Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast
Metastatic ovarian carcinoma to the breast is rare. It represents a diagnostic challenge to the cytologist. It usually signifies a progressive widespread metastatic ovarian tumor with a poor prognosis. This report evaluates the breast fine‐needle aspiration (FNA) cytomorphologic features of six case...
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| Veröffentlicht in: | Diagnostic cytopathology 1996-07, Vol.15 (1), p.1-6 |
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| creator | Raptis, Stavros Kanbour, Anisa I. Dusenbery, David Kanbour-Shakir, Amal |
| description | Metastatic ovarian carcinoma to the breast is rare. It represents a diagnostic challenge to the cytologist. It usually signifies a progressive widespread metastatic ovarian tumor with a poor prognosis. This report evaluates the breast fine‐needle aspiration (FNA) cytomorphologic features of six cases of metastatic ovarian carcinoma and compares them to those reported in the literature.
The cytologic features included hypercellularity, abundant papillary fragments, and necrotic background. The tumor cells showed high nuclear/cytoplasmic ratio, anisonucleosis, prominent nucleoli, and psammoma bodies in cases of serous papillary carcinoma. In addition, the clear‐cell carcinoma had prominent finely vacuolated and clear cytoplasm, multinucleated giant cells, and papillary fragments with hobnail nuclei.
Recognition of these unusual patterns in a breast FNA cytology should raise the suspicion of a metastatic ovarian tumor. Direct comparison between the breast FNA cytology and the original primary ovarian tumor should confirm the diagnosis. The proper diagnosis of metastatic ovarian cancer to the breast will prevent unnecessary surgical treatment and ensure the appropriate therapy. Diagn Cytopathol 1996;15:1–6. © 1996 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0339(199607)15:1<1::AID-DC2>3.0.CO;2-N |
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The cytologic features included hypercellularity, abundant papillary fragments, and necrotic background. The tumor cells showed high nuclear/cytoplasmic ratio, anisonucleosis, prominent nucleoli, and psammoma bodies in cases of serous papillary carcinoma. In addition, the clear‐cell carcinoma had prominent finely vacuolated and clear cytoplasm, multinucleated giant cells, and papillary fragments with hobnail nuclei.
Recognition of these unusual patterns in a breast FNA cytology should raise the suspicion of a metastatic ovarian tumor. Direct comparison between the breast FNA cytology and the original primary ovarian tumor should confirm the diagnosis. The proper diagnosis of metastatic ovarian cancer to the breast will prevent unnecessary surgical treatment and ensure the appropriate therapy. Diagn Cytopathol 1996;15:1–6. © 1996 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-1039</identifier><identifier>EISSN: 1097-0339</identifier><identifier>DOI: 10.1002/(SICI)1097-0339(199607)15:1<1::AID-DC2>3.0.CO;2-N</identifier><identifier>PMID: 8807244</identifier><identifier>CODEN: DICYE7</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma, Clear Cell - pathology ; Adenocarcinoma, Clear Cell - secondary ; Adult ; Aged ; Biological and medical sciences ; Biopsy, Needle - methods ; Breast Neoplasms - pathology ; Breast Neoplasms - secondary ; CA-125 Antigen - blood ; carcinoma to the breast ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - secondary ; Cell Nucleus - pathology ; Cystadenocarcinoma, Papillary - pathology ; Cystadenocarcinoma, Papillary - secondary ; Cytoplasm - pathology ; Female ; Female genital diseases ; fine-needle aspiration ; Genital system. Mammary gland ; Gynecology. Andrology. Obstetrics ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; metastatic ovarian carcinoma ; Middle Aged ; Neoplasm Staging ; Ovarian Neoplasms - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Tumors</subject><ispartof>Diagnostic cytopathology, 1996-07, Vol.15 (1), p.1-6</ispartof><rights>Copyright © 1996 Wiley‐Liss, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4202-4beb10d7ea1efa280855f70032abbf8ffb1acc373afc5619e596cab26288ae6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0339%28199607%2915%3A1%3C1%3A%3AAID-DC2%3E3.0.CO%3B2-N$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0339%28199607%2915%3A1%3C1%3A%3AAID-DC2%3E3.0.CO%3B2-N$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3142840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8807244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raptis, Stavros</creatorcontrib><creatorcontrib>Kanbour, Anisa I.</creatorcontrib><creatorcontrib>Dusenbery, David</creatorcontrib><creatorcontrib>Kanbour-Shakir, Amal</creatorcontrib><title>Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast</title><title>Diagnostic cytopathology</title><addtitle>Diagn. Cytopathol</addtitle><description>Metastatic ovarian carcinoma to the breast is rare. It represents a diagnostic challenge to the cytologist. It usually signifies a progressive widespread metastatic ovarian tumor with a poor prognosis. This report evaluates the breast fine‐needle aspiration (FNA) cytomorphologic features of six cases of metastatic ovarian carcinoma and compares them to those reported in the literature.
The cytologic features included hypercellularity, abundant papillary fragments, and necrotic background. The tumor cells showed high nuclear/cytoplasmic ratio, anisonucleosis, prominent nucleoli, and psammoma bodies in cases of serous papillary carcinoma. In addition, the clear‐cell carcinoma had prominent finely vacuolated and clear cytoplasm, multinucleated giant cells, and papillary fragments with hobnail nuclei.
Recognition of these unusual patterns in a breast FNA cytology should raise the suspicion of a metastatic ovarian tumor. Direct comparison between the breast FNA cytology and the original primary ovarian tumor should confirm the diagnosis. The proper diagnosis of metastatic ovarian cancer to the breast will prevent unnecessary surgical treatment and ensure the appropriate therapy. Diagn Cytopathol 1996;15:1–6. © 1996 Wiley‐Liss, Inc.</description><subject>Adenocarcinoma, Clear Cell - pathology</subject><subject>Adenocarcinoma, Clear Cell - secondary</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle - methods</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - secondary</subject><subject>CA-125 Antigen - blood</subject><subject>carcinoma to the breast</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Ductal, Breast - secondary</subject><subject>Cell Nucleus - pathology</subject><subject>Cystadenocarcinoma, Papillary - pathology</subject><subject>Cystadenocarcinoma, Papillary - secondary</subject><subject>Cytoplasm - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>fine-needle aspiration</subject><subject>Genital system. Mammary gland</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>metastatic ovarian carcinoma</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Tumors</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1v0zAUhi0EGt3gJyDlAqHtIsUfSZwUhDSldFQr7RAgLo9OXBsCSVzsdNB_j6NUvZmEfGHZ59F7Xj2EFIxOGaX89eXnZbm8YrSQMRWiuGRFkVF5xdIZe8tms-vlPJ6X_J2Y0mm5ecPj9SMyOdGPySSXaRozKoqn5Nz7n5TSgrPsjJzlOZU8SSbk46LudNxpvW10hH5XO-xr20Xq0NvGfj9E1kSt7tH34V9F9h5djWGMTtWdbTHqbdT_0FHldGCekScGG6-fH-8L8nXx_kv5IV5tbpbl9SpWCac8TipdMbqVGpk2yHOap6mRlAqOVWVyYyqGSgkp0Kg0Y4VOi0xhxTOe56izrbggr8bcnbO_99r30NZe6abBTtu9B5kLwYRMAvhpBJWz3jttYOfqFt0BGIVBMcCgGAZpMEiDUTGwFFg4EBRDUAwCKJQb4LAOmS-Oy_dVq7enxKPTMH95nKNX2BiHnar9CRMs4XlCA3Y3Yn_qRh8e9PpvrYethmeIjMfI2vf67ykS3S_IpJApfFvfQLm6vZ3PFwzuxD9GdLEx</recordid><startdate>199607</startdate><enddate>199607</enddate><creator>Raptis, Stavros</creator><creator>Kanbour, Anisa I.</creator><creator>Dusenbery, David</creator><creator>Kanbour-Shakir, Amal</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199607</creationdate><title>Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast</title><author>Raptis, Stavros ; Kanbour, Anisa I. ; Dusenbery, David ; Kanbour-Shakir, Amal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4202-4beb10d7ea1efa280855f70032abbf8ffb1acc373afc5619e596cab26288ae6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenocarcinoma, Clear Cell - pathology</topic><topic>Adenocarcinoma, Clear Cell - secondary</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle - methods</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - secondary</topic><topic>CA-125 Antigen - blood</topic><topic>carcinoma to the breast</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Ductal, Breast - secondary</topic><topic>Cell Nucleus - pathology</topic><topic>Cystadenocarcinoma, Papillary - pathology</topic><topic>Cystadenocarcinoma, Papillary - secondary</topic><topic>Cytoplasm - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>fine-needle aspiration</topic><topic>Genital system. Mammary gland</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>metastatic ovarian carcinoma</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raptis, Stavros</creatorcontrib><creatorcontrib>Kanbour, Anisa I.</creatorcontrib><creatorcontrib>Dusenbery, David</creatorcontrib><creatorcontrib>Kanbour-Shakir, Amal</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raptis, Stavros</au><au>Kanbour, Anisa I.</au><au>Dusenbery, David</au><au>Kanbour-Shakir, Amal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn. Cytopathol</addtitle><date>1996-07</date><risdate>1996</risdate><volume>15</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><coden>DICYE7</coden><abstract>Metastatic ovarian carcinoma to the breast is rare. It represents a diagnostic challenge to the cytologist. It usually signifies a progressive widespread metastatic ovarian tumor with a poor prognosis. This report evaluates the breast fine‐needle aspiration (FNA) cytomorphologic features of six cases of metastatic ovarian carcinoma and compares them to those reported in the literature.
The cytologic features included hypercellularity, abundant papillary fragments, and necrotic background. The tumor cells showed high nuclear/cytoplasmic ratio, anisonucleosis, prominent nucleoli, and psammoma bodies in cases of serous papillary carcinoma. In addition, the clear‐cell carcinoma had prominent finely vacuolated and clear cytoplasm, multinucleated giant cells, and papillary fragments with hobnail nuclei.
Recognition of these unusual patterns in a breast FNA cytology should raise the suspicion of a metastatic ovarian tumor. Direct comparison between the breast FNA cytology and the original primary ovarian tumor should confirm the diagnosis. The proper diagnosis of metastatic ovarian cancer to the breast will prevent unnecessary surgical treatment and ensure the appropriate therapy. Diagn Cytopathol 1996;15:1–6. © 1996 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8807244</pmid><doi>10.1002/(SICI)1097-0339(199607)15:1<1::AID-DC2>3.0.CO;2-N</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma, Clear Cell - pathology Adenocarcinoma, Clear Cell - secondary Adult Aged Biological and medical sciences Biopsy, Needle - methods Breast Neoplasms - pathology Breast Neoplasms - secondary CA-125 Antigen - blood carcinoma to the breast Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - secondary Cell Nucleus - pathology Cystadenocarcinoma, Papillary - pathology Cystadenocarcinoma, Papillary - secondary Cytoplasm - pathology Female Female genital diseases fine-needle aspiration Genital system. Mammary gland Gynecology. Andrology. Obstetrics Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences metastatic ovarian carcinoma Middle Aged Neoplasm Staging Ovarian Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Tumors |
| title | Fine-needle aspiration cytology of metastatic ovarian carcinoma to the breast |
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