DOWN-REGULATION OF ANGIOTENSIN II RECEPTORS IN HYPERTROPHIED HUMAN MYOCARDIUM

SUMMARY 1. Specific [125I]‐angiotensin II (AngII) binding in normal and hypertrophied human myocardial membranes was saturable and of high affinity. Low concentrations of unlabelled AngII and saralasin competed with [125I]‐AngII for the binding sites in these tissues. Thus, saturable [125I]‐AngII bi...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1996-07, Vol.23 (6-7), p.514-518
Hauptverfasser:	Nozawa, Yoshihisa, Miyake, Hidekazu, Haruno, Akihiro, Yamada, Shizuo, Uchida, Shinya, Ohkura, Takashi, Kimura, Ryohei, Suzuki, Harumi, Hoshino, Tsuneo
Format:	Artikel
Sprache:	eng
Schlagworte:	[125I]-angiotensin II Aged Angiotensin II - metabolism angiotensin II receptors Angiotensin Receptor Antagonists cardiac hypertrophy Cardiomegaly - metabolism Down-Regulation - physiology Female human myocardium Humans Imidazoles - pharmacology In Vitro Techniques Iodine Radioisotopes Iodocyanopindolol Kinetics Male Membranes - metabolism Middle Aged Myocardium - metabolism Pindolol - analogs & derivatives Pyridines - pharmacology receptor subtype Receptors, Angiotensin - biosynthesis
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