The mechanisms of peptide exchange and beta 2-microglobulin exchange on cell surface Ld and Kb molecules are noncooperative

It has previously been shown that the presence of exogenous beta 2-microglobulin (beta 2m) can dramatically enhance the binding of exogenous peptide to cell surface class I MHC. However, the mechanism by which this enhancement takes place is unknown. Two models have been proposed to explain this phe...

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Veröffentlicht in:	The Journal of immunology (1950) 1996-09, Vol.157 (6), p.2256-2261
Hauptverfasser:	Cook, JR, Myers, NB, Hansen, TH
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta 2-Microglobulin - antagonists & inhibitors beta 2-Microglobulin - metabolism beta 2-Microglobulin - pharmacology Cell Division - immunology H-2 Antigens - drug effects H-2 Antigens - metabolism Histocompatibility Antigen H-2D L Cells (Cell Line) Membrane Proteins - metabolism Mice Peptides - antagonists & inhibitors Peptides - metabolism Protein Binding - drug effects Protein Binding - immunology
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