Adriamycin-dependent peroxidation of rat liver and heart microsomes catalysed by iron chelates and ferritin: Maximum peroxidation at low oxygen partial pressures
NADPH- and iron-dependent lipid peroxidation of rat heart and liver microsomes was measured in the presence and absence of adriamycin. Lipid peroxidation was enhanced by adriamycin when incubated in air and was increased as the pO 2 was lowered, to a maximum of 3–4 times the aerobic level at a pO 2...
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| Veröffentlicht in: | Biochemical pharmacology 1988-08, Vol.37 (15), p.2893-2897 |
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| container_title | Biochemical pharmacology |
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| creator | Vile, Glenn F. Winterbourn, Christine C. |
| description | NADPH- and iron-dependent lipid peroxidation of rat heart and liver microsomes was measured in the presence and absence of adriamycin. Lipid peroxidation was enhanced by adriamycin when incubated in air and was increased as the pO
2 was lowered, to a maximum of 3–4 times the aerobic level at a pO
2 of approx. 4 mm Hg. Fe-ADP, Fe-ATP and ferritin were able to catalyse adriamycin-dependent peroxidation of microsomes under low p0
2. Superoxide dismutase and catalase had minimal effect. These results indicate that adriamycin-dependent lipid peroxidation is favoured by the low O
2 concentrations that exist in active muscle cells and suggest that ferritin could provide the iron catalyst for the reaction. |
| doi_str_mv | 10.1016/0006-2952(88)90273-0 |
| format | Article |
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2 was lowered, to a maximum of 3–4 times the aerobic level at a pO
2 of approx. 4 mm Hg. Fe-ADP, Fe-ATP and ferritin were able to catalyse adriamycin-dependent peroxidation of microsomes under low p0
2. Superoxide dismutase and catalase had minimal effect. These results indicate that adriamycin-dependent lipid peroxidation is favoured by the low O
2 concentrations that exist in active muscle cells and suggest that ferritin could provide the iron catalyst for the reaction.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(88)90273-0</identifier><identifier>PMID: 3395366</identifier><identifier>CODEN: BCPCA6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Doxorubicin - pharmacology ; Drug toxicity and drugs side effects treatment ; Ferritins - pharmacology ; Iron Chelating Agents - pharmacology ; Lipid Peroxides - metabolism ; Medical sciences ; Microsomes - drug effects ; Microsomes - metabolism ; Microsomes, Liver - metabolism ; Myocardium - metabolism ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Toxicity: cardiovascular system</subject><ispartof>Biochemical pharmacology, 1988-08, Vol.37 (15), p.2893-2897</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006295288902730$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7261822$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3395366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vile, Glenn F.</creatorcontrib><creatorcontrib>Winterbourn, Christine C.</creatorcontrib><title>Adriamycin-dependent peroxidation of rat liver and heart microsomes catalysed by iron chelates and ferritin: Maximum peroxidation at low oxygen partial pressures</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>NADPH- and iron-dependent lipid peroxidation of rat heart and liver microsomes was measured in the presence and absence of adriamycin. Lipid peroxidation was enhanced by adriamycin when incubated in air and was increased as the pO
2 was lowered, to a maximum of 3–4 times the aerobic level at a pO
2 of approx. 4 mm Hg. Fe-ADP, Fe-ATP and ferritin were able to catalyse adriamycin-dependent peroxidation of microsomes under low p0
2. Superoxide dismutase and catalase had minimal effect. These results indicate that adriamycin-dependent lipid peroxidation is favoured by the low O
2 concentrations that exist in active muscle cells and suggest that ferritin could provide the iron catalyst for the reaction.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Ferritins - pharmacology</subject><subject>Iron Chelating Agents - pharmacology</subject><subject>Lipid Peroxides - metabolism</subject><subject>Medical sciences</subject><subject>Microsomes - drug effects</subject><subject>Microsomes - metabolism</subject><subject>Microsomes, Liver - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Toxicity: cardiovascular system</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc2OFCEUhYnRjG3rG2jCwhhdlPIzUJQLk8nEv2SMG10TGi4OpgpKoMaux_FNpZzOJG4ul5yPk3AOQk8peU0JlW8IIbJjg2AvlXo1ENbzjtxDO6rawgap7qPdHfIQPSrl53ZVkp6hM84HwaXcoT8XLgczrTbEzsEM0UGseIacjsGZGlLEyeNsKh7DDWRsosPXYHLFU7A5lTRBwdZUM64FHD6sOOT2xl7DaGqTNt5DzqGG-BZ_MccwLdP__pt3-o3Tcf0BEc_NO5gRzxlKWdp4jB54MxZ4cjr36PuH998uP3VXXz9-vry46oBTXjvBXU-kYR68EmJwHgiXjvNzwYbzA7HCMkKE430P3kkiqFDKsL63B987qiTfoxe3vnNOvxYoVU-hWBhHEyEtRfeKc8Jbynv07AQuhwmcnnOYTF71KdOmPz_pplgz-myiDeUO65mkirGGvbvFoH3qJkDWxQaIFlzIYKt2KWhK9Fa13orTW49aKf2vak34XwgXncc</recordid><startdate>19880801</startdate><enddate>19880801</enddate><creator>Vile, Glenn F.</creator><creator>Winterbourn, Christine C.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19880801</creationdate><title>Adriamycin-dependent peroxidation of rat liver and heart microsomes catalysed by iron chelates and ferritin: Maximum peroxidation at low oxygen partial pressures</title><author>Vile, Glenn F. ; Winterbourn, Christine C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e313t-53d706a2fef8559dfe036d3345294b0c5c2005d377efd6051588a277cbf7d1863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Ferritins - pharmacology</topic><topic>Iron Chelating Agents - pharmacology</topic><topic>Lipid Peroxides - metabolism</topic><topic>Medical sciences</topic><topic>Microsomes - drug effects</topic><topic>Microsomes - metabolism</topic><topic>Microsomes, Liver - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Toxicity: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vile, Glenn F.</creatorcontrib><creatorcontrib>Winterbourn, Christine C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vile, Glenn F.</au><au>Winterbourn, Christine C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adriamycin-dependent peroxidation of rat liver and heart microsomes catalysed by iron chelates and ferritin: Maximum peroxidation at low oxygen partial pressures</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1988-08-01</date><risdate>1988</risdate><volume>37</volume><issue>15</issue><spage>2893</spage><epage>2897</epage><pages>2893-2897</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>NADPH- and iron-dependent lipid peroxidation of rat heart and liver microsomes was measured in the presence and absence of adriamycin. Lipid peroxidation was enhanced by adriamycin when incubated in air and was increased as the pO
2 was lowered, to a maximum of 3–4 times the aerobic level at a pO
2 of approx. 4 mm Hg. Fe-ADP, Fe-ATP and ferritin were able to catalyse adriamycin-dependent peroxidation of microsomes under low p0
2. Superoxide dismutase and catalase had minimal effect. These results indicate that adriamycin-dependent lipid peroxidation is favoured by the low O
2 concentrations that exist in active muscle cells and suggest that ferritin could provide the iron catalyst for the reaction.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3395366</pmid><doi>10.1016/0006-2952(88)90273-0</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical pharmacology, 1988-08, Vol.37 (15), p.2893-2897 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Doxorubicin - pharmacology Drug toxicity and drugs side effects treatment Ferritins - pharmacology Iron Chelating Agents - pharmacology Lipid Peroxides - metabolism Medical sciences Microsomes - drug effects Microsomes - metabolism Microsomes, Liver - metabolism Myocardium - metabolism Pharmacology. Drug treatments Rats Rats, Inbred Strains Toxicity: cardiovascular system |
| title | Adriamycin-dependent peroxidation of rat liver and heart microsomes catalysed by iron chelates and ferritin: Maximum peroxidation at low oxygen partial pressures |
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