Long-term oral ciprofloxacin: Experience in the treatment of incurable infective endocarditis
Acute septic infective endocarditis caused by Pseudomonas aeruginosa, in two patients with conditions that made it incurable, was treated with long-term orally administered ciprofloxacin. Bacteremia and symptoms cleared, resulting in subjective well-being without cure for three and one half and 22 m...
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| Veröffentlicht in: | The American journal of medicine 1988-04, Vol.84 (4), p.786-790 |
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| container_end_page | 790 |
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| container_issue | 4 |
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| container_title | The American journal of medicine |
| container_volume | 84 |
| creator | Daikos, George L. Kathpalia, Shashi B. Lolans, Valentina T. Jackson, George Gee Fosslien, Egil |
| description | Acute septic infective endocarditis caused by Pseudomonas aeruginosa, in two patients with conditions that made it incurable, was treated with long-term orally administered ciprofloxacin. Bacteremia and symptoms cleared, resulting in subjective well-being without cure for three and one half and 22 months, respectively. Large amounts of ciprofloxacin, 150 and 1,440 g, respectively, were given continuously without apparent adverse reactions. Blood isolates of P. aeruginosa after treatment had limited progression of resistance to ciprofloxacin. Use of orally administered ciprofloxacin provides new opportunities for the long-term treatment of serious infections with restricted risk of bacterial drug resistance and no appreciable side effects. |
| doi_str_mv | 10.1016/0002-9343(88)90122-2 |
| format | Article |
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Bacteremia and symptoms cleared, resulting in subjective well-being without cure for three and one half and 22 months, respectively. Large amounts of ciprofloxacin, 150 and 1,440 g, respectively, were given continuously without apparent adverse reactions. Blood isolates of P. aeruginosa after treatment had limited progression of resistance to ciprofloxacin. Use of orally administered ciprofloxacin provides new opportunities for the long-term treatment of serious infections with restricted risk of bacterial drug resistance and no appreciable side effects.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Ciprofloxacin - administration & dosage</subject><subject>Ciprofloxacin - therapeutic use</subject><subject>Drug Administration Schedule</subject><subject>Endocarditis, Bacterial - drug therapy</subject><subject>Heart Diseases - etiology</subject><subject>Heart Valve Diseases - complications</subject><subject>Heart Valve Diseases - drug therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas Infections - drug therapy</subject><subject>Sepsis - drug therapy</subject><subject>Thrombosis - etiology</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rVDEUhoModaz-gwp3IaKLq_lObhcFKfUDBrqpSwm5yUmN3HszTTKl_nsznWGWdRVO3uccDs9B6IzgTwQT-RljTPuBcfZB648DJpT29BlaESFEr4ikz9HqiLxEr0r500o8CHmCThhhQnG5Qr_WabntK-S5S9lOnYubnMKUHqyLy3l39bCBHGFx0MWlq7-hqxlsnWGpXQrtz22zHaddGsDVeA8dLD45m32ssbxGL4KdCrw5vKfo59erm8vv_fr624_LL-vecaJqL5nEHPSISWAjDVaFcSTUe0mZsFjxwVopg1DgtectFHTgWA9eEUe4oIKdovf7uW35uy2UauZYHEyTXSBti1GacSEH_l-QCK6l5KSBfA-6nErJEMwmx9nmv4Zgs9Nvdm7Nzq3R2jzqN7S1vT3M344z-GPTwXfL3x1yW5ydQraLi-WIKaJJO1DDLvYYNGn3EbIp7vEKPuam2fgUn97jH2OwoL4</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>Daikos, George L.</creator><creator>Kathpalia, Shashi B.</creator><creator>Lolans, Valentina T.</creator><creator>Jackson, George Gee</creator><creator>Fosslien, Egil</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19880401</creationdate><title>Long-term oral ciprofloxacin: Experience in the treatment of incurable infective endocarditis</title><author>Daikos, George L. ; Kathpalia, Shashi B. ; Lolans, Valentina T. ; Jackson, George Gee ; Fosslien, Egil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-63604e8b01f3b2fa7fbb12dd6235a0749aa66f57ed8d47fb5294089d71c145253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Ciprofloxacin - administration & dosage</topic><topic>Ciprofloxacin - therapeutic use</topic><topic>Drug Administration Schedule</topic><topic>Endocarditis, Bacterial - drug therapy</topic><topic>Heart Diseases - etiology</topic><topic>Heart Valve Diseases - complications</topic><topic>Heart Valve Diseases - drug therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. 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Bacteremia and symptoms cleared, resulting in subjective well-being without cure for three and one half and 22 months, respectively. Large amounts of ciprofloxacin, 150 and 1,440 g, respectively, were given continuously without apparent adverse reactions. Blood isolates of P. aeruginosa after treatment had limited progression of resistance to ciprofloxacin. Use of orally administered ciprofloxacin provides new opportunities for the long-term treatment of serious infections with restricted risk of bacterial drug resistance and no appreciable side effects.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3135746</pmid><doi>10.1016/0002-9343(88)90122-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9343 |
| ispartof | The American journal of medicine, 1988-04, Vol.84 (4), p.786-790 |
| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Administration, Oral Adult Aged Aged, 80 and over Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ciprofloxacin - administration & dosage Ciprofloxacin - therapeutic use Drug Administration Schedule Endocarditis, Bacterial - drug therapy Heart Diseases - etiology Heart Valve Diseases - complications Heart Valve Diseases - drug therapy Humans Male Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas Infections - drug therapy Sepsis - drug therapy Thrombosis - etiology |
| title | Long-term oral ciprofloxacin: Experience in the treatment of incurable infective endocarditis |
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