The effect of age on calcium dynamics in rat brain in vivo

Different biochemical changes accompany development and ageing. However, the time frame for a particular biochemical change may be different than that for another. In the ageing brain, neurological deficits related to ageing have been suggested to be due to a breakdown of calcium (Ca + +) homeostasi...

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Veröffentlicht in:	Mechanisms of ageing and development 1996-07, Vol.88 (1), p.17-24
Hauptverfasser:	Das, Nirmalendu, Ghosh, Santibrata
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Sprache:	eng
Schlagworte:	Ageing Aging - metabolism Animals Biochemistry and metabolism Biological and medical sciences Brain Brain - metabolism Calcium - blood Calcium - metabolism Calcium homeostasis Central nervous system Computer Simulation Fundamental and applied biological sciences. Psychology Homeostasis Kinetic analysis Male Models, Biological Rat Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs
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container_title	Mechanisms of ageing and development
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creator	Das, Nirmalendu Ghosh, Santibrata
description	Different biochemical changes accompany development and ageing. However, the time frame for a particular biochemical change may be different than that for another. In the ageing brain, neurological deficits related to ageing have been suggested to be due to a breakdown of calcium (Ca + +) homeostasis, and an increase in intracellular Ca + +. To understand the dynamics of calcium in CNS in relation to normal ageing, we have determined 45Ca + + uptake by the different regions of brain in young (3 months) and aged (15 months) rats after a single i.v. injection of 90 μCi/kg 45Ca + +. In the aged group, the initial plasma contents of the tracer were higher than in the young rats (3 months). The mean values of uptake (as fraction of injected dose/g × 10 5) of 45Ca at different sites were higher in the 15-month-old animals than in the young rats (viz. cortex: 50 vs. 26; hippocampus: 90 vs. 46 and putamen: 54 vs. 30 at 120 min). Computer simulation of the uptake data indicated that the values of most of the fractional transport rates were similar or lower in the aged compared to the controls. However, the steady state ratio of intra/extracellular Ca + + was higher in the 15-month-old animals, suggestive of intracellular accumulation of Ca + +.
doi_str_mv	10.1016/0047-6374(96)01713-7
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Computer simulation of the uptake data indicated that the values of most of the fractional transport rates were similar or lower in the aged compared to the controls. However, the steady state ratio of intra/extracellular Ca + + was higher in the 15-month-old animals, suggestive of intracellular accumulation of Ca + +.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/0047-6374(96)01713-7</identifier><identifier>PMID: 8803919</identifier><identifier>CODEN: MAGDA3</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Ageing ; Aging - metabolism ; Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Brain ; Brain - metabolism ; Calcium - blood ; Calcium - metabolism ; Calcium homeostasis ; Central nervous system ; Computer Simulation ; Fundamental and applied biological sciences. 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However, the time frame for a particular biochemical change may be different than that for another. In the ageing brain, neurological deficits related to ageing have been suggested to be due to a breakdown of calcium (Ca + +) homeostasis, and an increase in intracellular Ca + +. To understand the dynamics of calcium in CNS in relation to normal ageing, we have determined 45Ca + + uptake by the different regions of brain in young (3 months) and aged (15 months) rats after a single i.v. injection of 90 μCi/kg 45Ca + +. In the aged group, the initial plasma contents of the tracer were higher than in the young rats (3 months). The mean values of uptake (as fraction of injected dose/g × 10 5) of 45Ca at different sites were higher in the 15-month-old animals than in the young rats (viz. cortex: 50 vs. 26; hippocampus: 90 vs. 46 and putamen: 54 vs. 30 at 120 min). Computer simulation of the uptake data indicated that the values of most of the fractional transport rates were similar or lower in the aged compared to the controls. However, the steady state ratio of intra/extracellular Ca + + was higher in the 15-month-old animals, suggestive of intracellular accumulation of Ca + +.</description><subject>Ageing</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Calcium - blood</subject><subject>Calcium - metabolism</subject><subject>Calcium homeostasis</subject><subject>Central nervous system</subject><subject>Computer Simulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Homeostasis</subject><subject>Kinetic analysis</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gUIOInpYzdcmGw-CFL-g4KWeQzY70Uh3V5O20H9vlpYehUAyzJN3hgehc0puKaHyjhChCsmVuNbyhlBFeaEO0JhWihWSUXmIxnvkGJ2k9E0IoYLJERpVFeGa6jG6n38BBu_BLXHvsf0E3HfY2YULqxY3m862wSUcOhztEtfR5lc-67DuT9GRt4sEZ7t7gj6en-bT12L2_vI2fZwVjldyWYBSQHhtS-3KkpFaK1ZKaZXgvmSS1Yo0nPm8DmOcCa04F942pW2IBmcrxSfoapv7E_vfFaSlaUNysFjYDvpVMqriVGtKMyi2oIt9ShG8-YmhtXFjKDGDMjP4MIMPo3MxKDND_sUuf1W30Ow_7Rzl_uWub1MW46PtXEh7jFMqpBimP2wxyC7WAaJJLkDnoAkx2zVNH_7f4w9fxIRl</recordid><startdate>19960705</startdate><enddate>19960705</enddate><creator>Das, Nirmalendu</creator><creator>Ghosh, Santibrata</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960705</creationdate><title>The effect of age on calcium dynamics in rat brain in vivo</title><author>Das, Nirmalendu ; Ghosh, Santibrata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-e77e03ba59c5520b972566a743f5262b70d32f0392232497334fad5ad09eca873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Ageing</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Calcium - blood</topic><topic>Calcium - metabolism</topic><topic>Calcium homeostasis</topic><topic>Central nervous system</topic><topic>Computer Simulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Homeostasis</topic><topic>Kinetic analysis</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Das, Nirmalendu</creatorcontrib><creatorcontrib>Ghosh, Santibrata</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Das, Nirmalendu</au><au>Ghosh, Santibrata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of age on calcium dynamics in rat brain in vivo</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>1996-07-05</date><risdate>1996</risdate><volume>88</volume><issue>1</issue><spage>17</spage><epage>24</epage><pages>17-24</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><coden>MAGDA3</coden><abstract>Different biochemical changes accompany development and ageing. However, the time frame for a particular biochemical change may be different than that for another. In the ageing brain, neurological deficits related to ageing have been suggested to be due to a breakdown of calcium (Ca + +) homeostasis, and an increase in intracellular Ca + +. To understand the dynamics of calcium in CNS in relation to normal ageing, we have determined 45Ca + + uptake by the different regions of brain in young (3 months) and aged (15 months) rats after a single i.v. injection of 90 μCi/kg 45Ca + +. In the aged group, the initial plasma contents of the tracer were higher than in the young rats (3 months). The mean values of uptake (as fraction of injected dose/g × 10 5) of 45Ca at different sites were higher in the 15-month-old animals than in the young rats (viz. cortex: 50 vs. 26; hippocampus: 90 vs. 46 and putamen: 54 vs. 30 at 120 min). Computer simulation of the uptake data indicated that the values of most of the fractional transport rates were similar or lower in the aged compared to the controls. However, the steady state ratio of intra/extracellular Ca + + was higher in the 15-month-old animals, suggestive of intracellular accumulation of Ca + +.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8803919</pmid><doi>10.1016/0047-6374(96)01713-7</doi><tpages>8</tpages></addata></record>
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subjects	Ageing Aging - metabolism Animals Biochemistry and metabolism Biological and medical sciences Brain Brain - metabolism Calcium - blood Calcium - metabolism Calcium homeostasis Central nervous system Computer Simulation Fundamental and applied biological sciences. Psychology Homeostasis Kinetic analysis Male Models, Biological Rat Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs
title	The effect of age on calcium dynamics in rat brain in vivo
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