2-(2-Aryl-2-oxoethylidene)-1,2,3,4-tetrahydropyridines. Novel isomers of 1,4-dihydropyridine calcium channel blockers

The title compounds are novel double bond isomers of 1,4-dihydropyridine-type calcium channel blockers (CCB). These derivatives were prepared by using the Hantzsch dihydropyridine synthesis. The assignment of structure was based on spectroscopic data and a regiochemically unambiguous synthesis. Seve...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1988-08, Vol.31 (8), p.1659-1664
Hauptverfasser:	Taylor, Michael D, Badger, Edward W, Steffen, Robert P, Haleen, Stephen J, Pugsley, Thomas A, Shih, Yu Hsin, Weishaar, Ronald E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects calcium Calcium Channel Blockers - chemical synthesis Calcium Channels Chemistry Coronary Vessels - drug effects Exact sciences and technology heart Heart - drug effects Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives In Vitro Techniques Isomerism Nifedipine - pharmacology Nitrendipine - metabolism Organic chemistry Preparations and properties Pyridines - chemical synthesis Pyridines - pharmacology Rabbits Rats Receptors, Nicotinic - drug effects Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!