The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol
Summary We have studied the effect of combination antiemetic therapy (ondansetron and droperidol) with morphine delivered by patient‐controlled analgesia following major gynaecological surgery. Sixty patients were randomly allocated to one of three treatment regimens; ondansetron alone (4 mg bolus a...
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| Veröffentlicht in: | Anaesthesia 1996-08, Vol.51 (8), p.776-778 |
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| container_title | Anaesthesia |
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| creator | Wrench, I. J. Ward, J. E. H. Walder, A. D. Hobbs, G. J. |
| description | Summary
We have studied the effect of combination antiemetic therapy (ondansetron and droperidol) with morphine delivered by patient‐controlled analgesia following major gynaecological surgery. Sixty patients were randomly allocated to one of three treatment regimens; ondansetron alone (4 mg bolus and 0.13 mg.ml‐1 in the morphine solution), droperidol alone (1.25 mg bolus and 0.05 mg.ml‐1 in the morphine solution), or both drugs in combination. For the first 12 postoperative hours, patients receiving combination therapy experienced significantly less nausea than those receiving single antiemetic therapy (p < 0.001). There was no difference between the regimens from 12 to 18 h. We conclude that a combination of ondansetron and droperidol added to morphine in a patient‐controlled analgesia system reduces postoperative nausea to a greater extent than treatment with either drug alone following major gynaecological surgery. |
| doi_str_mv | 10.1111/j.1365-2044.1996.tb07895.x |
| format | Article |
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We have studied the effect of combination antiemetic therapy (ondansetron and droperidol) with morphine delivered by patient‐controlled analgesia following major gynaecological surgery. Sixty patients were randomly allocated to one of three treatment regimens; ondansetron alone (4 mg bolus and 0.13 mg.ml‐1 in the morphine solution), droperidol alone (1.25 mg bolus and 0.05 mg.ml‐1 in the morphine solution), or both drugs in combination. For the first 12 postoperative hours, patients receiving combination therapy experienced significantly less nausea than those receiving single antiemetic therapy (p < 0.001). There was no difference between the regimens from 12 to 18 h. We conclude that a combination of ondansetron and droperidol added to morphine in a patient‐controlled analgesia system reduces postoperative nausea to a greater extent than treatment with either drug alone following major gynaecological surgery.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.1996.tb07895.x</identifier><identifier>PMID: 8795324</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Analgesia, Patient-Controlled ; Antiemetics - therapeutic use ; Antiemetics; droperidol, ondansetron ; Biological and medical sciences ; Complications; nausea, vomiting ; Digestive system ; Droperidol - therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Medical sciences ; Middle Aged ; Morphine - administration & dosage ; Nausea - prevention & control ; Ondansetron - therapeutic use ; Patient‐controlled analgesia ; Pharmacology. Drug treatments ; Postoperative Complications - prevention & control ; Time Factors ; Vomiting - prevention & control</subject><ispartof>Anaesthesia, 1996-08, Vol.51 (8), p.776-778</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4946-9f362a3bf04478fe0e111bbc34064425fa2adbc5b1b2a077752a3bc1be9fc8a63</citedby><cites>FETCH-LOGICAL-c4946-9f362a3bf04478fe0e111bbc34064425fa2adbc5b1b2a077752a3bc1be9fc8a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.1996.tb07895.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.1996.tb07895.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3178687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8795324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wrench, I. J.</creatorcontrib><creatorcontrib>Ward, J. E. H.</creatorcontrib><creatorcontrib>Walder, A. D.</creatorcontrib><creatorcontrib>Hobbs, G. J.</creatorcontrib><title>The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
We have studied the effect of combination antiemetic therapy (ondansetron and droperidol) with morphine delivered by patient‐controlled analgesia following major gynaecological surgery. Sixty patients were randomly allocated to one of three treatment regimens; ondansetron alone (4 mg bolus and 0.13 mg.ml‐1 in the morphine solution), droperidol alone (1.25 mg bolus and 0.05 mg.ml‐1 in the morphine solution), or both drugs in combination. For the first 12 postoperative hours, patients receiving combination therapy experienced significantly less nausea than those receiving single antiemetic therapy (p < 0.001). There was no difference between the regimens from 12 to 18 h. We conclude that a combination of ondansetron and droperidol added to morphine in a patient‐controlled analgesia system reduces postoperative nausea to a greater extent than treatment with either drug alone following major gynaecological surgery.</description><subject>Adult</subject><subject>Analgesia, Patient-Controlled</subject><subject>Antiemetics - therapeutic use</subject><subject>Antiemetics; droperidol, ondansetron</subject><subject>Biological and medical sciences</subject><subject>Complications; nausea, vomiting</subject><subject>Digestive system</subject><subject>Droperidol - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morphine - administration & dosage</subject><subject>Nausea - prevention & control</subject><subject>Ondansetron - therapeutic use</subject><subject>Patient‐controlled analgesia</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Complications - prevention & control</subject><subject>Time Factors</subject><subject>Vomiting - prevention & control</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1u1DAUhS0EKkPhEZAihNgl-C-xwwaNqhaQqnZT1ta144BHiR3sZGjfvrEmzB4vbFnnnOvjD6EPBFdkXZ8PFWFNXVLMeUXatqlmjYVs6-rxBdqdpZdohzFmJeW4fY3epHTAmFBJ5AW6kKKtGeU7ZB9-22KK9mj97IIvQl9MIc1hshFmd7SFhyVZKMB3xTGMbnb-V7GkvENhwqidh3_B4Dvwyc5xvWZ_F_MY14XhLXrVw5Dsu-28RD9vrh-uvpe3999-XO1vS8Nb3pRtzxoKTPdreyF7i-36W60N47jhnNY9UOi0qTXRFLAQos5uQ7RteyOhYZfo02nuFMOfxaZZjS4ZOwzgbViSEpJRxplYjV9ORhNDStH2aopuhPikCFaZsTqoDFJlkCozVhtj9biG32-vLHq03Tm6QV31j5sOycDQR_DGpbONESEbmTt8Pdn-usE-_UcBtb_bXwvRsGdbjZtP</recordid><startdate>199608</startdate><enddate>199608</enddate><creator>Wrench, I. J.</creator><creator>Ward, J. E. H.</creator><creator>Walder, A. D.</creator><creator>Hobbs, G. J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199608</creationdate><title>The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol</title><author>Wrench, I. J. ; Ward, J. E. H. ; Walder, A. D. ; Hobbs, G. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4946-9f362a3bf04478fe0e111bbc34064425fa2adbc5b1b2a077752a3bc1be9fc8a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Analgesia, Patient-Controlled</topic><topic>Antiemetics - therapeutic use</topic><topic>Antiemetics; droperidol, ondansetron</topic><topic>Biological and medical sciences</topic><topic>Complications; nausea, vomiting</topic><topic>Digestive system</topic><topic>Droperidol - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Morphine - administration & dosage</topic><topic>Nausea - prevention & control</topic><topic>Ondansetron - therapeutic use</topic><topic>Patient‐controlled analgesia</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Complications - prevention & control</topic><topic>Time Factors</topic><topic>Vomiting - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wrench, I. J.</creatorcontrib><creatorcontrib>Ward, J. E. H.</creatorcontrib><creatorcontrib>Walder, A. D.</creatorcontrib><creatorcontrib>Hobbs, G. J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wrench, I. J.</au><au>Ward, J. E. H.</au><au>Walder, A. D.</au><au>Hobbs, G. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>1996-08</date><risdate>1996</risdate><volume>51</volume><issue>8</issue><spage>776</spage><epage>778</epage><pages>776-778</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
We have studied the effect of combination antiemetic therapy (ondansetron and droperidol) with morphine delivered by patient‐controlled analgesia following major gynaecological surgery. Sixty patients were randomly allocated to one of three treatment regimens; ondansetron alone (4 mg bolus and 0.13 mg.ml‐1 in the morphine solution), droperidol alone (1.25 mg bolus and 0.05 mg.ml‐1 in the morphine solution), or both drugs in combination. For the first 12 postoperative hours, patients receiving combination therapy experienced significantly less nausea than those receiving single antiemetic therapy (p < 0.001). There was no difference between the regimens from 12 to 18 h. We conclude that a combination of ondansetron and droperidol added to morphine in a patient‐controlled analgesia system reduces postoperative nausea to a greater extent than treatment with either drug alone following major gynaecological surgery.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8795324</pmid><doi>10.1111/j.1365-2044.1996.tb07895.x</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Analgesia, Patient-Controlled Antiemetics - therapeutic use Antiemetics droperidol, ondansetron Biological and medical sciences Complications nausea, vomiting Digestive system Droperidol - therapeutic use Drug Therapy, Combination Female Humans Medical sciences Middle Aged Morphine - administration & dosage Nausea - prevention & control Ondansetron - therapeutic use Patient‐controlled analgesia Pharmacology. Drug treatments Postoperative Complications - prevention & control Time Factors Vomiting - prevention & control |
| title | The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol |
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