Up-regulation of D3 dopamine receptor mRNA by neuroleptics
The effects of 14 days neuroleptic treatment on the expression of the D3 dopamine receptor gene was investigated in rats using a sensitive polymerase chain reaction assay. In olfactory tubercle, D3 mRNA levels increased following haloperidol (40%), pimozide (56%), and sulpiride (63%) administration,...
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| Veröffentlicht in: | Synapse (New York, N.Y.) N.Y.), 1996-07, Vol.23 (3), p.232-235 |
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| container_title | Synapse (New York, N.Y.) |
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| creator | Wang, Wei Hahn, Kyu-Hee Bishop, John F. Gao, Da-Qing Jose, Pedro A. Mouradian, M. Maral |
| description | The effects of 14 days neuroleptic treatment on the expression of the D3 dopamine receptor gene was investigated in rats using a sensitive polymerase chain reaction assay. In olfactory tubercle, D3 mRNA levels increased following haloperidol (40%), pimozide (56%), and sulpiride (63%) administration, and in nucleus accumbens, levels increased after haloperidol (50%) and sulpiride (50%). D3 expression in the motor striatum did not change with any antagonist tested. Clozapine did not affect D3 expression in any brain region. These data suggest that dopamine antagonists can regulate the expression of the D3 receptor in a brain region selective manner. The findings also suggest that the motor complications of chronic antipsychotic therapy are not due to D3 receptor up‐regulation in the striatum. (This article is a US Government work and, as such, is in the public domain in the United States of America.) © 1996 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1098-2396(199607)23:3<232::AID-SYN13>3.0.CO;2-0 |
| format | Article |
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Maral</creatorcontrib><title>Up-regulation of D3 dopamine receptor mRNA by neuroleptics</title><title>Synapse (New York, N.Y.)</title><addtitle>Synapse</addtitle><description>The effects of 14 days neuroleptic treatment on the expression of the D3 dopamine receptor gene was investigated in rats using a sensitive polymerase chain reaction assay. In olfactory tubercle, D3 mRNA levels increased following haloperidol (40%), pimozide (56%), and sulpiride (63%) administration, and in nucleus accumbens, levels increased after haloperidol (50%) and sulpiride (50%). D3 expression in the motor striatum did not change with any antagonist tested. Clozapine did not affect D3 expression in any brain region. These data suggest that dopamine antagonists can regulate the expression of the D3 receptor in a brain region selective manner. The findings also suggest that the motor complications of chronic antipsychotic therapy are not due to D3 receptor up‐regulation in the striatum. (This article is a US Government work and, as such, is in the public domain in the United States of America.) © 1996 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>antipsychotic</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Brain Chemistry - drug effects</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>dopamine D3 receptor</subject><subject>Male</subject><subject>Neostriatum - drug effects</subject><subject>Neostriatum - metabolism</subject><subject>neuroleptic</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Olfactory Bulb - drug effects</subject><subject>Olfactory Bulb - metabolism</subject><subject>Oligonucleotide Probes</subject><subject>Polymerase Chain Reaction</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Dopamine D2 - biosynthesis</subject><subject>Receptors, Dopamine D3</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Up-Regulation - drug effects</subject><issn>0887-4476</issn><issn>1098-2396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF9v0zAUxS0EGt3gIyDlCW0PKde-TuyUP1KVwagorbSxIZ4sx71FGUmTxY2g3x6XVH0BiRfbOkc-5-jH2FsOYw4gXp3fzPLZBYdMxwKz9JxnWQrqQuAE3wgUk8l0dhnffFtwfIdjGOfL1yKGR2x0_PGYjUBrFUup0qfs1Pt7AEAO8oSdaA1KJWLEJrdt3NH3vrLbstlEzTq6xGjVtLYuNxR15KjdNl1UXy-mUbGLNtR3TRW00vln7MnaVp6eH-4zdvvh_Zf8YzxfXs3y6Tx2yFOMlSuEkKkqLCbkJLkMHVAhrV5J5JyElQmCVFoT6LDOpZBYsrawa8FXRHjGXg65bdc89OS3pi69o6qyG2p6b5RGIblSeBzgusb7jtam7cradjvDweyZGrNnavaEzJ6QGZiGt8FwBD8wNX-YBgFMvjTCQMh9cRjQFzWtjqkHiMG_G_yfZUW7v0r_0_mvykEIwfEQXPot_ToG2-6HSRWqxHxdXJl0_ul6oT4n5g5_A0Eqn74</recordid><startdate>199607</startdate><enddate>199607</enddate><creator>Wang, Wei</creator><creator>Hahn, Kyu-Hee</creator><creator>Bishop, John F.</creator><creator>Gao, Da-Qing</creator><creator>Jose, Pedro A.</creator><creator>Mouradian, M. 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Maral</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3163-7cb22467ba35ec4ec93c0eb4a8d4311e2a45304788e08104c605aeaabaf21dee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>antipsychotic</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Brain Chemistry - drug effects</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>dopamine D3 receptor</topic><topic>Male</topic><topic>Neostriatum - drug effects</topic><topic>Neostriatum - metabolism</topic><topic>neuroleptic</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Olfactory Bulb - drug effects</topic><topic>Olfactory Bulb - metabolism</topic><topic>Oligonucleotide Probes</topic><topic>Polymerase Chain Reaction</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Dopamine D2 - biosynthesis</topic><topic>Receptors, Dopamine D3</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Hahn, Kyu-Hee</creatorcontrib><creatorcontrib>Bishop, John F.</creatorcontrib><creatorcontrib>Gao, Da-Qing</creatorcontrib><creatorcontrib>Jose, Pedro A.</creatorcontrib><creatorcontrib>Mouradian, M. 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Maral</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Up-regulation of D3 dopamine receptor mRNA by neuroleptics</atitle><jtitle>Synapse (New York, N.Y.)</jtitle><addtitle>Synapse</addtitle><date>1996-07</date><risdate>1996</risdate><volume>23</volume><issue>3</issue><spage>232</spage><epage>235</epage><pages>232-235</pages><issn>0887-4476</issn><eissn>1098-2396</eissn><abstract>The effects of 14 days neuroleptic treatment on the expression of the D3 dopamine receptor gene was investigated in rats using a sensitive polymerase chain reaction assay. In olfactory tubercle, D3 mRNA levels increased following haloperidol (40%), pimozide (56%), and sulpiride (63%) administration, and in nucleus accumbens, levels increased after haloperidol (50%) and sulpiride (50%). D3 expression in the motor striatum did not change with any antagonist tested. Clozapine did not affect D3 expression in any brain region. These data suggest that dopamine antagonists can regulate the expression of the D3 receptor in a brain region selective manner. The findings also suggest that the motor complications of chronic antipsychotic therapy are not due to D3 receptor up‐regulation in the striatum. (This article is a US Government work and, as such, is in the public domain in the United States of America.) © 1996 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>8807752</pmid><doi>10.1002/(SICI)1098-2396(199607)23:3<232::AID-SYN13>3.0.CO;2-0</doi><tpages>4</tpages></addata></record> |
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| ispartof | Synapse (New York, N.Y.), 1996-07, Vol.23 (3), p.232-235 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals antipsychotic Antipsychotic Agents - pharmacology Brain Chemistry - drug effects Dopamine Antagonists - pharmacology dopamine D3 receptor Male Neostriatum - drug effects Neostriatum - metabolism neuroleptic Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Olfactory Bulb - drug effects Olfactory Bulb - metabolism Oligonucleotide Probes Polymerase Chain Reaction Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - biosynthesis Receptors, Dopamine D3 RNA, Messenger - biosynthesis Up-Regulation - drug effects |
| title | Up-regulation of D3 dopamine receptor mRNA by neuroleptics |
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