Evidence that Th1 Lymphocytes Predominate in Islet Inflammation and Thyroiditis in the BioBreeding (BB) Rat

Th1 cytokines are thought to play a key role in islet inflammation and destruction in insulin-dependent diabetes mellitus (IDDM). We studied this hypothesis in the diabetes-prone (DP)-BB and the diabetes-resistant (DR)-BB rats that are used as a model of human IDDM. The DP-BB rat develops spontaneou...

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Veröffentlicht in:	Journal of autoimmunity 1996-06, Vol.9 (3), p.315-319
1. Verfasser:	Zipris, Danny
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals autoimmune diabetes BB rat cytokines Cytokines - genetics Diabetes Mellitus, Type 1 Gene Expression islets Islets of Langerhans - pathology Pancreatitis - pathology Polymerase Chain Reaction - methods Rats Rats, Inbred BB - immunology RNA, Messenger - analysis T lymphocytes Th1 Cells - chemistry Th1 Cells - pathology Th2 Cells - chemistry Th2 Cells - cytology Th2 Cells - pathology thyroiditis Thyroiditis - pathology
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