Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development

We have constructed cDNA clones covering the entire coding region of mouse, human and rabbit preprocathepsin K mRNA for studies on bone turnover. The clone pMCatK-1 for mouse cathepsin K shares 87% nucleotide homology with the corresponding human and rabbit sequences. Analysis of a panel of mouse ti...

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Veröffentlicht in:	FEBS letters 1996-09, Vol.393 (2), p.307-313
Hauptverfasser:	Rantakokko, Juho, Aro, Hannu T., Savontaus, Mikko, Vuorio, Eero
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Amino Acid Sequence Animals Base Sequence Bone Bone Development Cartilage Cartilage - growth & development Cartilage - metabolism Cartilage - pathology Cathepsin Cathepsin K Cathepsins - biosynthesis Cathepsins - chemistry Cloning, Molecular Coloring Agents DNA Primers DNA, Complementary Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Growth Plate - growth & development Growth Plate - metabolism Humans In Situ Hybridization Mice Molecular Sequence Data Mouse mRNA Organ Specificity Osteoclast Osteoclasts - enzymology Polymerase Chain Reaction Rabbits RNA Probes RNA, Messenger - biosynthesis Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Transcription, Genetic
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