Identification of lactams as in vitro metabolites of piperidine-type phenothiazine antipsychotic drugs

The metabolism of the piperidine-type phenothiazine antipsychotic agents thioridazine, mesoridazine and sulforidazine was studied in vitro with 10 000g liver supernatants obtained from rats and dogs. After incubations at 37°C for different time intervals, the incubates were extracted with dichlorome...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1996-04, Vol.14 (6), p.727-738
Hauptverfasser:	Lin, Ge, Chu, Ka-Wing, Damani, Lyaquatali A., Hawes, Edward M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - metabolism Antipsychotic Agents - pharmacokinetics Biological and medical sciences Biotransformation Chromatography, High Pressure Liquid Chromatography, Ion Exchange Dogs Female Humans In vitro metabolism In Vitro Techniques Lactam metabolites Lactams - analysis Lactams - metabolism Liver - metabolism Male Mass Spectrometry Medical sciences Mesoridazine Mesoridazine - pharmacokinetics Neuropharmacology Pharmacology. Drug treatments Phenothiazines - pharmacokinetics Piperidines - metabolism Piperidines - pharmacokinetics Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Sulforidazine Thioridazine Thioridazine - pharmacokinetics
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