Glial and muscle embryonal carcinoma cell-specific independent regulation of expression of human JC virus early promoter by cyclic AMP response elements and adjacent nuclear factor 1 binding sites

The human polyoma JC virus (JCV) is a glial cell‐specific virus and is the etiological agent for the terminal AIDS‐associated brain disease, progressive multifocal leukoencephalopathy (PML). JCV contains several binding sites for transcriptional factors that are important for activity in glial cells...

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Veröffentlicht in:	Journal of medical virology 1996-07, Vol.49 (3), p.199-204
Hauptverfasser:	Kumar, Kotlo U., Tang, Shou-Ching, Pater, Mary M., Pater, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Colforsin - pharmacology Cyclic AMP - pharmacology DNA, Viral DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonal Carcinoma Stem Cells Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Viral glial cell specificity Humans JC virus JC Virus - genetics Microbiology Neoplastic Stem Cells - cytology Neuroglia neurotropic NFI Transcription Factors Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Transcription Factors - genetics Transcription Factors - metabolism transcription regulation Tumor Cells, Cultured Virology
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