A T cell epitope for experimental allergic neuritis
A synthetic peptide representing residues 57–81 of the bovine P 2 protein produced severe paralytic experimental allergic neuritis (EAN) in Lewis rats. Peptide 57–81 could also be used to stimulate a P 2 protein-specific T cell line to transfer paralytic EAN to naive recipient rats. A smaller peptid...
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| Veröffentlicht in: | Journal of neuroimmunology 1988-08, Vol.19 (1), p.167-173 |
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| container_end_page | 173 |
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| container_title | Journal of neuroimmunology |
| container_volume | 19 |
| creator | Olee, Tsaiwei Powers, James M. Brostoff, Steven W. |
| description | A synthetic peptide representing residues 57–81 of the bovine P
2 protein produced severe paralytic experimental allergic neuritis (EAN) in Lewis rats. Peptide 57–81 could also be used to stimulate a P
2 protein-specific T cell line to transfer paralytic EAN to naive recipient rats. A smaller peptide representing residues 60–81 produced a milder form of clinical disease. Residues 60–81 are the shortest peptide sequence thus far described which can produce clinical EAN. The structural predictions for the sequence represented by these peptides support the contention that T cell antigenic sites tend to be amphipathic α-helical structures. |
| doi_str_mv | 10.1016/0165-5728(88)90046-X |
| format | Article |
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2 protein produced severe paralytic experimental allergic neuritis (EAN) in Lewis rats. Peptide 57–81 could also be used to stimulate a P
2 protein-specific T cell line to transfer paralytic EAN to naive recipient rats. A smaller peptide representing residues 60–81 produced a milder form of clinical disease. Residues 60–81 are the shortest peptide sequence thus far described which can produce clinical EAN. The structural predictions for the sequence represented by these peptides support the contention that T cell antigenic sites tend to be amphipathic α-helical structures.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/0165-5728(88)90046-X</identifier><identifier>PMID: 2456303</identifier><identifier>CODEN: JNRIDW</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Autoimmunity (experimental aspects and models) ; Biological and medical sciences ; Epitopes ; Experimental allergic neuritis ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Lewis rat ; Lymphocyte Activation ; Myelin Basic Protein - immunology ; Myelin P2 Protein ; Neuritis, Autoimmune, Experimental - immunology ; Peptides - chemical synthesis ; Peptides - immunology ; Protein Conformation ; Rats ; T cell epitope ; T-Lymphocytes - immunology</subject><ispartof>Journal of neuroimmunology, 1988-08, Vol.19 (1), p.167-173</ispartof><rights>1988</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e07d82cc4ecca38d19cfab9cdf1bb207725048ba0643898f85afa761970bfe583</citedby><cites>FETCH-LOGICAL-c417t-e07d82cc4ecca38d19cfab9cdf1bb207725048ba0643898f85afa761970bfe583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016557288890046X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7838313$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2456303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olee, Tsaiwei</creatorcontrib><creatorcontrib>Powers, James M.</creatorcontrib><creatorcontrib>Brostoff, Steven W.</creatorcontrib><title>A T cell epitope for experimental allergic neuritis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>A synthetic peptide representing residues 57–81 of the bovine P
2 protein produced severe paralytic experimental allergic neuritis (EAN) in Lewis rats. Peptide 57–81 could also be used to stimulate a P
2 protein-specific T cell line to transfer paralytic EAN to naive recipient rats. A smaller peptide representing residues 60–81 produced a milder form of clinical disease. Residues 60–81 are the shortest peptide sequence thus far described which can produce clinical EAN. The structural predictions for the sequence represented by these peptides support the contention that T cell antigenic sites tend to be amphipathic α-helical structures.</description><subject>Animals</subject><subject>Autoimmunity (experimental aspects and models)</subject><subject>Biological and medical sciences</subject><subject>Epitopes</subject><subject>Experimental allergic neuritis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Lewis rat</subject><subject>Lymphocyte Activation</subject><subject>Myelin Basic Protein - immunology</subject><subject>Myelin P2 Protein</subject><subject>Neuritis, Autoimmune, Experimental - immunology</subject><subject>Peptides - chemical synthesis</subject><subject>Peptides - immunology</subject><subject>Protein Conformation</subject><subject>Rats</subject><subject>T cell epitope</subject><subject>T-Lymphocytes - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo6_rxDxR6ENFDNWnSZnoRlsUvWPCywt5Cmk4k0m1r0or-e1t32aMehjnMM8M7DyFnjN4wyrLbodI4lQlcAVznlIosXu2RKQOZxCAStk-mO-SQHIXwTilLucgnZJKINOOUTwmfRcvIYFVF2LquaTGyjY_wq0Xv1lh3uop0VaF_cyaqsfeuc-GEHFhdBTzd9mPy-nC_nD_Fi5fH5_lsERvBZBcjlSUkxgg0RnMoWW6sLnJTWlYUCZUySamAQtNMcMjBQqqtlhnLJS0spsCPyeXmbuubjx5Dp9YujFl1jU0flAQuEi7-B1nKBGScD6DYgMY3IXi0qh3e1P5bMapGqWo0pkZjCkD9SlWrYe18e78v1ljulrYWh_nFdq6D0ZX1ujYu7LAhJ3A2YncbDAdpnw69CsZhbbB0Hk2nysb9neMHPEuR_w</recordid><startdate>19880801</startdate><enddate>19880801</enddate><creator>Olee, Tsaiwei</creator><creator>Powers, James M.</creator><creator>Brostoff, Steven W.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19880801</creationdate><title>A T cell epitope for experimental allergic neuritis</title><author>Olee, Tsaiwei ; Powers, James M. ; Brostoff, Steven W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-e07d82cc4ecca38d19cfab9cdf1bb207725048ba0643898f85afa761970bfe583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Autoimmunity (experimental aspects and models)</topic><topic>Biological and medical sciences</topic><topic>Epitopes</topic><topic>Experimental allergic neuritis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Lewis rat</topic><topic>Lymphocyte Activation</topic><topic>Myelin Basic Protein - immunology</topic><topic>Myelin P2 Protein</topic><topic>Neuritis, Autoimmune, Experimental - immunology</topic><topic>Peptides - chemical synthesis</topic><topic>Peptides - immunology</topic><topic>Protein Conformation</topic><topic>Rats</topic><topic>T cell epitope</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olee, Tsaiwei</creatorcontrib><creatorcontrib>Powers, James M.</creatorcontrib><creatorcontrib>Brostoff, Steven W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olee, Tsaiwei</au><au>Powers, James M.</au><au>Brostoff, Steven W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A T cell epitope for experimental allergic neuritis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1988-08-01</date><risdate>1988</risdate><volume>19</volume><issue>1</issue><spage>167</spage><epage>173</epage><pages>167-173</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><coden>JNRIDW</coden><abstract>A synthetic peptide representing residues 57–81 of the bovine P
2 protein produced severe paralytic experimental allergic neuritis (EAN) in Lewis rats. Peptide 57–81 could also be used to stimulate a P
2 protein-specific T cell line to transfer paralytic EAN to naive recipient rats. A smaller peptide representing residues 60–81 produced a milder form of clinical disease. Residues 60–81 are the shortest peptide sequence thus far described which can produce clinical EAN. The structural predictions for the sequence represented by these peptides support the contention that T cell antigenic sites tend to be amphipathic α-helical structures.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2456303</pmid><doi>10.1016/0165-5728(88)90046-X</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 1988-08, Vol.19 (1), p.167-173 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Autoimmunity (experimental aspects and models) Biological and medical sciences Epitopes Experimental allergic neuritis Fundamental and applied biological sciences. Psychology Fundamental immunology Lewis rat Lymphocyte Activation Myelin Basic Protein - immunology Myelin P2 Protein Neuritis, Autoimmune, Experimental - immunology Peptides - chemical synthesis Peptides - immunology Protein Conformation Rats T cell epitope T-Lymphocytes - immunology |
| title | A T cell epitope for experimental allergic neuritis |
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