Vitamin K is no antagonist for the action of warfarin in rat osteosarcoma UMR 106
The recycling of vitamin K in the liver occurs via one or two dithiol-dependent reductases, which are strongly inhibited by coumarin derivatives such as warfarin. This inhibition may be partly overcome by the action of a NADU-dependent reductase, which is relatively insensitive for warfarin. In this...
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| Veröffentlicht in: | Thrombosis research 1988-04, Vol.50 (1), p.27-32 |
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| container_title | Thrombosis research |
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| creator | Ulrich, M.M.W Knapen, M.H.J Herrmann Erlee, M.P.M Vermeer, C |
| description | The recycling of vitamin K in the liver occurs via one or two dithiol-dependent reductases, which are strongly inhibited by coumarin derivatives such as warfarin. This inhibition may be partly overcome by the action of a NADU-dependent reductase, which is relatively insensitive for warfarin. In this paper we demonstrate that the osteoblast-like osteosarcoma UMR 106 does not contain the NADH-dependent reductase. Assuming that a similar enzyme distribution occurs in normal osteoblasts this explains the observation of Price and Kaneda [8], that the administration of vitamin K to rats efficiently counteracted the effect of warfarin on blood coagulation, but that the vitamin had no effect on the Gla-content of serum osteocalcin. |
| doi_str_mv | 10.1016/0049-3848(88)90171-5 |
| format | Article |
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This inhibition may be partly overcome by the action of a NADU-dependent reductase, which is relatively insensitive for warfarin. In this paper we demonstrate that the osteoblast-like osteosarcoma UMR 106 does not contain the NADH-dependent reductase. Assuming that a similar enzyme distribution occurs in normal osteoblasts this explains the observation of Price and Kaneda [8], that the administration of vitamin K to rats efficiently counteracted the effect of warfarin on blood coagulation, but that the vitamin had no effect on the Gla-content of serum osteocalcin.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>blood coagulation</subject><subject>Blood Coagulation - drug effects</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Carboxy-Lyases - metabolism</subject><subject>carboxylase</subject><subject>Liver - enzymology</subject><subject>Medical sciences</subject><subject>Microsomes - enzymology</subject><subject>osteocalcin</subject><subject>Osteosarcoma - enzymology</subject><subject>Oxidoreductases - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><subject>reductase</subject><subject>Tumor Cells, Cultured - drug effects</subject><subject>Tumor Cells, Cultured - enzymology</subject><subject>vitamin K</subject><subject>Vitamin K - pharmacology</subject><subject>warfarin</subject><subject>Warfarin - antagonists & inhibitors</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd9LHDEQgIMo52n9DxTyIEUftp3sJpvsi1DEX2gpLT1fQy47aSO3mzPJtfS_b8477tEQCMN8M8x8IeSUwScGrP0MwLuqUVxdKHXZAZOsEntkypTsqprLep9Md8ghOUrpBdZQJyZk0rBW1HU7Jd-ffTaDH-kj9YmOgZoxm19h9ClTFyLNv5Eam30YaXD0r4nOxEKXG02mIWUMyUQbBkNnX39QBu0HcuDMIuHJ9j0ms9ubn9f31dO3u4frL0-VbYDlqhPSAsoSuL5VnINkaMFwW0MvAObCCsFQYAeN41AWgR7tnLN550DJvmmOycdN32UMrytMWQ8-WVwszIhhlbRUTd0qAQXkG9DGkFJEp5fRDyb-0wz02qRea9JrTVop_WZSi1J2tu2_mg_Y74q26kr-fJs3yZqFi2a0Pu0wWU75hIJdbTAsLv54jDpZj6PF3ke0WffBvz_HfyP-jQg</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>Ulrich, M.M.W</creator><creator>Knapen, M.H.J</creator><creator>Herrmann Erlee, M.P.M</creator><creator>Vermeer, C</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880401</creationdate><title>Vitamin K is no antagonist for the action of warfarin in rat osteosarcoma UMR 106</title><author>Ulrich, M.M.W ; Knapen, M.H.J ; Herrmann Erlee, M.P.M ; Vermeer, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-957c0e7c30fd6844071ec0a4c20d500b5c551e5e903f400040decb41b9f087d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>blood coagulation</topic><topic>Blood Coagulation - drug effects</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Carboxy-Lyases - metabolism</topic><topic>carboxylase</topic><topic>Liver - enzymology</topic><topic>Medical sciences</topic><topic>Microsomes - enzymology</topic><topic>osteocalcin</topic><topic>Osteosarcoma - enzymology</topic><topic>Oxidoreductases - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><topic>reductase</topic><topic>Tumor Cells, Cultured - drug effects</topic><topic>Tumor Cells, Cultured - enzymology</topic><topic>vitamin K</topic><topic>Vitamin K - pharmacology</topic><topic>warfarin</topic><topic>Warfarin - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ulrich, M.M.W</creatorcontrib><creatorcontrib>Knapen, M.H.J</creatorcontrib><creatorcontrib>Herrmann Erlee, M.P.M</creatorcontrib><creatorcontrib>Vermeer, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ulrich, M.M.W</au><au>Knapen, M.H.J</au><au>Herrmann Erlee, M.P.M</au><au>Vermeer, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin K is no antagonist for the action of warfarin in rat osteosarcoma UMR 106</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>50</volume><issue>1</issue><spage>27</spage><epage>32</epage><pages>27-32</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>The recycling of vitamin K in the liver occurs via one or two dithiol-dependent reductases, which are strongly inhibited by coumarin derivatives such as warfarin. This inhibition may be partly overcome by the action of a NADU-dependent reductase, which is relatively insensitive for warfarin. In this paper we demonstrate that the osteoblast-like osteosarcoma UMR 106 does not contain the NADH-dependent reductase. Assuming that a similar enzyme distribution occurs in normal osteoblasts this explains the observation of Price and Kaneda [8], that the administration of vitamin K to rats efficiently counteracted the effect of warfarin on blood coagulation, but that the vitamin had no effect on the Gla-content of serum osteocalcin.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>3165226</pmid><doi>10.1016/0049-3848(88)90171-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | Thrombosis research, 1988-04, Vol.50 (1), p.27-32 |
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| language | eng |
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| subjects | Animals Biological and medical sciences blood coagulation Blood Coagulation - drug effects Blood. Blood coagulation. Reticuloendothelial system Carboxy-Lyases - metabolism carboxylase Liver - enzymology Medical sciences Microsomes - enzymology osteocalcin Osteosarcoma - enzymology Oxidoreductases - metabolism Pharmacology. Drug treatments Rats Rats, Inbred BN reductase Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - enzymology vitamin K Vitamin K - pharmacology warfarin Warfarin - antagonists & inhibitors |
| title | Vitamin K is no antagonist for the action of warfarin in rat osteosarcoma UMR 106 |
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