GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat

Neurons of the nucleus raphe magnus (NRM) and nucleus reticularis gigantocellularis pars alpha (NGCpα) have been implicated in the regulation of nociceptive threshold and production of antinociception. Previous studies have shown that the activity of these neurons is modulated by noradrenergic, chol...

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Veröffentlicht in:	Brain research 1988-05, Vol.450 (1), p.316-324
Hauptverfasser:	Drower, Edward J., Hammond, Donna L.
Format:	Artikel
Sprache:	eng
Schlagworte:	4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol Animals Antinociception Bicuculline Bicuculline - analogs & derivatives Bicuculline - pharmacology Biological and medical sciences Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - physiology Hyperalgesia Isoxazoles - pharmacology Male Medulla Oblongata - drug effects Medulla Oblongata - physiology Microinjections Nucleus raphe magnus Nucleus reticularis gigantocellularis pars alpha Oxazoles - pharmacology Pain - physiopathology Raphe Nuclei - drug effects Raphe Nuclei - physiology Rats Rats, Inbred Strains Reaction Time - drug effects Sensory Thresholds - drug effects Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs γ-Aminobutyric acid
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