Ornithine decarboxylase antizyme: a novel type of regulatory protein
Antizyme plays an important regulatory role in the synthesis of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating polyamine uptake, antizyme is induced by polyamine-enhanced translational frameshifting, and binds to ODC, accelerating its AT...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) 1996, Vol.21 (1), p.27-30 |
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| container_title | Trends in biochemical sciences (Amsterdam. Regular ed.) |
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| creator | Hayashi, Shin-ichi Murakami, Yasuko Matsufuji, Senya |
| description | Antizyme plays an important regulatory role in the synthesis of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating polyamine uptake, antizyme is induced by polyamine-enhanced translational frameshifting, and binds to ODC, accelerating its ATP-dependent degradation, a process catalysed by the 26S proteasome. |
| doi_str_mv | 10.1016/S0968-0004(06)80024-1 |
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| ispartof | Trends in biochemical sciences (Amsterdam. Regular ed.), 1996, Vol.21 (1), p.27-30 |
| issn | 0968-0004 1362-4326 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Enzyme Inhibitors - metabolism Humans Ornithine Decarboxylase Inhibitors Peptide Hydrolases - metabolism Proteasome Endopeptidase Complex Proteins - metabolism |
| title | Ornithine decarboxylase antizyme: a novel type of regulatory protein |
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