Chemotransduction in the carotid body : K+ current modulated by PO2 in type I chemoreceptor cells
The ionic currents of carotid body type I cells and their possible involvement in the detection of oxygen tension (Po2) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can be al...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1988-07, Vol.241 (4865), p.580-582 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | LOPEZ-BARNEO, J LOPEZ-LOPEZ, J. R URENA, J GONZALEZ, C |
| description | The ionic currents of carotid body type I cells and their possible involvement in the detection of oxygen tension (Po2) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can be altered by changes in PO2 was tested. The results show that type I cells have voltage-dependent sodium, calcium, and potassium channels. Sodium and calcium currents were unaffected by a decrease in PO2 from 150 to 10 millimeters of mercury, whereas, with the same experimental protocol, potassium currents were reversibly reduced by 25 to 50 percent. The effect of hypoxia was independent of internal adenosine triphosphate and calcium. Thus, ionic conductances, and particularly the O2-sensitive potassium current, play a key role in the transduction mechanism of arterial chemoreceptors. |
| doi_str_mv | 10.1126/science.2456613 |
| format | Article |
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R ; URENA, J ; GONZALEZ, C</creator><creatorcontrib>LOPEZ-BARNEO, J ; LOPEZ-LOPEZ, J. R ; URENA, J ; GONZALEZ, C</creatorcontrib><description>The ionic currents of carotid body type I cells and their possible involvement in the detection of oxygen tension (Po2) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can be altered by changes in PO2 was tested. The results show that type I cells have voltage-dependent sodium, calcium, and potassium channels. Sodium and calcium currents were unaffected by a decrease in PO2 from 150 to 10 millimeters of mercury, whereas, with the same experimental protocol, potassium currents were reversibly reduced by 25 to 50 percent. The effect of hypoxia was independent of internal adenosine triphosphate and calcium. Thus, ionic conductances, and particularly the O2-sensitive potassium current, play a key role in the transduction mechanism of arterial chemoreceptors.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2456613</identifier><identifier>PMID: 2456613</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animals ; Biological and medical sciences ; Blood ; Calcium - physiology ; Carotid Body - physiology ; Cells, Cultured ; Chemoreceptor Cells - physiology ; Electric Conductivity ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Ion Channels - physiology ; Medical research ; Membrane Potentials ; Minerals ; Oxygen ; Oxygen - blood ; Potassium - physiology ; Rabbits ; Sodium - physiology ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 1988-07, Vol.241 (4865), p.580-582</ispartof><rights>1989 INIST-CNRS</rights><rights>Copyright American Association for the Advancement of Science Jul 29, 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7053927$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2456613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOPEZ-BARNEO, J</creatorcontrib><creatorcontrib>LOPEZ-LOPEZ, J. R</creatorcontrib><creatorcontrib>URENA, J</creatorcontrib><creatorcontrib>GONZALEZ, C</creatorcontrib><title>Chemotransduction in the carotid body : K+ current modulated by PO2 in type I chemoreceptor cells</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The ionic currents of carotid body type I cells and their possible involvement in the detection of oxygen tension (Po2) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can be altered by changes in PO2 was tested. The results show that type I cells have voltage-dependent sodium, calcium, and potassium channels. Sodium and calcium currents were unaffected by a decrease in PO2 from 150 to 10 millimeters of mercury, whereas, with the same experimental protocol, potassium currents were reversibly reduced by 25 to 50 percent. The effect of hypoxia was independent of internal adenosine triphosphate and calcium. Thus, ionic conductances, and particularly the O2-sensitive potassium current, play a key role in the transduction mechanism of arterial chemoreceptors.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Calcium - physiology</subject><subject>Carotid Body - physiology</subject><subject>Cells, Cultured</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Electric Conductivity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Ion Channels - physiology</subject><subject>Medical research</subject><subject>Membrane Potentials</subject><subject>Minerals</subject><subject>Oxygen</subject><subject>Oxygen - blood</subject><subject>Potassium - physiology</subject><subject>Rabbits</subject><subject>Sodium - physiology</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0T1PwzAQBmALgUr5mJmQLIRYUMD2xbHNhio-KiqVoXvlOo6aKomL7Qz997gQMbB0uuF97nSnQ-iKkgdKWfEYTG07Yx9YzouCwhEaU6J4phiBYzQmBIpMEsFP0VkIG0JSpmCERgMfIz1Z29ZFr7tQ9ibWrsN1h-PaYqO9i3WJV67c4Sf8cY9N773tIm5d2Tc62pTt8Oec_XTsthZPsdlP89bYbXQeG9s04QKdVLoJ9nKo52jx-rKYvGez-dt08jzL1sDzmFFNrGaGlIYQKkBWMi8qwYUSVFcrLhgoBhykyqFSVCpgjBmd6xUUjFAD5-jud-zWu6_ehrhs67BfQHfW9WEpJDBFOByEwInKKciDkFHKmeR7ePMPblzvu3RsMuk4RmWe0PWA-lVry-XW1632u-XwiZTfDrkORjdV-oipwx8TaXXFBHwDp7mVNw</recordid><startdate>19880729</startdate><enddate>19880729</enddate><creator>LOPEZ-BARNEO, J</creator><creator>LOPEZ-LOPEZ, J. 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R</au><au>URENA, J</au><au>GONZALEZ, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemotransduction in the carotid body : K+ current modulated by PO2 in type I chemoreceptor cells</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1988-07-29</date><risdate>1988</risdate><volume>241</volume><issue>4865</issue><spage>580</spage><epage>582</epage><pages>580-582</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The ionic currents of carotid body type I cells and their possible involvement in the detection of oxygen tension (Po2) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can be altered by changes in PO2 was tested. The results show that type I cells have voltage-dependent sodium, calcium, and potassium channels. Sodium and calcium currents were unaffected by a decrease in PO2 from 150 to 10 millimeters of mercury, whereas, with the same experimental protocol, potassium currents were reversibly reduced by 25 to 50 percent. The effect of hypoxia was independent of internal adenosine triphosphate and calcium. Thus, ionic conductances, and particularly the O2-sensitive potassium current, play a key role in the transduction mechanism of arterial chemoreceptors.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>2456613</pmid><doi>10.1126/science.2456613</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1988-07, Vol.241 (4865), p.580-582 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Biological and medical sciences Blood Calcium - physiology Carotid Body - physiology Cells, Cultured Chemoreceptor Cells - physiology Electric Conductivity Fundamental and applied biological sciences. Psychology In Vitro Techniques Ion Channels - physiology Medical research Membrane Potentials Minerals Oxygen Oxygen - blood Potassium - physiology Rabbits Sodium - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | Chemotransduction in the carotid body : K+ current modulated by PO2 in type I chemoreceptor cells |
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