Effect of vagotomy and atropine on plasma somatostatin response to a meal in conscious dogs
In 4 conscious dogs with gastric fistulas the somatostatin responses to a meal were measured and compared to the responses seen after i.v. infusion of atropine sulfate (20 and 50 μg · kg −1 · h −1) or cimetidine (8 mg · kg −1 · h −1). The experiments were repeated after truncal vagotomy. The somatos...
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| Veröffentlicht in: | Regulatory peptides 1988-05, Vol.21 (1), p.29-36 |
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| creator | Woussen-Colle, Marie-Claire Lalieu, Christine Simoens, Christian De Graef, Jacques |
| description | In 4 conscious dogs with gastric fistulas the somatostatin responses to a meal were measured and compared to the responses seen after i.v. infusion of atropine sulfate (20 and 50 μg · kg
−1 · h
−1) or cimetidine (8 mg · kg
−1 · h
−1). The experiments were repeated after truncal vagotomy. The somatostatin responses to bombesin (0.5 μ · kg
−1 · h
−1) were also measured before and after vagotomy. Vagotomy decreased basal and postprandial somatostatin levels and reduced the somatostatin responses to feeding during the first 30-min period following the ingestion of the meal but not during subsequent periods. Bombesin-induced somatostatin release was increased after vagotomy. Atropine decreased the somatostatin responses to the meal before and after vagotomy. Cimetidine had no significant effect. These studies suggest that, in conscious dogs, somatostatin released into the circulation is partly under vagal control and that, as for gastrin release, vagal pathways for stimulation and inhibition are present. Our studies also suggest that cholinergic mechanisms are involved in the control of postprandial somatostatin release. |
| doi_str_mv | 10.1016/0167-0115(88)90088-2 |
| format | Article |
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−1 · h
−1) or cimetidine (8 mg · kg
−1 · h
−1). The experiments were repeated after truncal vagotomy. The somatostatin responses to bombesin (0.5 μ · kg
−1 · h
−1) were also measured before and after vagotomy. Vagotomy decreased basal and postprandial somatostatin levels and reduced the somatostatin responses to feeding during the first 30-min period following the ingestion of the meal but not during subsequent periods. Bombesin-induced somatostatin release was increased after vagotomy. Atropine decreased the somatostatin responses to the meal before and after vagotomy. Cimetidine had no significant effect. These studies suggest that, in conscious dogs, somatostatin released into the circulation is partly under vagal control and that, as for gastrin release, vagal pathways for stimulation and inhibition are present. Our studies also suggest that cholinergic mechanisms are involved in the control of postprandial somatostatin release.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(88)90088-2</identifier><identifier>PMID: 2899334</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Atropine - pharmacology ; Biological and medical sciences ; Bombesin ; Bombesin - pharmacology ; Cimetidine ; Cimetidine - pharmacology ; Dogs ; Eating ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gastric Acid - metabolism ; Gastric Mucosa - drug effects ; Insulin - pharmacology ; Reference Values ; Somatostatin - blood ; Somatostatin - metabolism ; Vagal cholinergic ; Vagotomy ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Regulatory peptides, 1988-05, Vol.21 (1), p.29-36</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-5c306e31694a59474e7222b7fcfea105fe7cae006df6a621baaab3be6a49cf923</citedby><cites>FETCH-LOGICAL-c386t-5c306e31694a59474e7222b7fcfea105fe7cae006df6a621baaab3be6a49cf923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0167011588900882$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7079176$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2899334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woussen-Colle, Marie-Claire</creatorcontrib><creatorcontrib>Lalieu, Christine</creatorcontrib><creatorcontrib>Simoens, Christian</creatorcontrib><creatorcontrib>De Graef, Jacques</creatorcontrib><title>Effect of vagotomy and atropine on plasma somatostatin response to a meal in conscious dogs</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>In 4 conscious dogs with gastric fistulas the somatostatin responses to a meal were measured and compared to the responses seen after i.v. infusion of atropine sulfate (20 and 50 μg · kg
−1 · h
−1) or cimetidine (8 mg · kg
−1 · h
−1). The experiments were repeated after truncal vagotomy. The somatostatin responses to bombesin (0.5 μ · kg
−1 · h
−1) were also measured before and after vagotomy. Vagotomy decreased basal and postprandial somatostatin levels and reduced the somatostatin responses to feeding during the first 30-min period following the ingestion of the meal but not during subsequent periods. Bombesin-induced somatostatin release was increased after vagotomy. Atropine decreased the somatostatin responses to the meal before and after vagotomy. Cimetidine had no significant effect. These studies suggest that, in conscious dogs, somatostatin released into the circulation is partly under vagal control and that, as for gastrin release, vagal pathways for stimulation and inhibition are present. Our studies also suggest that cholinergic mechanisms are involved in the control of postprandial somatostatin release.</description><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bombesin</subject><subject>Bombesin - pharmacology</subject><subject>Cimetidine</subject><subject>Cimetidine - pharmacology</subject><subject>Dogs</subject><subject>Eating</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric Acid - metabolism</subject><subject>Gastric Mucosa - drug effects</subject><subject>Insulin - pharmacology</subject><subject>Reference Values</subject><subject>Somatostatin - blood</subject><subject>Somatostatin - metabolism</subject><subject>Vagal cholinergic</subject><subject>Vagotomy</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFLHDEUx4NU7Hb1G7SQg0g9jE0mM0nmUihiqyB4sScP4U3mRVJmJmOSFfz2Zt1ljz2EwHu__HnvF0K-cnbFGZc_ylEV47z9rvVlx5jWVX1EVlwrUXGp5SeyOiCfyZeU_jHGW6XECTmpddcJ0azI041zaDMNjr7Cc8hheqMwDxRyDIufkYaZLiOkCWgKE-SQMmQ_04hpCXNCmgMFOiGMtFRtKVkfNokO4TmdkmMHY8Kz_b0mf3_fPF7fVvcPf-6uf91XVmiZq9YKJlFw2TXQdo1qUNV13StnHQJnrUNlARmTg5Mga94DQC96lNB01nW1WJOLXe4Sw8sGUzaTTxbHEWYssxilBW_bsu-aNDvQxpBSRGeW6CeIb4Yzs3VqtsLMVpjR2nw4Ndv8b_v8TT_hcHi0l1j65_s-JAujizBbnw6YYqrjShbs5w7D4uLVYzTFFc4WBx_LF5gh-P_P8Q5GuZOP</recordid><startdate>19880501</startdate><enddate>19880501</enddate><creator>Woussen-Colle, Marie-Claire</creator><creator>Lalieu, Christine</creator><creator>Simoens, Christian</creator><creator>De Graef, Jacques</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880501</creationdate><title>Effect of vagotomy and atropine on plasma somatostatin response to a meal in conscious dogs</title><author>Woussen-Colle, Marie-Claire ; Lalieu, Christine ; Simoens, Christian ; De Graef, Jacques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-5c306e31694a59474e7222b7fcfea105fe7cae006df6a621baaab3be6a49cf923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bombesin</topic><topic>Bombesin - pharmacology</topic><topic>Cimetidine</topic><topic>Cimetidine - pharmacology</topic><topic>Dogs</topic><topic>Eating</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric Acid - metabolism</topic><topic>Gastric Mucosa - drug effects</topic><topic>Insulin - pharmacology</topic><topic>Reference Values</topic><topic>Somatostatin - blood</topic><topic>Somatostatin - metabolism</topic><topic>Vagal cholinergic</topic><topic>Vagotomy</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woussen-Colle, Marie-Claire</creatorcontrib><creatorcontrib>Lalieu, Christine</creatorcontrib><creatorcontrib>Simoens, Christian</creatorcontrib><creatorcontrib>De Graef, Jacques</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woussen-Colle, Marie-Claire</au><au>Lalieu, Christine</au><au>Simoens, Christian</au><au>De Graef, Jacques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vagotomy and atropine on plasma somatostatin response to a meal in conscious dogs</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1988-05-01</date><risdate>1988</risdate><volume>21</volume><issue>1</issue><spage>29</spage><epage>36</epage><pages>29-36</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>In 4 conscious dogs with gastric fistulas the somatostatin responses to a meal were measured and compared to the responses seen after i.v. infusion of atropine sulfate (20 and 50 μg · kg
−1 · h
−1) or cimetidine (8 mg · kg
−1 · h
−1). The experiments were repeated after truncal vagotomy. The somatostatin responses to bombesin (0.5 μ · kg
−1 · h
−1) were also measured before and after vagotomy. Vagotomy decreased basal and postprandial somatostatin levels and reduced the somatostatin responses to feeding during the first 30-min period following the ingestion of the meal but not during subsequent periods. Bombesin-induced somatostatin release was increased after vagotomy. Atropine decreased the somatostatin responses to the meal before and after vagotomy. Cimetidine had no significant effect. These studies suggest that, in conscious dogs, somatostatin released into the circulation is partly under vagal control and that, as for gastrin release, vagal pathways for stimulation and inhibition are present. Our studies also suggest that cholinergic mechanisms are involved in the control of postprandial somatostatin release.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2899334</pmid><doi>10.1016/0167-0115(88)90088-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Atropine - pharmacology Biological and medical sciences Bombesin Bombesin - pharmacology Cimetidine Cimetidine - pharmacology Dogs Eating Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastric Acid - metabolism Gastric Mucosa - drug effects Insulin - pharmacology Reference Values Somatostatin - blood Somatostatin - metabolism Vagal cholinergic Vagotomy Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effect of vagotomy and atropine on plasma somatostatin response to a meal in conscious dogs |
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