Hypothalamic-pituitary-adrenal axis activity in panic disorder: Effects of alprazolam on 24 h secretion of adrenocorticotropin and cortisol

Pre-clinical and some clinical evidence suggests that central overdrive within the hypothalamic-pituitary-adrenal (HPA) axis may play a role in panic disorder, and that the anti-panic efficacy of alprazolam may involve its ability to inhibit this drive. Detailed examination of 24 h secretion of adre...

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Veröffentlicht in:	Journal of psychiatric research 1996-03, Vol.30 (2), p.79-93
Hauptverfasser:	Abelson, James L., Curtis, George C., Cameron, Oliver G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Adult Alprazolam - therapeutic use Anti-Anxiety Agents - therapeutic use Arousal - drug effects Arousal - physiology Biological and medical sciences Circadian Rhythm - drug effects Circadian Rhythm - physiology Corticotropin-Releasing Hormone - physiology Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Hydrocortisone - blood Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiopathology Male Medical sciences Neuropharmacology Panic Disorder - drug therapy Panic Disorder - physiopathology Pharmacology. Drug treatments Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiopathology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Treatment Outcome
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