Ornithine decarboxylase antizyme: a novel type of regulatory protein

Antizyme plays an important regulatory role in the synthesis of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating polyamine uptake, antizyme is induced by polyamine-enhanced translational frameshifting, and binds to ODC, accelerating its AT...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 1996, Vol.21 (1), p.27-30
Hauptverfasser:	Hayashi, Shin-ichi, Murakami, Yasuko, Matsufuji, Senya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Enzyme Inhibitors - metabolism Humans Ornithine Decarboxylase Inhibitors Peptide Hydrolases - metabolism Proteasome Endopeptidase Complex Proteins - metabolism
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Beschreibung
Zusammenfassung:	Antizyme plays an important regulatory role in the synthesis of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating polyamine uptake, antizyme is induced by polyamine-enhanced translational frameshifting, and binds to ODC, accelerating its ATP-dependent degradation, a process catalysed by the 26S proteasome.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/S0968-0004(06)80024-1