Indirect computed tomography lymphography using iodinated nanoparticles to detect cancerous lymph nodes in a cutaneous melanoma model
To evaluate differences in contrast uptake in normal and cancerous lymph nodes on indirect computed tomography (CT) in swine, we conducted lymphographic examinations after subcutaneous injection Of a lymphotropic iodinated nanoparticle suspension. Perilesional subcutaneous contrast injections (2 ml...
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| Veröffentlicht in: | Academic radiology 1996, Vol.3 (1), p.40-48 |
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| creator | Wisner, Erik R. Katzberg, Richard W. Link, Daniel P. Griffey, Stephen M. Drake, Christiana M. Vessey, Adele R. Johnson, David Haley, Patrick J. |
| description | To evaluate differences in contrast uptake in normal and cancerous lymph nodes on indirect computed tomography (CT) in swine, we conducted lymphographic examinations after subcutaneous injection Of a lymphotropic iodinated nanoparticle suspension.
Perilesional subcutaneous contrast injections (2 ml per lesion) of a 15% wt/vol iodinated nanoparticle suspension were made in immature Sinclair miniature swine (
n = 5) with cutaneous melanomas. Average attenuation, iodine concentration, node volume, and total iodine uptake were estimated on the CT scans for each opacified lymph node 24 hr after injection. Nodes were classified as normal or cancerous microscopically, and the percentage of tumor replacement was estimated in cancerous nodes.
Average attenuation and iodine concentration were higher in normal nodes, and total iodine uptake was higher in cancerous nodes with greater than 25% replacement (
p < .05). Architectural alterations in opacifled cancerous nodes included medullary filling defects, expansile cortical lesions, and disruption of corticomedullary junctions.
Quantitative and qualitative differences in iodinated nanoparticle enhancement characteristics are useful in distinguishing between normal and cancerous lymph nodes on indirect CT lymphography examinations. |
| doi_str_mv | 10.1016/S1076-6332(96)80331-X |
| format | Article |
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Perilesional subcutaneous contrast injections (2 ml per lesion) of a 15% wt/vol iodinated nanoparticle suspension were made in immature Sinclair miniature swine (
n = 5) with cutaneous melanomas. Average attenuation, iodine concentration, node volume, and total iodine uptake were estimated on the CT scans for each opacified lymph node 24 hr after injection. Nodes were classified as normal or cancerous microscopically, and the percentage of tumor replacement was estimated in cancerous nodes.
Average attenuation and iodine concentration were higher in normal nodes, and total iodine uptake was higher in cancerous nodes with greater than 25% replacement (
p < .05). Architectural alterations in opacifled cancerous nodes included medullary filling defects, expansile cortical lesions, and disruption of corticomedullary junctions.
Quantitative and qualitative differences in iodinated nanoparticle enhancement characteristics are useful in distinguishing between normal and cancerous lymph nodes on indirect CT lymphography examinations.</description><identifier>ISSN: 1076-6332</identifier><identifier>EISSN: 1878-4046</identifier><identifier>DOI: 10.1016/S1076-6332(96)80331-X</identifier><identifier>PMID: 8796639</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Computed tomography ; Contrast Media ; Diatrizoate ; indirect lymphography ; iodinated nanoparticles ; Iodine ; Lymph Nodes - diagnostic imaging ; Lymphatic Metastasis ; Lymphography ; melanoma ; Melanoma, Experimental - diagnostic imaging ; Melanoma, Experimental - secondary ; Sensitivity and Specificity ; Skin Neoplasms - pathology ; Swine ; Swine, Miniature ; Tomography, X-Ray Computed - methods</subject><ispartof>Academic radiology, 1996, Vol.3 (1), p.40-48</ispartof><rights>1995 Association of University Radiologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-a87a45ee885242053d4102ebcb23a95b32ba27ab87eb79f86df9ae11ad8c15863</citedby><cites>FETCH-LOGICAL-c391t-a87a45ee885242053d4102ebcb23a95b32ba27ab87eb79f86df9ae11ad8c15863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1076-6332(96)80331-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27928,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8796639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wisner, Erik R.</creatorcontrib><creatorcontrib>Katzberg, Richard W.</creatorcontrib><creatorcontrib>Link, Daniel P.</creatorcontrib><creatorcontrib>Griffey, Stephen M.</creatorcontrib><creatorcontrib>Drake, Christiana M.</creatorcontrib><creatorcontrib>Vessey, Adele R.</creatorcontrib><creatorcontrib>Johnson, David</creatorcontrib><creatorcontrib>Haley, Patrick J.</creatorcontrib><title>Indirect computed tomography lymphography using iodinated nanoparticles to detect cancerous lymph nodes in a cutaneous melanoma model</title><title>Academic radiology</title><addtitle>Acad Radiol</addtitle><description>To evaluate differences in contrast uptake in normal and cancerous lymph nodes on indirect computed tomography (CT) in swine, we conducted lymphographic examinations after subcutaneous injection Of a lymphotropic iodinated nanoparticle suspension.
Perilesional subcutaneous contrast injections (2 ml per lesion) of a 15% wt/vol iodinated nanoparticle suspension were made in immature Sinclair miniature swine (
n = 5) with cutaneous melanomas. Average attenuation, iodine concentration, node volume, and total iodine uptake were estimated on the CT scans for each opacified lymph node 24 hr after injection. Nodes were classified as normal or cancerous microscopically, and the percentage of tumor replacement was estimated in cancerous nodes.
Average attenuation and iodine concentration were higher in normal nodes, and total iodine uptake was higher in cancerous nodes with greater than 25% replacement (
p < .05). Architectural alterations in opacifled cancerous nodes included medullary filling defects, expansile cortical lesions, and disruption of corticomedullary junctions.
Quantitative and qualitative differences in iodinated nanoparticle enhancement characteristics are useful in distinguishing between normal and cancerous lymph nodes on indirect CT lymphography examinations.</description><subject>Animals</subject><subject>Computed tomography</subject><subject>Contrast Media</subject><subject>Diatrizoate</subject><subject>indirect lymphography</subject><subject>iodinated nanoparticles</subject><subject>Iodine</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymphatic Metastasis</subject><subject>Lymphography</subject><subject>melanoma</subject><subject>Melanoma, Experimental - diagnostic imaging</subject><subject>Melanoma, Experimental - secondary</subject><subject>Sensitivity and Specificity</subject><subject>Skin Neoplasms - pathology</subject><subject>Swine</subject><subject>Swine, Miniature</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1076-6332</issn><issn>1878-4046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1q3TAQhUVpSNO0jxDQqrQLN_qxZWlVSuhPIJBFW8hOyNLcRMWSXMku3Afoe0e-vuk2q9FwzpkR8yF0QclHSqi4_EFJLxrBOXuvxAdJOKfN3Qt0RmUvm5a04mV9P1leodel_CaEdkLyU3QqeyUEV2fo33V0PoOdsU1hWmZweE4h3WczPezxuA_Tw1OzFB_vsU_OR7P6oolpMnn2doRSU9jBfBhkooWclrLFcUyu6j5ig-0ymwirFGCs8WBwqOr4Bp3szFjg7bGeo19fv_y8-t7c3H67vvp801iu6NwY2Zu2A5CyYy0jHXctJQwGOzBuVDdwNhjWm0H2MPRqJ4XbKQOUGict7aTg5-jdNnfK6c8CZdbBFwvjuP1K95JTwVn3rJEzojhTq7HbjDanUjLs9JR9MHmvKdErJ33gpFcIWgl94KTvau7iuGAZArj_qSOYqn_adKjn-Osh62I91MNutLRL_pkNj1Zxpmw</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Wisner, Erik R.</creator><creator>Katzberg, Richard W.</creator><creator>Link, Daniel P.</creator><creator>Griffey, Stephen M.</creator><creator>Drake, Christiana M.</creator><creator>Vessey, Adele R.</creator><creator>Johnson, David</creator><creator>Haley, Patrick J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Indirect computed tomography lymphography using iodinated nanoparticles to detect cancerous lymph nodes in a cutaneous melanoma model</title><author>Wisner, Erik R. ; Katzberg, Richard W. ; Link, Daniel P. ; Griffey, Stephen M. ; Drake, Christiana M. ; Vessey, Adele R. ; Johnson, David ; Haley, Patrick J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-a87a45ee885242053d4102ebcb23a95b32ba27ab87eb79f86df9ae11ad8c15863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Computed tomography</topic><topic>Contrast Media</topic><topic>Diatrizoate</topic><topic>indirect lymphography</topic><topic>iodinated nanoparticles</topic><topic>Iodine</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Lymphatic Metastasis</topic><topic>Lymphography</topic><topic>melanoma</topic><topic>Melanoma, Experimental - diagnostic imaging</topic><topic>Melanoma, Experimental - secondary</topic><topic>Sensitivity and Specificity</topic><topic>Skin Neoplasms - pathology</topic><topic>Swine</topic><topic>Swine, Miniature</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wisner, Erik R.</creatorcontrib><creatorcontrib>Katzberg, Richard W.</creatorcontrib><creatorcontrib>Link, Daniel P.</creatorcontrib><creatorcontrib>Griffey, Stephen M.</creatorcontrib><creatorcontrib>Drake, Christiana M.</creatorcontrib><creatorcontrib>Vessey, Adele R.</creatorcontrib><creatorcontrib>Johnson, David</creatorcontrib><creatorcontrib>Haley, Patrick J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Academic radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wisner, Erik R.</au><au>Katzberg, Richard W.</au><au>Link, Daniel P.</au><au>Griffey, Stephen M.</au><au>Drake, Christiana M.</au><au>Vessey, Adele R.</au><au>Johnson, David</au><au>Haley, Patrick J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indirect computed tomography lymphography using iodinated nanoparticles to detect cancerous lymph nodes in a cutaneous melanoma model</atitle><jtitle>Academic radiology</jtitle><addtitle>Acad Radiol</addtitle><date>1996</date><risdate>1996</risdate><volume>3</volume><issue>1</issue><spage>40</spage><epage>48</epage><pages>40-48</pages><issn>1076-6332</issn><eissn>1878-4046</eissn><abstract>To evaluate differences in contrast uptake in normal and cancerous lymph nodes on indirect computed tomography (CT) in swine, we conducted lymphographic examinations after subcutaneous injection Of a lymphotropic iodinated nanoparticle suspension.
Perilesional subcutaneous contrast injections (2 ml per lesion) of a 15% wt/vol iodinated nanoparticle suspension were made in immature Sinclair miniature swine (
n = 5) with cutaneous melanomas. Average attenuation, iodine concentration, node volume, and total iodine uptake were estimated on the CT scans for each opacified lymph node 24 hr after injection. Nodes were classified as normal or cancerous microscopically, and the percentage of tumor replacement was estimated in cancerous nodes.
Average attenuation and iodine concentration were higher in normal nodes, and total iodine uptake was higher in cancerous nodes with greater than 25% replacement (
p < .05). Architectural alterations in opacifled cancerous nodes included medullary filling defects, expansile cortical lesions, and disruption of corticomedullary junctions.
Quantitative and qualitative differences in iodinated nanoparticle enhancement characteristics are useful in distinguishing between normal and cancerous lymph nodes on indirect CT lymphography examinations.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8796639</pmid><doi>10.1016/S1076-6332(96)80331-X</doi><tpages>9</tpages></addata></record> |
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| ispartof | Academic radiology, 1996, Vol.3 (1), p.40-48 |
| issn | 1076-6332 1878-4046 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Computed tomography Contrast Media Diatrizoate indirect lymphography iodinated nanoparticles Iodine Lymph Nodes - diagnostic imaging Lymphatic Metastasis Lymphography melanoma Melanoma, Experimental - diagnostic imaging Melanoma, Experimental - secondary Sensitivity and Specificity Skin Neoplasms - pathology Swine Swine, Miniature Tomography, X-Ray Computed - methods |
| title | Indirect computed tomography lymphography using iodinated nanoparticles to detect cancerous lymph nodes in a cutaneous melanoma model |
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