Phosphorylation of HIV-1 Rev Protein: Implication of Protein Kinase CK2 and Pro-Directed Kinases

HIV-1 Rev transactivator is readily phosphorylated at separate regions by protein kinase CK2 and MAP kinase. Protein kinase CK1 cannot replace CK2 as phosphorylating agent and cdc2 only slowly phosphorylates Rev at one of the two sites affected by MAP kinase. Mutational analysis shows that Ser-8 and...

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Veröffentlicht in:	Biochemical and biophysical research communications 1996-09, Vol.226 (2), p.547-554
Hauptverfasser:	Meggio, Flavio, D'Agostino, Donna M., Ciminale, Vincenzo, Chieco-Bianchi, Luigi, Pinna, Lorenzo A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Casein Kinase II Gene Products, rev - metabolism HeLa Cells HIV-1 - metabolism Humans Molecular Sequence Data Peptide Fragments - metabolism Peptide Mapping Phosphorylation Protein-Serine-Threonine Kinases - metabolism rev Gene Products, Human Immunodeficiency Virus
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