Prevalence of hypopigmented macules in a healthy population
OBJECTIVE: Although hypopigmented macules are an important manifestation of tuberous sclerosis (TS), the probability of TS in healthy individuals who have hypopigmented macules is unknown. The purpose of this study was to establish the prevalence of hypopigmented macules among a cross section of the...
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| Veröffentlicht in: | The Journal of pediatrics 1996-09, Vol.129 (3), p.355-361 |
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| container_title | The Journal of pediatrics |
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| creator | Vanderhooft, Sheryll L. Francis, Julie S. Pagon, Roberta A. Smith, Lynne T. Sybert, Virginia P. |
| description | OBJECTIVE: Although hypopigmented macules are an important manifestation of tuberous sclerosis (TS), the probability of TS in healthy individuals who have hypopigmented macules is unknown. The purpose of this study was to establish the prevalence of hypopigmented macules among a cross section of the general white population.
STUDY DESIGN: The skin of 423 white individuals younger than 45 years of age was screened for hypopigmented macules with ambient incandescent and fluorescent light and a Wood lamp. Indirect ophthalmoscopy was performed in patients with unexplained hypopigmentation to screen for retinal manifestations of TS.
RESULTS: Twenty individuals (4.7%) had at least one hypopigmented macule. Of these, four had more than one macule. None had more than three. Two (8%) of the 25 hypopigmented macules were identified only with a Wood lamp. Indirect ophthalmoscopy was performed in 13 (65%) of these 20 individuals. None showed the retinal findings of TS.
CONCLUSIONS: The prevalence of hypopigmented macules in the general population has been underestimated. The presence of a few hypopigmented macules on the skin of an otherwise healthy individual without a family history of TS need not prompt an evaluation to rule out this disorder. (J P
EDIATR 1996;129:355-61) |
| doi_str_mv | 10.1016/S0022-3476(96)70066-5 |
| format | Article |
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STUDY DESIGN: The skin of 423 white individuals younger than 45 years of age was screened for hypopigmented macules with ambient incandescent and fluorescent light and a Wood lamp. Indirect ophthalmoscopy was performed in patients with unexplained hypopigmentation to screen for retinal manifestations of TS.
RESULTS: Twenty individuals (4.7%) had at least one hypopigmented macule. Of these, four had more than one macule. None had more than three. Two (8%) of the 25 hypopigmented macules were identified only with a Wood lamp. Indirect ophthalmoscopy was performed in 13 (65%) of these 20 individuals. None showed the retinal findings of TS.
CONCLUSIONS: The prevalence of hypopigmented macules in the general population has been underestimated. The presence of a few hypopigmented macules on the skin of an otherwise healthy individual without a family history of TS need not prompt an evaluation to rule out this disorder. (J P
EDIATR 1996;129:355-61)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(96)70066-5</identifier><identifier>PMID: 8804323</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Child ; Child, Preschool ; Dermatology ; Female ; Humans ; Hypopigmentation - complications ; Hypopigmentation - epidemiology ; Hypopigmentation - pathology ; Infant ; Male ; Medical sciences ; Pigmentary diseases of the skin ; Prevalence ; Tuberous Sclerosis - complications ; Tuberous Sclerosis - diagnosis</subject><ispartof>The Journal of pediatrics, 1996-09, Vol.129 (3), p.355-361</ispartof><rights>1996 Mosby, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-7daec968ea1ee8e8b2914fb982e83e2528dba9b1e23e894e995ce86f3eb962f53</citedby><cites>FETCH-LOGICAL-c389t-7daec968ea1ee8e8b2914fb982e83e2528dba9b1e23e894e995ce86f3eb962f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(96)70066-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3225623$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8804323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanderhooft, Sheryll L.</creatorcontrib><creatorcontrib>Francis, Julie S.</creatorcontrib><creatorcontrib>Pagon, Roberta A.</creatorcontrib><creatorcontrib>Smith, Lynne T.</creatorcontrib><creatorcontrib>Sybert, Virginia P.</creatorcontrib><title>Prevalence of hypopigmented macules in a healthy population</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>OBJECTIVE: Although hypopigmented macules are an important manifestation of tuberous sclerosis (TS), the probability of TS in healthy individuals who have hypopigmented macules is unknown. The purpose of this study was to establish the prevalence of hypopigmented macules among a cross section of the general white population.
STUDY DESIGN: The skin of 423 white individuals younger than 45 years of age was screened for hypopigmented macules with ambient incandescent and fluorescent light and a Wood lamp. Indirect ophthalmoscopy was performed in patients with unexplained hypopigmentation to screen for retinal manifestations of TS.
RESULTS: Twenty individuals (4.7%) had at least one hypopigmented macule. Of these, four had more than one macule. None had more than three. Two (8%) of the 25 hypopigmented macules were identified only with a Wood lamp. Indirect ophthalmoscopy was performed in 13 (65%) of these 20 individuals. None showed the retinal findings of TS.
CONCLUSIONS: The prevalence of hypopigmented macules in the general population has been underestimated. The presence of a few hypopigmented macules on the skin of an otherwise healthy individual without a family history of TS need not prompt an evaluation to rule out this disorder. (J P
EDIATR 1996;129:355-61)</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypopigmentation - complications</subject><subject>Hypopigmentation - epidemiology</subject><subject>Hypopigmentation - pathology</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pigmentary diseases of the skin</subject><subject>Prevalence</subject><subject>Tuberous Sclerosis - complications</subject><subject>Tuberous Sclerosis - diagnosis</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMo4zj6CEIXIrqo5tKmCS5EBm8woKCuQ5qeOpH0YtIOzNvbzgyzdXUW_3fOf_gQOif4hmDCbz8wpjRmScavJL_OMOY8Tg_QlGCZxVwwdoime-QYnYTwgzGWCcYTNBECJ4yyKbp797DSDmoDUVNGy3XbtPa7grqDIqq06R2EyNaRjpagXbdcRwPQO93Zpj5FR6V2Ac52c4a-nh4_5y_x4u35df6wiA0TsouzQoORXIAmAAJETiVJylwKCoIBTakoci1zApSBkAlImRoQvGSQS07LlM3Q5fZu65vfHkKnKhsMOKdraPqgMsGIFAQPYLoFjW9C8FCq1ttK-7UiWI3S1EaaGo0oydVGmhoLzncFfV5Bsd_aWRryi12ug9Gu9Lo2NuwxRmnKN9j9FoNBxsqCV8HY0WxhPZhOFY3955E_fQSIyA</recordid><startdate>19960901</startdate><enddate>19960901</enddate><creator>Vanderhooft, Sheryll L.</creator><creator>Francis, Julie S.</creator><creator>Pagon, Roberta A.</creator><creator>Smith, Lynne T.</creator><creator>Sybert, Virginia P.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960901</creationdate><title>Prevalence of hypopigmented macules in a healthy population</title><author>Vanderhooft, Sheryll L. ; Francis, Julie S. ; Pagon, Roberta A. ; Smith, Lynne T. ; Sybert, Virginia P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-7daec968ea1ee8e8b2914fb982e83e2528dba9b1e23e894e995ce86f3eb962f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypopigmentation - complications</topic><topic>Hypopigmentation - epidemiology</topic><topic>Hypopigmentation - pathology</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pigmentary diseases of the skin</topic><topic>Prevalence</topic><topic>Tuberous Sclerosis - complications</topic><topic>Tuberous Sclerosis - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanderhooft, Sheryll L.</creatorcontrib><creatorcontrib>Francis, Julie S.</creatorcontrib><creatorcontrib>Pagon, Roberta A.</creatorcontrib><creatorcontrib>Smith, Lynne T.</creatorcontrib><creatorcontrib>Sybert, Virginia P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanderhooft, Sheryll L.</au><au>Francis, Julie S.</au><au>Pagon, Roberta A.</au><au>Smith, Lynne T.</au><au>Sybert, Virginia P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of hypopigmented macules in a healthy population</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>129</volume><issue>3</issue><spage>355</spage><epage>361</epage><pages>355-361</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>OBJECTIVE: Although hypopigmented macules are an important manifestation of tuberous sclerosis (TS), the probability of TS in healthy individuals who have hypopigmented macules is unknown. The purpose of this study was to establish the prevalence of hypopigmented macules among a cross section of the general white population.
STUDY DESIGN: The skin of 423 white individuals younger than 45 years of age was screened for hypopigmented macules with ambient incandescent and fluorescent light and a Wood lamp. Indirect ophthalmoscopy was performed in patients with unexplained hypopigmentation to screen for retinal manifestations of TS.
RESULTS: Twenty individuals (4.7%) had at least one hypopigmented macule. Of these, four had more than one macule. None had more than three. Two (8%) of the 25 hypopigmented macules were identified only with a Wood lamp. Indirect ophthalmoscopy was performed in 13 (65%) of these 20 individuals. None showed the retinal findings of TS.
CONCLUSIONS: The prevalence of hypopigmented macules in the general population has been underestimated. The presence of a few hypopigmented macules on the skin of an otherwise healthy individual without a family history of TS need not prompt an evaluation to rule out this disorder. (J P
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| ispartof | The Journal of pediatrics, 1996-09, Vol.129 (3), p.355-361 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Biological and medical sciences Child Child, Preschool Dermatology Female Humans Hypopigmentation - complications Hypopigmentation - epidemiology Hypopigmentation - pathology Infant Male Medical sciences Pigmentary diseases of the skin Prevalence Tuberous Sclerosis - complications Tuberous Sclerosis - diagnosis |
| title | Prevalence of hypopigmented macules in a healthy population |
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