Role of recombinational repair in sensitivity to an antitumour agent that inhibits bacteriophage T4 type II DNA topoisomerase

Summary The bacteriophage T4‐encoded type II DNA topoisomerase is the major target for the antitumour agent m‐AMSA (4‐(9‐acridinylamino)methanesulphon‐m‐anisidide) in phage‐infected bacterial cells. Inhibition of the purified enzyme by m‐AMSA results in formation of a cleavage complex that contains...

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Veröffentlicht in:	Molecular microbiology 1996-06, Vol.20 (6), p.1145-1154
Hauptverfasser:	Neece, Sue H., Carles‐Kinch, Kelly, Tomso, Daniel J., Kreuzer, Kenneth N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amsacrine - pharmacology Antineoplastic Agents - pharmacology Bacteriophage T4 - drug effects Bacteriophage T4 - enzymology DNA Repair DNA Topoisomerases, Type II - genetics DNA, Viral Gene Deletion phage T4 Recombination, Genetic Topoisomerase II Inhibitors
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