Interstitial pneumonitis following autologous bone marrow transplantation
Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the...
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| Veröffentlicht in: | Transplantation 1988-07, Vol.46 (1), p.61-65 |
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| creator | WINGARD, J. R SOSTRIN, M. B VRIESENDORP, H. M MELLITS, E. D SANTOS, G. W FULLER, D. J BRAINE, H. G YEAGER, A. M BURNS, W. H SARAL, R |
| description | Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P less than or equal to 0.001 for both comparisons). |
| doi_str_mv | 10.1097/00007890-198807000-00010 |
| format | Article |
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R ; SOSTRIN, M. B ; VRIESENDORP, H. M ; MELLITS, E. D ; SANTOS, G. W ; FULLER, D. J ; BRAINE, H. G ; YEAGER, A. M ; BURNS, W. H ; SARAL, R</creator><creatorcontrib>WINGARD, J. R ; SOSTRIN, M. B ; VRIESENDORP, H. M ; MELLITS, E. D ; SANTOS, G. W ; FULLER, D. J ; BRAINE, H. G ; YEAGER, A. M ; BURNS, W. H ; SARAL, R</creatorcontrib><description>Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P less than or equal to 0.001 for both comparisons).</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-198807000-00010</identifier><identifier>PMID: 2839915</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Child ; Child, Preschool ; Cytomegalovirus Infections - complications ; Female ; Humans ; Leukemia - therapy ; Lymphoma - therapy ; Male ; Medical sciences ; Pulmonary Fibrosis - etiology ; Risk Factors ; Transfusions. Complications. Transfusion reactions. 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B</creatorcontrib><creatorcontrib>VRIESENDORP, H. M</creatorcontrib><creatorcontrib>MELLITS, E. D</creatorcontrib><creatorcontrib>SANTOS, G. W</creatorcontrib><creatorcontrib>FULLER, D. J</creatorcontrib><creatorcontrib>BRAINE, H. G</creatorcontrib><creatorcontrib>YEAGER, A. M</creatorcontrib><creatorcontrib>BURNS, W. H</creatorcontrib><creatorcontrib>SARAL, R</creatorcontrib><title>Interstitial pneumonitis following autologous bone marrow transplantation</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P less than or equal to 0.001 for both comparisons).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Female</subject><subject>Humans</subject><subject>Leukemia - therapy</subject><subject>Lymphoma - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pulmonary Fibrosis - etiology</subject><subject>Risk Factors</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Virus Diseases - complications</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN9LwzAQgIMoc07_BKEP4lv1rkma9FGGPwYDX_S5pFkyKmlTm5Thf290c68GQnLcd5fLR0iGcIdQiXtIS8gKcqykBJGiPG2EEzJHTllegoRTMgdgmCOl4pxchPCREE6FmJFZIWlVIZ-T1aqPZgyxja1y2dCbqfN9CkJmvXN-1_bbTE3RO7_1U8ga35usU-Pod1kcVR8Gp_qoYuv7S3JmlQvm6nAuyPvT49vyJV-_Pq-WD-tcM1nGXBtkRrCmKCXjyCsmjFQFWFpYjdqqJl0ZWNSbprCFaJiASitkZcNxw42lC3K77zuM_nMyIdZdG7RxaRCTRqyFpAWUQP8FkVWl4IwnUO5BPfoQRmPrYWzTJ79qhPpHd_2nuz7qrn91p9LrwxtT05nNsfDgN-VvDnkVtHI2KdNtOGICKBYA9BsyZIjY</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>WINGARD, J. R</creator><creator>SOSTRIN, M. B</creator><creator>VRIESENDORP, H. M</creator><creator>MELLITS, E. D</creator><creator>SANTOS, G. W</creator><creator>FULLER, D. J</creator><creator>BRAINE, H. G</creator><creator>YEAGER, A. M</creator><creator>BURNS, W. H</creator><creator>SARAL, R</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19880701</creationdate><title>Interstitial pneumonitis following autologous bone marrow transplantation</title><author>WINGARD, J. R ; SOSTRIN, M. B ; VRIESENDORP, H. M ; MELLITS, E. D ; SANTOS, G. W ; FULLER, D. J ; BRAINE, H. G ; YEAGER, A. M ; BURNS, W. H ; SARAL, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-ce14e74b2684515947e8a20f32fc1cfab0f340f1cdb2f27b4709ca146b51d5ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Female</topic><topic>Humans</topic><topic>Leukemia - therapy</topic><topic>Lymphoma - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pulmonary Fibrosis - etiology</topic><topic>Risk Factors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Virus Diseases - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WINGARD, J. R</creatorcontrib><creatorcontrib>SOSTRIN, M. B</creatorcontrib><creatorcontrib>VRIESENDORP, H. M</creatorcontrib><creatorcontrib>MELLITS, E. D</creatorcontrib><creatorcontrib>SANTOS, G. W</creatorcontrib><creatorcontrib>FULLER, D. J</creatorcontrib><creatorcontrib>BRAINE, H. G</creatorcontrib><creatorcontrib>YEAGER, A. M</creatorcontrib><creatorcontrib>BURNS, W. H</creatorcontrib><creatorcontrib>SARAL, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WINGARD, J. R</au><au>SOSTRIN, M. B</au><au>VRIESENDORP, H. M</au><au>MELLITS, E. D</au><au>SANTOS, G. W</au><au>FULLER, D. J</au><au>BRAINE, H. G</au><au>YEAGER, A. M</au><au>BURNS, W. H</au><au>SARAL, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interstitial pneumonitis following autologous bone marrow transplantation</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>46</volume><issue>1</issue><spage>61</spage><epage>65</epage><pages>61-65</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P less than or equal to 0.001 for both comparisons).</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>2839915</pmid><doi>10.1097/00007890-198807000-00010</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transplantation, 1988-07, Vol.46 (1), p.61-65 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Child Child, Preschool Cytomegalovirus Infections - complications Female Humans Leukemia - therapy Lymphoma - therapy Male Medical sciences Pulmonary Fibrosis - etiology Risk Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Virus Diseases - complications |
| title | Interstitial pneumonitis following autologous bone marrow transplantation |
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