Studies on optimal dose and administration schedule of a hematopoietic stimulatory β-(1,4)-linked mannan
Several complex carbohydrates have been found to significantly stimulate hematopoiesis. CARN 750, a polydispersed β-(1,4)-linked acetylated mannan isolated from the Aloe vera plant, has been shown to have activity in wound repair, to function as a antineoplastic, and to activate macrophages. We repo...
Gespeichert in:
Veröffentlicht in: | International journal of immunopharmacology 1996-02, Vol.18 (2), p.113-126 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 126 |
---|---|
container_issue | 2 |
container_start_page | 113 |
container_title | International journal of immunopharmacology |
container_volume | 18 |
creator | Egger, Stefan F. Brown, Gregory S. Kelsey, Linda S. Yates, Kenneth M. Rosenberg, Larry J. Talmadge, James E. |
description | Several complex carbohydrates have been found to significantly stimulate hematopoiesis. CARN 750, a polydispersed β-(1,4)-linked acetylated mannan isolated from the
Aloe vera plant, has been shown to have activity in wound repair, to function as a antineoplastic, and to activate macrophages. We report, herein, the hematoaugmenting properties of CARN 750 and its optimal dose and timing of administration in an animal model of irradiation-induced myelosuppression. We observed that subcutaneous injections of 1 mg/animal of CARN 750 had equal or greater stimulatory activity for white blood cell (WBC) counts and spleen cellularity as well as on the absolute numbers of neutrophils, lymphocytes, monocytes and platelets than did higher or lower doses of CARN 750 or an optimal dose of granulocyte-colony stimulating factor (G-CSF). Hematopoietic progenitors, measured as interleukin-3-supported colony forming units-culture (CFU-C) and high proliferative potential colony-forming cells (HPP-CFC) assays, were similarly increased by CARN 750 in the spleen but not in the bone marrow. The frequency of splenic HPP-CFCs and absolute number of splenic HPP-CFCs and CFU-Cs were optimally increased by 1 mg/animal of CARN 750. In contrast, bone marrow cellularity, frequency and absolute number of HPP-CFCs and CFU-Cs had as a dosage optimum 2 mg/animal of CARN 750. These parameters were similarly increased by G-CSF. In studies to determine the optimal protocol for the administration of CARN 750 we found that the hematopoietic activity of CARN 750 increased with the frequency of administration. The greatest activity in myelosuppressed mice was observed for all hematopoietic parameters except the platelet number in mice receiving daily administration of 1 mg/animal of CARN 750 with activity equal to or greater than G-CSF. |
doi_str_mv | 10.1016/0192-0561(95)00112-3 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78326982</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0192056195001123</els_id><sourcerecordid>78326982</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-aa23a291e5d9d12d83d61928c798e7379e36f598df881ebc32bc095b7af8244c3</originalsourceid><addsrcrecordid>eNp9kMtqHDEQRYVJsMeO_yAGLUKwIe3o0Q9pEwgmLzBk4WQtaqRqrLhbGkvqgH8rH5JvsiYzzDIrQdW5F9Uh5DVn15zx_j3jWjSs6_ml7q4Y41w08oisuBp0I1vdvSCrA3JCTnP-xRjreC-OyXFltOz5ivi7sjiPmcZA46b4GSbqYkYKwVFwsw8-lwTF13229-iWCWkcKdB7nKHETfRYvKW5RpepDtIT_funueTv2qtm8uEBHZ0hBAivyMsRpozn-_eM_Pz86cfN1-b2-5dvNx9vGytVXxoAIUFojp3TjgunpOvrFcoOWuEgB42yHzut3KgUx7WVYm2Z7tYDjEq0rZVn5O2ud5Pi44K5mNlni9MEAeOSzaCk6LUSFWx3oE0x54Sj2aR6f3oynJmtYbPVZ7b6jO7MP8NG1tjFvn9Zz-gOob3Sun-z30O2MI0JgvX5gMnaovS25sMOw-rit8dksvUYLDqf0Bbjov__P54BTt-X7Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78326982</pqid></control><display><type>article</type><title>Studies on optimal dose and administration schedule of a hematopoietic stimulatory β-(1,4)-linked mannan</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Egger, Stefan F. ; Brown, Gregory S. ; Kelsey, Linda S. ; Yates, Kenneth M. ; Rosenberg, Larry J. ; Talmadge, James E.</creator><creatorcontrib>Egger, Stefan F. ; Brown, Gregory S. ; Kelsey, Linda S. ; Yates, Kenneth M. ; Rosenberg, Larry J. ; Talmadge, James E.</creatorcontrib><description>Several complex carbohydrates have been found to significantly stimulate hematopoiesis. CARN 750, a polydispersed β-(1,4)-linked acetylated mannan isolated from the
Aloe vera plant, has been shown to have activity in wound repair, to function as a antineoplastic, and to activate macrophages. We report, herein, the hematoaugmenting properties of CARN 750 and its optimal dose and timing of administration in an animal model of irradiation-induced myelosuppression. We observed that subcutaneous injections of 1 mg/animal of CARN 750 had equal or greater stimulatory activity for white blood cell (WBC) counts and spleen cellularity as well as on the absolute numbers of neutrophils, lymphocytes, monocytes and platelets than did higher or lower doses of CARN 750 or an optimal dose of granulocyte-colony stimulating factor (G-CSF). Hematopoietic progenitors, measured as interleukin-3-supported colony forming units-culture (CFU-C) and high proliferative potential colony-forming cells (HPP-CFC) assays, were similarly increased by CARN 750 in the spleen but not in the bone marrow. The frequency of splenic HPP-CFCs and absolute number of splenic HPP-CFCs and CFU-Cs were optimally increased by 1 mg/animal of CARN 750. In contrast, bone marrow cellularity, frequency and absolute number of HPP-CFCs and CFU-Cs had as a dosage optimum 2 mg/animal of CARN 750. These parameters were similarly increased by G-CSF. In studies to determine the optimal protocol for the administration of CARN 750 we found that the hematopoietic activity of CARN 750 increased with the frequency of administration. The greatest activity in myelosuppressed mice was observed for all hematopoietic parameters except the platelet number in mice receiving daily administration of 1 mg/animal of CARN 750 with activity equal to or greater than G-CSF.</description><identifier>ISSN: 0192-0561</identifier><identifier>EISSN: 1879-3495</identifier><identifier>DOI: 10.1016/0192-0561(95)00112-3</identifier><identifier>PMID: 8799361</identifier><identifier>CODEN: IJIMDS</identifier><language>eng</language><publisher>Oxford: Elsevier Science</publisher><subject>acetylated mannan ; administration schedule ; Animals ; biologic ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; bone marrow ; CFU-C ; dose ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Evaluation Studies as Topic ; Female ; Granulocyte Colony-Stimulating Factor - biosynthesis ; hematopoiesis ; Hematopoietic Stem Cells - cytology ; HPP-CFC ; Mannans - administration & dosage ; Medical sciences ; Mice ; myelosuppression ; peripheral blood ; Pharmacology. Drug treatments ; spleen</subject><ispartof>International journal of immunopharmacology, 1996-02, Vol.18 (2), p.113-126</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-aa23a291e5d9d12d83d61928c798e7379e36f598df881ebc32bc095b7af8244c3</citedby><cites>FETCH-LOGICAL-c386t-aa23a291e5d9d12d83d61928c798e7379e36f598df881ebc32bc095b7af8244c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3112893$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8799361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Egger, Stefan F.</creatorcontrib><creatorcontrib>Brown, Gregory S.</creatorcontrib><creatorcontrib>Kelsey, Linda S.</creatorcontrib><creatorcontrib>Yates, Kenneth M.</creatorcontrib><creatorcontrib>Rosenberg, Larry J.</creatorcontrib><creatorcontrib>Talmadge, James E.</creatorcontrib><title>Studies on optimal dose and administration schedule of a hematopoietic stimulatory β-(1,4)-linked mannan</title><title>International journal of immunopharmacology</title><addtitle>Int J Immunopharmacol</addtitle><description>Several complex carbohydrates have been found to significantly stimulate hematopoiesis. CARN 750, a polydispersed β-(1,4)-linked acetylated mannan isolated from the
Aloe vera plant, has been shown to have activity in wound repair, to function as a antineoplastic, and to activate macrophages. We report, herein, the hematoaugmenting properties of CARN 750 and its optimal dose and timing of administration in an animal model of irradiation-induced myelosuppression. We observed that subcutaneous injections of 1 mg/animal of CARN 750 had equal or greater stimulatory activity for white blood cell (WBC) counts and spleen cellularity as well as on the absolute numbers of neutrophils, lymphocytes, monocytes and platelets than did higher or lower doses of CARN 750 or an optimal dose of granulocyte-colony stimulating factor (G-CSF). Hematopoietic progenitors, measured as interleukin-3-supported colony forming units-culture (CFU-C) and high proliferative potential colony-forming cells (HPP-CFC) assays, were similarly increased by CARN 750 in the spleen but not in the bone marrow. The frequency of splenic HPP-CFCs and absolute number of splenic HPP-CFCs and CFU-Cs were optimally increased by 1 mg/animal of CARN 750. In contrast, bone marrow cellularity, frequency and absolute number of HPP-CFCs and CFU-Cs had as a dosage optimum 2 mg/animal of CARN 750. These parameters were similarly increased by G-CSF. In studies to determine the optimal protocol for the administration of CARN 750 we found that the hematopoietic activity of CARN 750 increased with the frequency of administration. The greatest activity in myelosuppressed mice was observed for all hematopoietic parameters except the platelet number in mice receiving daily administration of 1 mg/animal of CARN 750 with activity equal to or greater than G-CSF.</description><subject>acetylated mannan</subject><subject>administration schedule</subject><subject>Animals</subject><subject>biologic</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>bone marrow</subject><subject>CFU-C</subject><subject>dose</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Granulocyte Colony-Stimulating Factor - biosynthesis</subject><subject>hematopoiesis</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>HPP-CFC</subject><subject>Mannans - administration & dosage</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>myelosuppression</subject><subject>peripheral blood</subject><subject>Pharmacology. Drug treatments</subject><subject>spleen</subject><issn>0192-0561</issn><issn>1879-3495</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtqHDEQRYVJsMeO_yAGLUKwIe3o0Q9pEwgmLzBk4WQtaqRqrLhbGkvqgH8rH5JvsiYzzDIrQdW5F9Uh5DVn15zx_j3jWjSs6_ml7q4Y41w08oisuBp0I1vdvSCrA3JCTnP-xRjreC-OyXFltOz5ivi7sjiPmcZA46b4GSbqYkYKwVFwsw8-lwTF13229-iWCWkcKdB7nKHETfRYvKW5RpepDtIT_funueTv2qtm8uEBHZ0hBAivyMsRpozn-_eM_Pz86cfN1-b2-5dvNx9vGytVXxoAIUFojp3TjgunpOvrFcoOWuEgB42yHzut3KgUx7WVYm2Z7tYDjEq0rZVn5O2ud5Pi44K5mNlni9MEAeOSzaCk6LUSFWx3oE0x54Sj2aR6f3oynJmtYbPVZ7b6jO7MP8NG1tjFvn9Zz-gOob3Sun-z30O2MI0JgvX5gMnaovS25sMOw-rit8dksvUYLDqf0Bbjov__P54BTt-X7Q</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Egger, Stefan F.</creator><creator>Brown, Gregory S.</creator><creator>Kelsey, Linda S.</creator><creator>Yates, Kenneth M.</creator><creator>Rosenberg, Larry J.</creator><creator>Talmadge, James E.</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>Studies on optimal dose and administration schedule of a hematopoietic stimulatory β-(1,4)-linked mannan</title><author>Egger, Stefan F. ; Brown, Gregory S. ; Kelsey, Linda S. ; Yates, Kenneth M. ; Rosenberg, Larry J. ; Talmadge, James E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-aa23a291e5d9d12d83d61928c798e7379e36f598df881ebc32bc095b7af8244c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>acetylated mannan</topic><topic>administration schedule</topic><topic>Animals</topic><topic>biologic</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>bone marrow</topic><topic>CFU-C</topic><topic>dose</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Granulocyte Colony-Stimulating Factor - biosynthesis</topic><topic>hematopoiesis</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>HPP-CFC</topic><topic>Mannans - administration & dosage</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>myelosuppression</topic><topic>peripheral blood</topic><topic>Pharmacology. Drug treatments</topic><topic>spleen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Egger, Stefan F.</creatorcontrib><creatorcontrib>Brown, Gregory S.</creatorcontrib><creatorcontrib>Kelsey, Linda S.</creatorcontrib><creatorcontrib>Yates, Kenneth M.</creatorcontrib><creatorcontrib>Rosenberg, Larry J.</creatorcontrib><creatorcontrib>Talmadge, James E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Egger, Stefan F.</au><au>Brown, Gregory S.</au><au>Kelsey, Linda S.</au><au>Yates, Kenneth M.</au><au>Rosenberg, Larry J.</au><au>Talmadge, James E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on optimal dose and administration schedule of a hematopoietic stimulatory β-(1,4)-linked mannan</atitle><jtitle>International journal of immunopharmacology</jtitle><addtitle>Int J Immunopharmacol</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>18</volume><issue>2</issue><spage>113</spage><epage>126</epage><pages>113-126</pages><issn>0192-0561</issn><eissn>1879-3495</eissn><coden>IJIMDS</coden><abstract>Several complex carbohydrates have been found to significantly stimulate hematopoiesis. CARN 750, a polydispersed β-(1,4)-linked acetylated mannan isolated from the
Aloe vera plant, has been shown to have activity in wound repair, to function as a antineoplastic, and to activate macrophages. We report, herein, the hematoaugmenting properties of CARN 750 and its optimal dose and timing of administration in an animal model of irradiation-induced myelosuppression. We observed that subcutaneous injections of 1 mg/animal of CARN 750 had equal or greater stimulatory activity for white blood cell (WBC) counts and spleen cellularity as well as on the absolute numbers of neutrophils, lymphocytes, monocytes and platelets than did higher or lower doses of CARN 750 or an optimal dose of granulocyte-colony stimulating factor (G-CSF). Hematopoietic progenitors, measured as interleukin-3-supported colony forming units-culture (CFU-C) and high proliferative potential colony-forming cells (HPP-CFC) assays, were similarly increased by CARN 750 in the spleen but not in the bone marrow. The frequency of splenic HPP-CFCs and absolute number of splenic HPP-CFCs and CFU-Cs were optimally increased by 1 mg/animal of CARN 750. In contrast, bone marrow cellularity, frequency and absolute number of HPP-CFCs and CFU-Cs had as a dosage optimum 2 mg/animal of CARN 750. These parameters were similarly increased by G-CSF. In studies to determine the optimal protocol for the administration of CARN 750 we found that the hematopoietic activity of CARN 750 increased with the frequency of administration. The greatest activity in myelosuppressed mice was observed for all hematopoietic parameters except the platelet number in mice receiving daily administration of 1 mg/animal of CARN 750 with activity equal to or greater than G-CSF.</abstract><cop>Oxford</cop><pub>Elsevier Science</pub><pmid>8799361</pmid><doi>10.1016/0192-0561(95)00112-3</doi><tpages>14</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0192-0561 |
ispartof | International journal of immunopharmacology, 1996-02, Vol.18 (2), p.113-126 |
issn | 0192-0561 1879-3495 |
language | eng |
recordid | cdi_proquest_miscellaneous_78326982 |
source | MEDLINE; Alma/SFX Local Collection |
subjects | acetylated mannan administration schedule Animals biologic Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system bone marrow CFU-C dose Dose-Response Relationship, Drug Drug Administration Schedule Evaluation Studies as Topic Female Granulocyte Colony-Stimulating Factor - biosynthesis hematopoiesis Hematopoietic Stem Cells - cytology HPP-CFC Mannans - administration & dosage Medical sciences Mice myelosuppression peripheral blood Pharmacology. Drug treatments spleen |
title | Studies on optimal dose and administration schedule of a hematopoietic stimulatory β-(1,4)-linked mannan |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T15%3A22%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Studies%20on%20optimal%20dose%20and%20administration%20schedule%20of%20a%20hematopoietic%20stimulatory%20%CE%B2-(1,4)-linked%20mannan&rft.jtitle=International%20journal%20of%20immunopharmacology&rft.au=Egger,%20Stefan%20F.&rft.date=1996-02-01&rft.volume=18&rft.issue=2&rft.spage=113&rft.epage=126&rft.pages=113-126&rft.issn=0192-0561&rft.eissn=1879-3495&rft.coden=IJIMDS&rft_id=info:doi/10.1016/0192-0561(95)00112-3&rft_dat=%3Cproquest_cross%3E78326982%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78326982&rft_id=info:pmid/8799361&rft_els_id=0192056195001123&rfr_iscdi=true |