Pharmacokinetics of oxcarbazepine and 10-hydroxy-carbazepine in the newborn child of an oxcarbazepine-treated mother
Gaschromatography--mass spectrometry (GC/MS) was used to determine plasma levels of oxcarbazepine (OCB) and its main metabolite in a newborn girl and her OCB-treated mother during the first five post partum days. At delivery the maternal and neonatal plasma concentrations were in the same range, ind...
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| Veröffentlicht in: | European journal of clinical pharmacology 1988-01, Vol.34 (3), p.311-313 |
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| container_end_page | 313 |
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| container_title | European journal of clinical pharmacology |
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| creator | BÜLAU, P PAAR, W. D VON UNRUH, G. E |
| description | Gaschromatography--mass spectrometry (GC/MS) was used to determine plasma levels of oxcarbazepine (OCB) and its main metabolite in a newborn girl and her OCB-treated mother during the first five post partum days. At delivery the maternal and neonatal plasma concentrations were in the same range, indicating considerable placental transfer of both substances. In spite of ingestion of both substances via breast milk, there was no accumulation in the baby. On the fifth post partum day OCB and 10-hydroxy-carbazepine (10-OH-CB) levels in plasma in the newborn were only 12 and 7%, respectively, of the values found on the first day after delivery. |
| doi_str_mv | 10.1007/BF00540963 |
| format | Article |
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On the fifth post partum day OCB and 10-hydroxy-carbazepine (10-OH-CB) levels in plasma in the newborn were only 12 and 7%, respectively, of the values found on the first day after delivery.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00540963</identifier><identifier>PMID: 3396622</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Anticonvulsants - blood ; Anticonvulsants - pharmacokinetics ; Anticonvulsants - therapeutic use ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Carbamazepine - analogs & derivatives ; Carbamazepine - blood ; Carbamazepine - pharmacokinetics ; Carbamazepine - therapeutic use ; Female ; Fetal Blood - metabolism ; Half-Life ; Humans ; Infant, Newborn - metabolism ; Medical sciences ; Milk, Human - metabolism ; Neuropharmacology ; Oxcarbazepine ; Pharmacology. 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D</creatorcontrib><creatorcontrib>VON UNRUH, G. E</creatorcontrib><title>Pharmacokinetics of oxcarbazepine and 10-hydroxy-carbazepine in the newborn child of an oxcarbazepine-treated mother</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>Gaschromatography--mass spectrometry (GC/MS) was used to determine plasma levels of oxcarbazepine (OCB) and its main metabolite in a newborn girl and her OCB-treated mother during the first five post partum days. At delivery the maternal and neonatal plasma concentrations were in the same range, indicating considerable placental transfer of both substances. In spite of ingestion of both substances via breast milk, there was no accumulation in the baby. On the fifth post partum day OCB and 10-hydroxy-carbazepine (10-OH-CB) levels in plasma in the newborn were only 12 and 7%, respectively, of the values found on the first day after delivery.</description><subject>Adult</subject><subject>Anticonvulsants - blood</subject><subject>Anticonvulsants - pharmacokinetics</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Carbamazepine - analogs & derivatives</subject><subject>Carbamazepine - blood</subject><subject>Carbamazepine - pharmacokinetics</subject><subject>Carbamazepine - therapeutic use</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Infant, Newborn - metabolism</subject><subject>Medical sciences</subject><subject>Milk, Human - metabolism</subject><subject>Neuropharmacology</subject><subject>Oxcarbazepine</subject><subject>Pharmacology. 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Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Carbamazepine - analogs & derivatives</topic><topic>Carbamazepine - blood</topic><topic>Carbamazepine - pharmacokinetics</topic><topic>Carbamazepine - therapeutic use</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Infant, Newborn - metabolism</topic><topic>Medical sciences</topic><topic>Milk, Human - metabolism</topic><topic>Neuropharmacology</topic><topic>Oxcarbazepine</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BÜLAU, P</creatorcontrib><creatorcontrib>PAAR, W. D</creatorcontrib><creatorcontrib>VON UNRUH, G. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BÜLAU, P</au><au>PAAR, W. D</au><au>VON UNRUH, G. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of oxcarbazepine and 10-hydroxy-carbazepine in the newborn child of an oxcarbazepine-treated mother</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1988-01-01</date><risdate>1988</risdate><volume>34</volume><issue>3</issue><spage>311</spage><epage>313</epage><pages>311-313</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Gaschromatography--mass spectrometry (GC/MS) was used to determine plasma levels of oxcarbazepine (OCB) and its main metabolite in a newborn girl and her OCB-treated mother during the first five post partum days. At delivery the maternal and neonatal plasma concentrations were in the same range, indicating considerable placental transfer of both substances. In spite of ingestion of both substances via breast milk, there was no accumulation in the baby. On the fifth post partum day OCB and 10-hydroxy-carbazepine (10-OH-CB) levels in plasma in the newborn were only 12 and 7%, respectively, of the values found on the first day after delivery.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>3396622</pmid><doi>10.1007/BF00540963</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1988-01, Vol.34 (3), p.311-313 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Anticonvulsants - blood Anticonvulsants - pharmacokinetics Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Carbamazepine - analogs & derivatives Carbamazepine - blood Carbamazepine - pharmacokinetics Carbamazepine - therapeutic use Female Fetal Blood - metabolism Half-Life Humans Infant, Newborn - metabolism Medical sciences Milk, Human - metabolism Neuropharmacology Oxcarbazepine Pharmacology. Drug treatments |
| title | Pharmacokinetics of oxcarbazepine and 10-hydroxy-carbazepine in the newborn child of an oxcarbazepine-treated mother |
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