Dosage and Timing of Anti-TNF-α Antibody Treatment Determine Its Effect on Resistance to Sepsis after Injury

Antibody against tumor necrosis factor-α (TNF-α) has improved survival in certain models of sepsis, but it remains unproven in clinical studies. In most of the successful animal studies, efficacy has been shown in previously healthy animals subjected to a septic challenge. Patients at risk for sepsi...

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