NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels

NO causes pulmonary vasodilation in patients with pulmonary hypertension. In pulmonary arterial smooth muscle cells, the activity of voltage-gated K+ (Kv) channels controls resting membrane potential. In turn, membrane potential is an important regulator of the intracellular free calcium concentrati...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-09, Vol.93 (19), p.10489-10494
Hauptverfasser:	Yuan, X J, Tod, M L, Rubin, L J, Blaustein, M P
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Action Potentials Animals Calcium - metabolism Cell Membrane - physiology Cells, Cultured Ion Channel Gating Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Nitric Oxide - pharmacology Nitroprusside - pharmacology Patch-Clamp Techniques Potassium Channels - drug effects Potassium Channels - physiology Pulmonary Artery - physiology Rats Sodium Nitrite - pharmacology Vasodilation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!