - psychology Humans Male Medical sciences Middle Aged Prefrontal Cortex - blood supply Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Regional Blood Flow Schizophrenia Schizophrenia - physiopathology Schizophrenic Psychology Temporal Lobe - blood supply Temporal Lobe - physiopathology Tomography, Emission-Computed, Single-Photon - methods |
| title | Regional cerebral blood flow in patients with schizophrenia : Relevance to symptom structures |
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